Derivation parameters | Details |
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1. Clinically evident cardiovascular-renal complications | History of stroke, coronary heart disease, non-fatal heart failure, peripheral vascular disease, end stage renal disease (dialysis or eGFR <15 ml/min/1.73 m2) |
2. Risk stratification parameters | Current or ex smoker BMI ≥ 27.5 kg/m2 or waist circumference ≥ 80 cm in women or ≥ 90 cm in men Blood pressure >130/80 mmHg or treatment with anti-hypertensive drugs LDL-C >2.5 mmol/l TG ≥ 2.3 mmol/l &/or HDL-C <1 mmol/l Treatment with lipid regulating drugs if LDL-C ≤ 2.5 mmol/l and TG <2.3 mmol/l and HDL-C ≥ 1.0 mmol/l Spot morning urine for ACR >3.5 mg/mmol in women or >2.5 mg/mmol in men Foot at risk defined by 2 of 3 of the following: sensory neuropathy, skin changes (e.g. fungal infection, dry skin) or deformities (e.g. claw feet or hallux deformities) Retinopathy HbA1c ≥ 8% |
3. Hong Kong Diabetes Registry Risk Scores | High sensitivity and specificity cutoff points for various clinical endpoints (stroke, coronary heart disease, end stage renal disease and heart failure) |
4. Renal function | eGFR by the MDRD equation |