Open Access
Open Peer Review

This article has Open Peer Review reports available.

How does Open Peer Review work?

A method for managing re-identification risk from small geographic areas in Canada

  • Khaled El Emam1, 2Email author,
  • Ann Brown1,
  • Philip AbdelMalik3,
  • Angelica Neisa1,
  • Mark Walker4,
  • Jim Bottomley5 and
  • Tyson Roffey5
BMC Medical Informatics and Decision Making201010:18

DOI: 10.1186/1472-6947-10-18

Received: 28 May 2009

Accepted: 2 April 2010

Published: 2 April 2010

Abstract

Background

A common disclosure control practice for health datasets is to identify small geographic areas and either suppress records from these small areas or aggregate them into larger ones. A recent study provided a method for deciding when an area is too small based on the uniqueness criterion. The uniqueness criterion stipulates that an the area is no longer too small when the proportion of unique individuals on the relevant variables (the quasi-identifiers) approaches zero. However, using a uniqueness value of zero is quite a stringent threshold, and is only suitable when the risks from data disclosure are quite high. Other uniqueness thresholds that have been proposed for health data are 5% and 20%.

Methods

We estimated uniqueness for urban Forward Sortation Areas (FSAs) by using the 2001 long form Canadian census data representing 20% of the population. We then constructed two logistic regression models to predict when the uniqueness is greater than the 5% and 20% thresholds, and validated their predictive accuracy using 10-fold cross-validation. Predictor variables included the population size of the FSA and the maximum number of possible values on the quasi-identifiers (the number of equivalence classes).

Results

All model parameters were significant and the models had very high prediction accuracy, with specificity above 0.9, and sensitivity at 0.87 and 0.74 for the 5% and 20% threshold models respectively. The application of the models was illustrated with an analysis of the Ontario newborn registry and an emergency department dataset. At the higher thresholds considerably fewer records compared to the 0% threshold would be considered to be in small areas and therefore undergo disclosure control actions. We have also included concrete guidance for data custodians in deciding which one of the three uniqueness thresholds to use (0%, 5%, 20%), depending on the mitigating controls that the data recipients have in place, the potential invasion of privacy if the data is disclosed, and the motives and capacity of the data recipient to re-identify the data.

Conclusion

The models we developed can be used to manage the re-identification risk from small geographic areas. Being able to choose among three possible thresholds, a data custodian can adjust the definition of "small geographic area" to the nature of the data and recipient.

Background

The disclosure and use of health data for secondary purposes, such as research, public health, marketing, and quality improvement, is increasing [16]. In many instances it is impossible or impractical to obtain the consent of the patients ex post facto for such purposes. But if the data are de-identified then there is no legislative requirement to obtain consent.

The inclusion of geographic information in health datasets is critical for many analyses [715]. However, the inclusion of geographic details in a dataset also makes it much easier to re-identify patients [1618]. This is exemplified by a recent Canadian federal court decision which noted that the inclusion of an individual's province of residence in an adverse drug event dataset makes it possible to re-identify individuals [19, 20].

Records from individuals living in small geographic areas tend to have a higher probability of being re-identified [2123]. Some general heuristics for deciding when a geographic area is too small with respect to identifiability have been applied by national statistical agencies [2429]. For example, the US Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule defines a small geographic area as one having a population smaller than 20,000.

Common disclosure control actions for managing the re-identification risks from small geographic areas are to: (a) suppress records in the small geographic areas, (b) remove from the disclosed dataset some of the non-geographic variables, (c) reduce the number of response categories in the non-geographic variables (i.e., reduce their precision), or (d) aggregate the small geographic areas into larger ones. None of these options is completely satisfactory in practice. Options (a) and (b) result in the suppression of records or variables respectively. The former leads to the loss of data and hence reduces the statistical power of any analysis, and can also result in bias if the suppressed records are different in some important characteristics from the rest of the data. The latter is often difficult to implement because variables critical to the analysis of the data cannot be removed. Options (c) and (d) reduce the precision of the information in the dataset through generalization. The former generalizes the non-geographic information in the dataset which may make it difficult to detect subtle trends and relationships. The latter can reduce the ability to perform meaningful analysis and can conceal variations that would otherwise be visible at smaller geographical scales [3035].

Given the detrimental effects of such disclosure control actions, it is important to have accurate and proportionate methods for assessing when a geographic area is too small.

The uniqueness of individuals is often used as a surrogate measure of re-identification risk [36]. An individual is unique if s/he is the only individual with a specific combination of values on their personal characteristics that are included in a dataset. There is a monotonically decreasing relationship between uniqueness and geographic area population size: uniqueness decreases as population size gets larger. A recent study developed a model to decide when a geographic area is too small based on the uniqueness of its population [37]: if uniqueness within a geographic area is approximately zero then the geographic area is not too small.

However, using zero uniqueness as a threshold for disclosure control is quite stringent and can result in excessive record or variable suppression and/or aggregation. Higher uniqueness thresholds have been found acceptable and have been applied in practice. Specifically, previous disclosures of cancer registry data have deemed thresholds of 5% and 20% population uniqueness as acceptable for public release and research use respectively [3840].

In this paper we extend this line of work by developing models to determine whether a Forward Sortation Area (FSA - the first three characters of the Canadian postal code) is too small based on the 5% and 20% uniqueness thresholds by analyzing Canadian census data. We also provide data release risk assessment guidelines for deciding which one among the 0%, 5%, and 20% threshold models to use for disclosure control.

Methods

Our approach was to construct models to determine if the percentage of unique records in a particular FSA was above the 5% and the 20% thresholds. These models characterize each FSA in terms of its population size, and also take into account the characteristics of the non-geographic variables in the dataset that can be used for re-identification.

Definitions

Quasi-identifiers

The variables in a dataset that can be used to re-identify individuals are called the quasi-identifiers[41]. Examples of common quasi-identifiers are [37, 4244]: dates (such as, birth, death, admission, discharge, visit, and specimen collection), race, ethnicity, languages spoken, aboriginal status, and gender.

