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Table 3 Proof-of-concept searches showing the number of relevant articles retrieved with and without glomerular disease filter

From: Glomerular disease search filters for Pubmed, Ovid Medline, and Embase: a development and validation study

Clinical Question* Physician search alone Physician search with the high-sensitivity filter Physician search with the high-specificity filter
  Number of non-relevant articles retrieved Number of relevant articles retrieved Number of non-relevant articles retrieved Number of relevant articles retrieved Number of non-relevant articles retrieved Number of elevant articles retrieved
What are the efficacy and safety of mycophenolate mofetil (MMF) and cyclophosphamide (CYC) in the treatment of proliferative lupus glomerulonephritis (GN)? (7 relevant articles) [29] 2006 7 1721 7 1080 7
Is immunosuppressive treatment effective and safe in the treatment of idiopathic membranous nephropathy (IMN) in adults with nephrotic syndrome? (15 relevant articles) [30] 87500 15 3231 15 2687 15
Does corticosteroid therapy ameliorate the acute manifestations of Henoch-Schonlein purpura or mitigate renal injury? (15 relevant articles) [31] 393 5 68 5 65 5
What are the benefits and harms of different interventions for the treatment of renal vasculitis in adults? (13 relevant articles) [32] 34741 8 8455 8 5923 8
What is the effect of a low-protein diet (LPD) on renal function in patients with type 1 or 2 diabetic renal diseases? (8 relevant articles) [33] 868 7 207 7 180 6
What are the benefits and harms of interventions for the nephrotic syndrome in adults caused by minimal change disease? (3 relevant articles) [28] 4662 3 1236 3 1203 3
  1. * The search phrases as determined and typed in by physicians were: ‘(mycophenolate OR cyclophosphamide) lupus’, ‘treatment membranous’, ‘steroid HSP’, ‘renal vasculitis treatment limit to english, core journals, adults’, ‘low protein diet diabetes’, and ‘minimal change treatment’.