|
calendar year
|
before 2004 vs. 2007 and after
|
2.06
|
(1.67-2.54)
|
< 0.0001
|
| |
2004 vs. after 2007 and after
|
1.62
|
(1.29-2.03)
|
< 0.0001
|
| |
2005-2006 vs. 2007 and after
|
1.28
|
(1.06-1.55)
|
0.0109
|
|
cART
|
2NRTI+1PI vs. 2NRTI+1NNRTI
|
1.03
|
(0.83-1.27)
|
0.8028
|
| |
2NRTI+1PI/r vs. 2NRTI+1NNRTI
|
0.63
|
(0.54-0.75)
|
< 0.0001
|
| |
3NRTI vs. 2NRTI+1NNRTI
|
1.23
|
(0.92-1.64)
|
0.1599
|
|
age (per 10 years older)
|
0.89
|
(0.82-0.96)
|
0.0036
|
|
gender (male vs. female)
|
1.06
|
(0.91-1.23)
|
0.4668
|
|
mode of HIV-1 transmission
|
male homosexual vs. heterosexual
|
1.08
|
(0.88-1.33)
|
0.4680
|
| |
IDU vs. heterosexual
|
1.08
|
(0.87-1.32)
|
0.4898
|
| |
other/unknown vs. heterosexual
|
1.08
|
(0.9-1.29)
|
0.4248
|
|
nationality
|
non-Italian vs. Italian
|
1.23
|
(0.9-1.67)
|
0.1992
|
| |
unknown vs. Italian
|
0.94
|
(0.78-1.14)
|
0.5475
|
|
HCV/HBV coinfection
|
unknown vs. no
|
1.18
|
(0.97-1.45)
|
0.1049
|
| |
yes vs. no
|
1.04
|
(0.82-1.32)
|
0.7277
|
|
HIV-1 RNA per log10 copies/ml higher
|
1.27
|
(1.17-1.39)
|
< 0.0001
|
|
CD4+ count cells/mm3
|
< = 100 vs. > 500
|
1.57
|
(1.23-2)
|
0.0003
|
| |
> 100 and < = 199 vs. > 500
|
1.16
|
(0.93-1.45)
|
0.1968
|
| |
> 200 and < = 349 vs. > 500
|
1.22
|
(1-1.48)
|
0.0447
|
| |
> 350 and < = 499 vs. > 500
|
0.98
|
(0.79-1.21)
|
0.8202
|
|
interval time from the first HIV-1 positive test to ART initiation
|
< = 12 vs. > 60 months
|
0.87
|
(0.67-1.13)
|
0.2944
|
| |
> 12 and < = 60 vs. > 60 months
|
1.01
|
(0.81-1.27)
|
0.9114
|
| |
unknown vs. > 60 months
|
0.92
|
(0.77-1.11)
|
0.3938
|
|
duration of prior ART exposures
|
< = 6 vs. > 24 months
|
0.84
|
(0.7-1.01)
|
0.0626
|
| |
> 6 and < = 12 vs. > 24 months
|
0.92
|
(0.73-1.17)
|
0.5029
|
| |
> 12 and < = 24 vs. > 24 months
|
0.83
|
(0.66-1.03)
|
0.0890
|
|
previous AIDS-defining events (yes vs. no)
|
0.86
|
(0.7-1.05)
|
0.1379
|
|
#previous ART switches
|
1.03
|
(1-1.05)
|
0.0522
|
|
previous ART class exposure
|
NRTI vs. ART-naïve
|
1.48
|
(1.01-2.17)
|
0.0441
|
| |
NRTI and NNRTI vs. ART-naïve
|
1.38
|
(0.99-1.93)
|
0.0546
|
| |
NRTI and NNRTI and PI vs. ART-naïve
|
1.43
|
(1.03-1.99)
|
0.0315
|
| |
NRTI and NNRTI and PI/r vs. ART-naïve
|
2.96
|
(2.16-4.06)
|
< 0.0001
|
| |
NRTI and PI vs. ART-naïve
|
2.18
|
(1.64-2.89)
|
< 0.0001
|
| |
NRTI and PI/r vs. ART-naïve
|
2.72
|
(1.98-3.75)
|
< 0.0001
|
| |
other classes vs. ART-naïve
|
2.31
|
(1.31-4.05)
|
0.0036
|
|
previous exposure to suboptimal ART (yes vs. no)
|
0.85
|
(0.71-1.03)
|
0.0946
|
|
viral subtype
|
02_AG vs. B
|
0.98
|
(0.61-1.57)
|
0.9402
|
| |
C vs. B
|
1.41
|
(0.86-2.32)
|
0.1748
|
| |
F1 vs. B
|
0.57
|
(0.3-1.06)
|
0.0750
|
| |
other vs. B
|
1.26
|
(0.76-2.09)
|
0.3774
|
| |
undetermined vs. B
|
1.12
|
(0.88-1.42)
|
0.3527
|
|
GSS*
|
ANRS per 1 point increase
|
0.72
|
(0.66-0.78)
|
< 0.0001
|
| |
HIVdb per 1 point increase
|
0.68
|
(0.63-0.74)
|
< 0.0001
|
| |
Rega per 1 point increase
|
0.71
|
(0.66-0.77)
|
< 0.0001
|