Equivalence Class

An equivalence class is defined as the group of records having a given set of values on the quasi-identifiers. For example, "50 year old male" represents the equivalence class of records with the "50" value on the age quasi-identifier and "Male" on the gender quasi-identifier. The number of records that have these two values on the quasi-identifiers is the size of the "50 year old male" equivalence class.

Uniqueness

The uniqueness of records in the dataset is based only on the quasi-identifiers. For example, if our quasi-identifiers are age and gender, then say, the only 90 year old female in the FSA "N3E" would be a unique record on these quasi-identifiers within that geographic area. Other sensitive variables that are not considered quasi-identifiers are not taken into account in the computation of uniqueness. If an equivalence class is of size one, then that represents a unique record.

Focus on the Forward Sortation Area (FSA)

The postal code is the basic geographical unit that we will use in our analysis. The postal code is frequently collected because it is readily available, and consequently, it is used as the geographical location of residence in health datasets [4550]. The full six character postal code is often more specific than needed for many analyses. Further, in combination with other variables the full postal code would make it easy to re-identify individuals, especially in residential urban areas [43]. While there are many potential ways of aggregating geographic regions to construct larger areas for analysis [35], the FSA, a higher level in the postal code geographic hierarchy, is the unit that we considered.

Dataset

The dataset we used comes from the 2001 Canadian census. The census has two forms: the short form and the long form. Approximately a 20% sample of the population completes the long form, and the remainder completes the short form. The long form individual level data is made available to researchers by Statistics Canada through its Research Data Centers (RDCs).

The RDC long form dataset only has geographic information at the level of the census tract. Because our desired analysis is at the FSA geographic unit, we developed a gridding methodology, described in Additional file 1, to assign the FSAs to individual records based on their census tracts. Census tracts are only defined for urban areas and do not cover Prince Edward Island (PEI). Therefore, rural FSAs and PEI were excluded from our analysis.

Table 1 contains the list of quasi-identifiers that were analyzed from the long form census file. These were selected to be representative of commonly used quasi-identifiers in health and health systems research. The table also includes the number of response categories for each quasi-identifier as they were used in our analysis.
Table 1

The list of quasi-identifiers that were analyzed from the census file

Variable Name in the 2001 Census RDC File

Definition

# Response categories(*)

SEXP

Gender

2

BRTHYR

Year of birth (from 1880 to 2001).

Age: We defined age categories based on 5 year ranges.

24

HLNABDR

Language: Language spoken most often at home by the individual at the time of the census.

4

ETH1-6

Ethnic Origin: Refers to the six possible answers for the ethnic or cultural group(s) to which the respondent's ancestors belong.

26

ASRR

Aboriginal Identity: Persons identifying with at least one Aboriginal group.

8

RELIGWI

Religious denomination: Specific religious denominations, groups or bodies as well as sects, cults, or other religiously defined communities or systems of belief.

3

TOTYRSR

Total Years of Schooling: Total sum of the years (or grades) of schooling at the elementary, high school, university and college levels. Only available for individuals age 15+.

9

MARST

Marital Status (Legal)

5

TOTINC

Total income: Total money income received from all sources during the calendar year 2000 by persons 15 years of age and over. We defined categories in $15K ranges.

22

DVISMIN

Visible minority status

4

DISABIL

Activity difficulties/reductions: Combinations of one or more activity difficulties/reduction.

4

(*) The number of response categories excludes non-specific responses such as missing values, not available or "other".

Quasi-identifier Models

A quasi-identifier model consists of two or more quasi-identifiers (qid). To manage the scope of the analysis we consider only combinations of up to and including 5 qids. A total of 358 quasi-identifier models were analyzed. This results from the following approach of combining the qids.

Initially, for the 11 qids listed in Table 1, there are some similarities related to ethnicity and therefore they were treated as a group: HLNABDR, ETH1-6, RELIGWI, and DVISMIN. We defined a generic ethnicity variable, and whenever that generic ethnicity variable appears in a model it was replaced by one of the above four variables. Each substitution represented a different model. Thus, this gives 8 distinct qids: gender, age, ethnicity (generic), schooling, marital status, total income, aboriginal identity and activity difficulties.

Categorizing the 8 distinct qids by their utility by an intruder for re-identification gives the following two types:

  • High utility to an intruder: gender, and age

  • Possibly used for re-identification/sensitive: ethnicity, schooling, marital status, total income, aboriginal identity and activity difficulties

The different models were defined by the number of qids in the model and by having at least one sensitive qid included in each model.

For models including both age and gender, there are 42 models for the 8 distinct qids as follows:

  • 5 qids: have age and gender and 20 combinations of 3 of the 6 sensitive qids.

  • 4 qids: have age and gender and 15 combinations of 2 of the 6 sensitive qids.

  • 3 qids: have age and gender and each of the 6 sensitive qids.

  • 2 qids: have age and gender only - there is only one model.

Then substituting each of language, religion and visible minority for ethnicity gives an additional 48 models: 30 (3 × 10) models for 5 qids (ethnicity appears in 10 of the 20 models), 15 (3 × 5) models for 4 qids (ethnicity appears in 5 of the 15 models), and 3 (3 × 1) models for 3 qids (ethnicity appears in one of the 6 models).

The subtotal for this group of models containing both age and gender is 90 (42+48).

We repeated the above process for each one of age and gender in combination with the sensitive qids. That is there are 56 models containing:

  • 5 qids: have age and 15 combinations of 4 of the 6 sensitive qids.

  • 4 qids: have age and 20 combinations of 3 of the 6 sensitive qids.

  • 3 qids: have age and 15 combinations of 2 of the 6 sensitive qids.

  • 2 qids: have age and each of the 6 sensitive qids only.

