Figure 1

Illustration of the net benefit for the treated, for the untreated and overall. Decision curves based on the net benefit for the treated (a), the net benefit for the untreated (b) and the overall net benefit (c) for a simple example model and a complex example model, accompanied by the reference strategies of treating none or treating all and a hypothetical perfect prediction model ("omniscient"). Note that the addition of the decision curves for the treated (a) and the untreated (b) results in the decision curves in (c).