Similarly to the previous group, by taking into account the ethnicity related variables, there are a sub-total of 134 models for this group.

Lastly, age is replaced with gender for an additional 134 models. Adding up the sub-totals gives a total number of 358 quasi-identifier models.

For each quasi-identifier model, we denote its maximum number of equivalence classes as its MaxCombs value. The MaxCombs value for any quasi-identifier model can be computed from Table 1. For example, if we consider the four quasi-identifiers: Age, Marital Status, Schooling, Religion, then there are 24 (age) × 5 (marital status) × 9 (years of schooling) × 3 (religion) = 3,240 possible values on these variables, which is the MaxCombs value. The MaxCombs values range from 6 to 718,848 across all quasi-identifier models.

Estimating Uniqueness

There are a number of different approaches that can be used to estimate uniqueness in the population from the 20% sample.

The first study to examine uniqueness in the general population was conducted in the US by Sweeney [51]. Relying on the generalized Dirichlet drawer principle, she made inferences about uniqueness in specific geographic areas. This principle states that if N objects are distributed in k boxes, then there is at least one box containing at least https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_IEq1_HTML.gif objects (i.e., the largest integer within the brackets). If Nk then there is at least one box with a single object (i.e., a unique).

Sweeney made the conservative assumption that if there is any unique in a particular geographic area, say an FSA, then that FSA is high risk. She then reported the percentage of individuals in high risk geographic areas. For example, if we consider a quasi-identifier model with a MaxCombs value of 48 (the k value), then any FSA with a population smaller than 48, say 15 (the N value), would likely have a unique individual in it, and therefore all 15 individuals would be considered at a high risk of uniqueness.

However, this approach will tend to overestimate the percentage of uniques because not all individuals in the FSA will be unique. For example, in the case above, on average, 26% of the 15 individuals would be non-unique. Furthermore, the Sweeney method does not help us with estimating if uniqueness is above 5% or 20% for a particular FSA.

An earlier study, which predicted when a geographic area is too small, was based on the zero uniqueness threshold utilizing a public use census file [37]. That study assumed that as sample uniqueness approached zero, the population uniqueness also approached zero. This assumption is not suitable for directly estimating population uniqueness at a 5% or 20% threshold.

Another approach to estimate equivalence class sizes was taken by Golle [52], where he assumed a uniform distribution of dates of birth of individuals living in a geographic area in assigning them to equivalence classes. However, that approach was driven by the author only having access to high level census tabulations, and was limited to a single variable. In our case the uniform distribution assumption cannot be justifiably extended to all of the quasi-identifiers.

For our analysis we used the individual-level Canadian census dataset. Given that the long form census dataset is a 20% sample of the Canadian population, we utilized uniqueness estimators to determine the proportion of unique records for each combination of FSA and quasi-identifier model. The reason we need to estimate population uniqueness is because sample uniqueness does not necessarily equate to population uniqueness, and we are interested in population uniqueness.

One estimator developed by Bethlehem et al. [36, 53] over-estimates with small sampling fractions and under-estimates as the sampling fraction increases [54]. We therefore adopted a different estimation approach developed by Zayatz [31, 55]. While this approach tends to over-estimate the number of population uniques for small sampling fractions, our 20% sampling fraction would be large enough to alleviate concerns about bias [54].

Prediction Models

Based on the uniqueness estimate for each quasi-identifier model and FSA, two binary variables were constructed: the first is 1 if the estimated uniqueness for a particular FSA and quasi-identifier model was above 5% and zero otherwise, and the second was 1 if the estimated uniqueness was above 20% and zero otherwise.

This is illustrated in Table 2 through a series of examples. Here we have seven example FSAs, and for each one a set of quasi-identifiers (quasi-identifier model) is shown. For example, for the "K7N" we have the "age × sex" quasi-identifier model. For each FSA and quasi-identifier model combination we show the uniqueness estimate. Recall that we only have data on 20% of the population, therefore the uniqueness estimate gives us the percentage of individuals in that FSA who are unique on their quasi-identifier values. For instance, in "L6P" 16.7% of the population are unique on their gender, aboriginal status, schooling, and language spoken at home. The last two columns of the table indicate whether the estimated uniqueness is greater than 5% and greater than 20% respectively. Such a table was constructed for all FSAs and for all quasi-identifier models. This table had 342,606 rows.
Table 2

Example uniqueness estimates, POP and MaxCombs values for some FSA and quasi-identifier combinations.

Example of Uniqueness Estimates for FSA and Quasi-identifier Model Combinations

ID

FSA

Quasi- Identifiers

Uniqueness ( https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_IEq2_HTML.gif )

https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_IEq2_HTML.gif >5%

https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_IEq2_HTML.gif >20%

1

K7N

Age, Sex

0%

N

N

2

M2K

Age, Aboriginal, Religion

1.7%

N

N

3

K1A

Sex, Marital Status, Language

14.3%

Y

N

4

L6P

Sex, Aboriginal, Schooling, Language

16.7%

Y

N

5

H3T

Age, Aboriginal, Income, Marital Status, Language

56.0%

Y

Y

6

L1 M

Sex, Disability, Marital Status, Schooling, Ethnicity

67.80%

Y

Y

7

K1A

Age, Disability, Income, Marital Status, Schooling

94.70%

Y

Y

We developed one binary logistic regression model [56] with the 5% binary variable (denoted by I 05) as the response variable, and another with the 20% binary variable (denoted by I 20) as the response variable. The predictor variables in this model characterize the FSA and the quasi-identifiers in the quasi-identifier model.

An FSA can be characterized by its population size, which was obtained from the census data. We denote this variable by POP. For example, the "K7N" FSA in Table 3 has a POP value of 6,228, and the "L6P" FSA has a POP value of 2,247. The POP variable ranged from 200 to 78,457.
Table 3

Example of what the raw data used to build the models looked like.

Example of Raw Data Used in Building the Logistic Regression Models

ID

POP

MaxCombs

I 05

I 20

1

6,228

48

0

0

2

14,047

576

0

0

3

100

40

1

0

4

2,247

576

1

0

5

12,916

84,480

1

1

6

7,080

9,360

1

1

7

100

95,040

1

1

(b) The population uniqueness binary value is used in the logistic regression model with the other predictor variables. We used the 2001 Canadian Census population values.

In a previous study it was shown that MaxCombs was a good predictor of uniqueness [37]. We therefore use it to characterize the quasi-identifier model used. Table 3 includes the MaxCombs values for each of the quasi-identifier models in our example, as well as the response variables for the logistic regression models. The data in Table 3 are an example of the raw values that we used in building the regression models. An observation is an FSA by quasi-identifier model combination (as shown in Table 3). For example, there is one observation for the "K7N" FSA for the quasi-identifier model "age × sex".

The 5% model was defined as:
https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Equa_HTML.gif

where π 05 is the probability that an observation is high risk (uniqueness greater than 5%) and the b parameters were estimated. The logistic regression models were estimated and evaluated using SAS version 9.1. We included an interaction term in the model so that we can adjust the relationship between MaxCombs and uniqueness according to the population size of the FSA (instead of creating a separate model for each FSA). The 20% model was similarly constructed.

To avoid collinearity with the interaction term in the model, both predictor variables were centered [57]. Collinearity occurs when there are linear dependencies among the predictor variables, and between predictor variables and the intercept [58]. Because both POP and MaxCombs have large values, the interaction term in the logistic regression model can create overflow problems during computation. We therefore scaled the predictor variables by 10,000.

Influential observations were identified and removed [59]. As noted below, models on different subsets of the data were constructed during our evaluation. The percentage of influential observations varied from less than 0.5% to 2.2% across these models.

Unbalanced Dataset

Our dataset was unbalanced. This means that the proportion of observations with uniqueness less than 20% was quite small, and similarly for the proportion of observations with uniqueness less than 5%. Constructing regression models with an unbalanced dataset can result in poor model fit, inaccuracy in predicting the less prevalent class, and may even impede the convergence of the numeric maximum likelihood estimation algorithms.

There are three approaches for dealing with an unbalanced dataset: (a) a down-sampling or prior correction approach reduces the number of observations so that the two classes in the logistic regression model are equal, (b) the use of weights, and (c) an alternative correction which uses the full dataset and shown to be an improvement over weighting by King and Zeng (KZ) [60]. It has been noted that the weighting approach suffers a loss in efficiency compared to an unweighted approach when the model is exact [61], and the KZ method is shown to be better than using weights [60]. We therefore built models using two approaches and compared their results: (a) re-balancing using down-sampling, and adjusting the parameter estimates accordingly [60, 62, 63], and (b) the KZ method [60].

Method for Model Evaluation

We compared both methods for dealing with the unbalanced dataset problem on three values: the area under the curve (AUC) of the Receiver Operating Characteristic curve [64, 65], sensitivity, and specificity. The latter two metrics are defined more precisely in Figure 1 (the AUC is based on the definitions of specificity and sensitivity).
https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Fig1_HTML.jpg
Figure 1

Definition of prediction evaluation metrics. Low Risk means that the (predicted) percentage of unique records is below or equal to the 5% or 20% threshold. High Rish means that the (predicted) percentage of unique records is above the 5% or 20% threshold.

The AUC has an intuitive interpretation: it is the estimated probability that a randomly selected observation that is above the uniqueness threshold will have a higher predicted probability from the logistic regression model than a randomly selected observation that is below the uniqueness threshold [66, 67]. Sensitivity is defined as the proportion of actually high risk records (above the threshold) which were correctly predicted as such. Specificity is defined as the proportion of actually low risk records (below or equal to the threshold) which were correctly predicted as such. For computing the above metrics, if the predicted probability on the 5% threshold model was greater than 0.5 then the FSA was deemed to have a uniqueness greater than 5%. A similar predicted probability cut-off was used for the 20% threshold model.

We used 10-fold cross-validation to generate the training and test datasets, which is a generally accepted practice to evaluate prediction models in the machine learning literature [68, 69]. That is, we divided the dataset used to build the logistic regression model into deciles and used one decile in turn as the test dataset, and the remaining nine deciles to build (train) the model. In the context of ten-fold cross-validation, the down-sampling and KZ methods were performed separately on the nine training deciles each time a model was estimated. All the predictions across the 10-folds were then tabulated in a 2 × 2 confusion matrix and the prediction accuracy was evaluated as illustrated in Figure 1. A confusion matrix shows the cross-tabulation of the number of observations predicted to be above/below the threshold vs. the number of observations that were actually above/below the threshold.

Results

Description of Canadian FSAs

Our models pertain to urban FSAs. We therefore provide a descriptive comparison of urban vs. rural FSAs in Canada.

The population distribution for FSAs in the nine Canadian provinces is shown in Figure 2, and overall in Figure 3. Except for New Brunswick, rural FSAs tend to have more people living in them. The majority of the population lives in urban FSAs, except for Newfoundland, and to a lesser extent Saskatchewan, where the population is more evenly split between rural and urban FSAs. Table 4 shows the distribution of FSAs based on whether they are rural or urban. Even though they have smaller populations, the majority of FSAs are urban rather than rural. Figure 4 shows that in terms of physical size rural FSAs tend to have a considerably larger area than urban ones.
Table 4

Distribution of FSAs based on whether they are urban or rural.

Prov

Total Rural

Total Urban

Grand Total

%Rural

%Urban

AB

12

138

150

8.00%

92.00%

BC

18

171

189

9.52%

90.48%

MB

10

54

64

15.63%

84.38%

NB

 

110

110

0.00%

100.00%

NL

13

22

35

37.14%

62.86%

NS

14

62

76

18.42%

81.58%

ON

56

466

522

10.73%

89.27%

QC

39

374

413

9.44%

90.56%

SK

11

37

48

22.92%

77.08%

Grand Total

173

1434

1607

10.77%

89.23%

https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Fig2_HTML.jpg
Figure 2

The population sizes for urban and rural FSAs in Canadian provinces.

https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Fig3_HTML.jpg
Figure 3

The population sizes for urban and rural FSAs in Canada overall.

https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Fig4_HTML.jpg
Figure 4

Areas in km 2 for urban and rural FSAs in Canadian provinces.

Model Comparison

The two approaches for building the logistic regression models are compared in Table 5 for the two uniqueness thresholds. These results were obtained using 10-fold cross-validation. In terms of the AUC, the differences are very small and for practical purposes their predictive accuracies can be considered equivalent. The table also shows the sensitivity and specificity results using a predicted probability threshold of 0.5, which is consistent with the way that the models would be used in practice. Here we see that both modeling approaches had very similar specificity, but down-sampling had higher sensitivity for both uniqueness thresholds. Therefore, we will use the down-sampling model results in the rest of this paper.
Table 5

Comparison of unbalanced data modeling methods.

Model Evaluation for the 5% Uniqueness Threshold

 

AUC

Sensitivity

Specificity

Down-Sampling

0.9849

0.87

0.996

KZ

0.9849

0.449

0.992

Model Evaluation for the 20% Uniqueness Threshold

 

AUC**

Sensitivity

Specificity

Down-Sampling

0.947

0.74

0.98

KZ

0.949

0.59

0.949

**We tested the difference between the AUC values, and the difference was statistically significant between the two methods only for 20% uniqueness at an alpha level of 0.05

Model Results

Both models had a significant goodness of fit (p < 0.001) [56]. The model parameters are shown in Table 6. All model parameters are significant, including the interaction term.
Table 6

Logistic regression model results for the 5% and 20% thresholds using down-sampling.

Logistic Regression Model for 5% Threshold

 

Intercept

POP

MaxCombs

POP × MaxCombs

Coefficient

779.1

-37.35

137.8

-6.5

95% CI

(744, 815.5)

(-60.46, -13.72)

(131.6, 144.2)

(-10.61, -2.36)

p-value

<0.0001

<0.0017

<0.001

0.0019

Logistic Regression Model for 20% Threshold

 

Intercept

POP

MaxCombs

POP × MaxCombs

Coefficient

63.3

-6

11.8

-1

95% CI

(61.85, 64.74)

(-6.83, -5.16)

(11.59, 12.1)

(-1.16, -0.86)

p-value

<0.0001

<0.0001

<0.0001

<0.0001

Discussion

Using the Models

In this paper we developed models to predict whether the population in a geographic area has uniqueness above the 5% and 20% thresholds using data from the Canadian census. We also demonstrated that the prediction models are sufficiently accurate to meet the risk and utility needs of data custodians and data recipients respectively. The areal unit that we studied was the urban FSA.

The logistic regression models can be used to determine whether or not the FSAs in actual datasets are too small. The MaxCombs value is computed based on the quasi-identifiers in the dataset. For each FSA, its population value can be determined from the Statistics Canada population tables. With these two values we can predict the probability that the percentage of uniques is above the 5% or 20% uniqueness thresholds. If the predicted probability is above 0.5, then disclosure control actions are necessary. For example, records in that FSA must be suppressed or combined with another FSA in the dataset. Alternatively, some variables may need to be removed or generalized to reduce the MaxCombs value.

Because the predictor variables in the models were centred and scaled, this also has to be done when using the models for actual prediction. Let the MaxCombs value for a particular dataset be denoted by M. We index the FSAs in a dataset by j. Let the population size for a particular FSA in the dataset be denoted by S j .

We have the centered and scaled MaxCombs value:
https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Equ1_HTML.gif
(1)
and the centered and scaled population size value:
https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Equ2_HTML.gif
(2)
Then an FSA is considered to be high risk under the 5% threshold if the following condition is true:
https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Equ3_HTML.gif
(3)
and an FSA is considered to be high risk under the 20% threshold if the following condition is true:
https://static-content.springer.com/image/art%3A10.1186%2F1472-6947-10-18/MediaObjects/12911_2009_Article_319_Equ4_HTML.gif
(4)

For the FSAs that are flagged through equations (3) or (4) then one should apply disclosure control actions.

Generalization of Models

There are two types of generalizations for these models: generalization to other quasi-identifiers and generalizations to other urban areal units apart from the FSA.

Our results indicate that MaxCombs is a very good predictor of uniqueness. The value of MaxCombs does not care what type of quasi-identifiers we have - it is only affected by the number of response categories in the quasi-identifiers. A previous study has shown that taking into account the distribution of the quasi-identifiers using an entropy metric did not result in any improvement in the prediction of uniqueness [37]. One explanation for this is that we have a ceiling effect: the prediction accuracy is quite high already that the addition of distribution information cannot make a significant improvement. Consequently, a strong case can be made that the models can be used with other demographic quasi-identifiers even if they are not explicitly represented in the census dataset, and if the MaxCombs is within the range used in our study.

Another question is whether there is a basis for generalizing the results to other urban areal units, for example, full postal codes (which are subsets of FSAs) or regions (which are aggregates of FSAs) ? Given that the prediction models are quite accurate using only the population size as a characteristic of the area, then there is no a priori reason not to be able to apply the models to other areas as long as their population sizes are within the range used for our models and that they are for urban Canadian areas.

Application of Models

We applied the models to evaluate whether the FSA sizes were appropriate on two data sets: the newborn registry of Ontario (Niday) and emergency department data from the children's hospital in Ottawa. In this application we assume that the disclosure control action taken is the suppression of records in small FSAs.

The Niday registry captures information about all births in the province. We used a data extract for all births during 2005-2007 fiscal years. There were 164,272 usable records in the registry during that period. The quasi-identifiers that were considered were: mother's age, baby's month and year of birth, baby's gender, and the primary language spoken at home.

The proportion of records in the Niday registry that would have to be suppressed under each of the three thresholds was computed. The results of this analysis are shown in Table 7. For example, under the 0% uniqueness threshold, 85% of the dataset would be in FSAs that are deemed too small. These small FSAs would have to be suppressed. As can be seen, there is a pronounced difference between using the 0% threshold and the others, with far less data having to be suppressed for the 5% and 20% thresholds. These results demonstrate that, where the risk profile is acceptably low, using a higher threshold can result in significantly more data being made available.
Table 7

The percentage of Niday and emergency department records that would have to be suppressed because they are high risk for each of the uniqueness thresholds.

 

0% Threshold

5% Threshold

20% Threshold

Niday

85%

77%

0%

Emergency Dept.

93%

54%

0%

Using a similar approach, Table 7 also shows the results for the emergency department data for all presentations from 1st July 2008 to 1st June 2009, which consisted of 107,269 records. This data consists of date of presentation and the age of patient. With the 0% threshold 93% of the records would have to be suppressed, whereas only 54% would be suppressed for the 5% threshold, and none for the 20% threshold.

Selection of Threshold

An important decision when using the above models is selecting which of the three uniqueness threshold to use: 0%, 5%, or 20%. The most stringent uniqueness threshold of zero percent would be appropriate for datasets that are released to the public. This threshold would result in the most suppression and aggregation. The most permissive 20% threshold can be used when disclosing data to trusted recipients where the overall risks are quite low. This larger threshold would result in the least suppression and aggregation.

To assist with deciding which of the thresholds is most appropriate under a broad set of conditions, three general criteria have been proposed in the context of secondary use [7072]:

  • Mitigating controls that are in place at the data recipient's organization.

Mitigating controls evaluate the extent to which the data recipient has good security and privacy practices in place. A recent checklist can be used for evaluating the extent to which mitigating controls have been implemented [73]. The fewer security and privacy practices that the data recipient has in place, the lower the threshold that should be used.

  • The extent to which a disclosure (inadvertent or otherwise) constitutes an invasion of privacy for the patients.

Additional file 2 contains a set of items that have been developed based on the literature to evaluate the invasion-of-privacy construct [7479]. This set of items was subsequently reviewed by a panel of 12 Canadian privacy experts for completeness, redundancy, and clarity. The greater the risk of an invasion of privacy, the lower the threshold that should be used.

  • The extent to which the data recipient is motivated and capable of re-identifying the data.

Additional file 2 contains a set of items that have been developed based on the literature to evaluate the motives and capacity construct [8083]. This construct captures the fact that some data recipients can be trusted more than others (e.g., researchers vs. making data available to the general public). The set of items was subsequently reviewed by a panel of 12 Canadian privacy experts for completeness, redundancy, and clarity. The greater the risk that the data recipient is motivated and has the capacity to re-identify the database, the lower the threshold that should be used.

Admittedly, the use of these checklists remains qualitative, but they do provide a starting point for deciding what an appropriate threshold should be.

Limitations

The FSAs that were included in our analysis were from urban areas in Canada. As described in Additional file 1, the reason is that the census tract information from the census file that we used is only defined for urban areas. Therefore, FSAs from rural areas were not covered. However, it should be noted that the majority of the Canadian population lives in urban areas.

Our analysis was based on data from the 2001 census. There will be changes in the population over time and therefore the models may not be an accurate reflection of uniqueness the further from 2001 we are. Future studies should replicate this research on subsequent census data (the 2006 census data was not available in the Statistics Canada RDC when we conducted this study).

We used the estimated uniqueness values as the correct values, and validated our prediction model on that basis. However, the uniqueness estimate will not be perfect and such errors will negatively affect the overall accuracy of the 5% and 20% prediction models.

The MaxCombs value can only be computed for quasi-identifiers with a finite number of response categories. Continues variables that are not discretized cannot be sensibly captured using our approach.

Conclusions

Disclosure control practices for small geographic areas often result in health datasets that have significantly reduced utility. These practices include the suppression of records from individuals in small geographic areas, the aggregation of small geographic areas into larger ones, suppression of the non-geographic variables, or generalization of the non-geographic variables. Previous work has used a rather stringent definition of a small geographic area: when it has no unique individuals on the potentially identifying variables (quasi-identifiers). However, less stringent thresholds have been used in the past for the disclosure of health datasets: 5% uniqueness and 20% uniqueness.

In this paper we develop models to determine whether urban FSAs in Canada are too small by the 5% and 20% criteria by analyzing 2001 census data. We have also provided a set of concrete guidelines to help custodians decide which one these thresholds to use. Within this framework, a data custodian can manage the amount of geographic suppression or aggregation in proportion to the risks of disclosing a particular dataset.

Declarations

Acknowledgements

This work was funded by the GeoConnections program of Natural Resources Canada, the Public Health Agency of Canada, the Ontario Centers of Excellence, and the Natural Sciences and Engineering Research Council of Canada. We wish to thank David Paton (Canadian Institute for Health Information) for his feedback on an earlier version of this paper. We also wish to thank our panel of privacy experts for reviewing the items we used to evaluate risk described in Additional file 2.

This study was approved by the research ethics board of the Children's Hospital of Eastern Ontario Research Institute.

Authors’ Affiliations

(1)
Children's Hospital of Eastern Ontario Research Institute
(2)
Pediatrics, Faculty of Medicine, University of Ottawa
(3)
GIS Infrastructure, Office of Public Health Practice, Public Health Agency of Canada
(4)
Ottawa Hospital Research Institute
(5)
Children's Hospital of Eastern Ontario

References

  1. Safran C, Bloomrosen M, Hammond E, Labkoff S, S K-F, Tang P, Detmer D: Toward a national framework for the secondary use of health data: An American Medical Informatics Association white paper. Journal of the American Medical Informatics Association. 2007, 14: 1-9. 10.1197/jamia.M2273.View ArticlePubMedPubMed CentralGoogle Scholar
  2. Roy D, Fournier F: Secondary use of personal information held on national electronic health record systems. 2007, Centre for Bioethics, Clinical Research Institute of Montreal (study commissioned by the Office of the Privacy Commissioner of Canada)Google Scholar
  3. Kosseim P, Brady M: Policy by procrastination: Secondary use of electronic health records for health research purposes. McGill Journal of Law and Health. 2008, 2: 5-45.Google Scholar
  4. Black C, McGrail K, Fooks C, Baranek P, Maslove L: Data, Data, Everywhere -- Improving access to population health and health services research data in Canada. 2005, Centre for Health Services and Policy Research and Canadian Policy Research NetworksGoogle Scholar
  5. Willison D, Gibson E, McGrail K: A roadmap to research uses of electronic health information. CIHR Health Information Summit: 20-21. 2008, October , TorontoGoogle Scholar
  6. PWC Healthcare: Transforming healthcare through secondary use of health data. 2009, Dallas: PriceWaterhouseCoopersGoogle Scholar
  7. Boulos M: Towards evidence-based, GIS-driven national spatial health information infrastructure and surveillance services in the United Kingdom. International Journal of Health Geographics. 2004, 3 (1):
  8. O'Dwyer LA, Burton DL: Potential meets reality: GIS and public health research in Australia. Australian and New Zealand Journal of Public Health. 1998, 22 (7): 819-823. 10.1111/j.1467-842X.1998.tb01500.x.View ArticlePubMedGoogle Scholar
  9. Ricketts TC: Geographic information systems and public health. Annual Review of Public Health. 2003, 24: 1-6. 10.1146/annurev.publhealth.24.100901.140924.View ArticlePubMedGoogle Scholar
  10. Cromley EK: GIS and Disease. Annual Review of Public Health. 2003, 24: 7-24. 10.1146/annurev.publhealth.24.012902.141019.View ArticlePubMedGoogle Scholar
  11. Brindley P, Maheswaran R: My favourite software: geographic information systems. Journal of Public Health Medicine. 2002, 24 (2): 149-10.1093/pubmed/24.2.149.View ArticlePubMedGoogle Scholar
  12. Richards TB, Croner CM, Rushton G, Brown CK, Fowler L: Geographic information systems and public health: mapping the future. Public Health Reports. 1999, 114: 359-373. 10.1093/phr/114.4.359.View ArticlePubMedPubMed CentralGoogle Scholar
  13. Ricketts T: Geographic information systems and public health. Annual Review of Public Health. 2003, 24: 1-6. 10.1146/annurev.publhealth.24.100901.140924.View ArticlePubMedGoogle Scholar
  14. McLafferty S: GIS and health care. Annual Review of Public Health. 2003, 24: 25-42. 10.1146/annurev.publhealth.24.012902.141012.View ArticlePubMedGoogle Scholar
  15. Cromley E: GIS and disease. Annual Review of Public Health. 2003, 24: 7-24. 10.1146/annurev.publhealth.24.012902.141019.View ArticlePubMedGoogle Scholar
  16. Mugge R: Issues in protecting confidentiality in national health statistics. Proceedings of the Social Statistics Section, American Statistical Association. 1983, 592-594.Google Scholar
  17. Mackie C, Bradburn N: Improving access to and confidentiality of research data: Report of a workshop. 2000, Washington: The National Academies PressGoogle Scholar
  18. Croner C: Public health, GIS, and the Internet. Annual Review of Public Health. 2003, 24: 57-82.View ArticlePubMedGoogle Scholar
  19. Gibson Justice: Mike Gordon and The Minister of Health and Privacy Commissioner of Canada. 2008, Federal Court of CanadaGoogle Scholar
  20. El Emam K, Kosseim P: Privacy Interests in Prescription Records, Part 2: Patient Privacy. IEEE Security and Privacy. 2009, 7 (2): 75-78. 10.1109/MSP.2009.47.View ArticleGoogle Scholar
  21. Hawala S: Enhancing the "100,000" rule: On the variation of percent of uniques in a microdata sample and the geographic area size identified on the file. Proceedings of the Annual Meeting of the American Statistical Association: 5-9. 2001, August , St. LouisGoogle Scholar
  22. Greenberg B, Voshell L: Relating risk of disclosure for microdata and geographic area size. Proceedings of the Section on Survey Research Methods, American Statistical Association. 1990, 450-455.Google Scholar
  23. Greenberg B, Voshell L: The geographic component of disclosure risk for microdata. Statistical Research Division Report Series. 1990, Washington: Bureau of the CensusGoogle Scholar
  24. Zayatz L, Massell P, Steel P: Disclosure limitation practices and research at the US Census Bureau. Netherlands Official Statistics. 1999, 14 (Spring): 26-29.Google Scholar
  25. Zayatz L: Disclosure avoidance practices and research at the US Census Bureau: An update. Statistical Research Division Report Series. 2005, Washington: US Census BureauGoogle Scholar
  26. Hawala S: Microdata disclosure protection research and experiences at the US census bureau. Presented at the Workshop on Microdata: 21-22. 2003, August , StockholmGoogle Scholar
  27. Marsh C, Dale A, Skinner C: Safe data versus safe settings: Access to microdata from the British census. International Statistical Review. 1994, 62 (1): 35-53. 10.2307/1403544.View ArticleGoogle Scholar
  28. Statistics Canada: Canadian Community Health Survey (CCHS) Cycle 3.1 (2005) Public Use Microdata File (PUMF) User Guide. 2006Google Scholar
  29. Willenborg L, de Waal T: Statistical Disclosure Control in Practice. 1996, New York: Springer-VerlagView ArticleGoogle Scholar
  30. Fefferman N, O'Neil E, Naumova E: Confidentiality and confidence: Is data aggregation a means to achieve both?. Journal of Public Health Policy. 2005, 26 (4): 430-449. 10.1057/palgrave.jphp.3200029.View ArticlePubMedGoogle Scholar
  31. Willenborg L, Mokken R, Pannekoek J: Microdata and disclosure risks. Proceedings of the Annual Research Conference of US Bureau of the Census. 1990, 167-180.Google Scholar
  32. Olson K, Grannis S, Mandl K: Privacy protection versus cluster detection in spatial epidemiology. American Journal of Public Health. 2006, 96 (11): 2002-2008. 10.2105/AJPH.2005.069526.View ArticlePubMedPubMed CentralGoogle Scholar
  33. Marceau D: The scale issue in social and natural sciences. Canadian Journal of Remote Sensing. 1999, 25 (4): 347-356.View ArticleGoogle Scholar
  34. Bivand R: A review of spatial statistical techniques for location studies. 1998, Bergen: Norwegian School of Economics and Business AdministrationGoogle Scholar
  35. Ratcliffe J: The Modifiable Areal Unit Problem. [http://www.jratcliffe.net/research/maup.htm]
  36. Bethlehem J, Keller W, Pannekoek J: Disclosure control of microdata. Journal of the American Statistical Association. 1990, 85 (409): 38-45. 10.2307/2289523.View ArticleGoogle Scholar
  37. El Emam K, Brown A, Abdelmalik P: Evaluating Predictors of Geographic Area Population Size Cutoffs to Manage Re-identification Risk. Journal of the American Medical Informatics Association. 2009, 16 (2): 256-266. 10.1197/jamia.M2902.View ArticlePubMedPubMed CentralGoogle Scholar
  38. Howe H, Lake A, Shen T: Method to assess identifiability in electronic data files. American Journal of Epidemiology. 2007, 165 (5): 597-601. 10.1093/aje/kwk049.View ArticlePubMedGoogle Scholar
  39. Howe H, Lake A, Lehnherr M, Roney D: Unique record identification on public use files as tested on the 1994-1998 CINA analytic file. North American Association of Central Cancer Registries. 2002Google Scholar
  40. El Emam K: Heuristics for de-identifying health data. IEEE Security and Privacy. 2008, 72-75.Google Scholar
  41. Dalenius T: Finding a needle in a haystack or identifying anonymous census records. Journal of Official Statistics. 1986, 2 (3): 329-336.Google Scholar
  42. El Emam K, Jabbouri S, Sams S, Drouet Y, Power M: Evaluating common de-identification heuristics for personal health information. Journal of Medical Internet Research. 2006, 8 (4): e28-10.2196/jmir.8.4.e28.View ArticlePubMedPubMed CentralGoogle Scholar
  43. El Emam K, Jonker E, Sams S, Neri E, Neisa A, Gao T, Chowdhury S: Pan-Canadian De-Identification Guidelines for Personal Health Information. 2007, Ottawa: Prepared for the Office of the Privacy Commissioner of CanadaGoogle Scholar
  44. The International Organization for Standardization: ISO/TS 25237: Health Informatics - Pseudonymization. 2008, Geneva: The International Organization for StandardizationGoogle Scholar
  45. Bow C, Waters N, Faris P, Seidel J, Galbraith P, Knudtson M, Ghali W: Accuracy of city postal code coordinates as a proxy for location of residence. International Journal of Health Geographics. 2004, 3 (5):
  46. Ng E, Wilkins R, Perras A: How far is it to the nearest hospital? Calculating distances using the Statistics Canada Postal Code Conversion file. Health Reports. 1993, 5: 179-183.PubMedGoogle Scholar
  47. Mackillop W, Zhang-Salomons J, Groome P, Pazat L, Holowaty E: Socioeconomic status and cancer survival in Ontario. Journal of Clinical Oncology. 1997, 15: 1680-1689.PubMedGoogle Scholar
  48. Spasoff A, Gilkes D: Up-to-date denominators: Evaluation of taxation family for public health planning. Canadian Journal of Public Health. 1994, 85: 413-417.PubMedGoogle Scholar
  49. Demissie K, Hanley J, Menzies D, Joseph L, Ernst P: Agreement in measuring socio-economic status: Area-based versus individual measures. Chronic Diseases in Canada. 2000, 21: 1-7.PubMedGoogle Scholar
  50. Guernsey J, Dewar R, Weerasinghe S, Kirkland S, Veugelers P: Incidence of cancer in sydney and Cape breton County, Nova Scotia 1979-1997. Canadian Journal of Public Health. 2000, 91: 285-292.PubMedGoogle Scholar
  51. Sweeney L: Uniqueness of Simple Demographics in the US Population. 2000, Carnegie Mellon University, Laboratory for International Data PrivacyGoogle Scholar
  52. Golle P: Revisiting the uniqueness of simple demographics in the US population. Workshop on Privacy in the Electronic Society. 2006Google Scholar
  53. Skinner C, Holmes D: Estimating the re-identification risk per record in microdata. Journal of Official Statistics. 1998, 14 (4): 361-372.Google Scholar
  54. Chen G, Keller-McNulty S: Estimation of identification disclosure risk in microdata. Journal of Official Statistics. 1998, 14 (1): 79-95.Google Scholar
  55. Zayatz L: Estimation of the percent of unique population elements on a microdata file using the sample. 1991, Washington: US Bureau of the CensusGoogle Scholar
  56. Hosmer D, Lemeshow S: Applied Logistic Regression. 1989, New York: John Wiley & SonsGoogle Scholar
  57. Jaccard J: Interaction Effects in Logistic Regression. 2001, London: Sage PublicationsView ArticleGoogle Scholar
  58. Simon S, Lesage J: The Impact of Collinearity Involving the Intercept Term on the Numerical Accuracy of Regression. Computer Science in Economics and Management. 1988, 1: 137-152. 10.1007/BF00427160.View ArticleGoogle Scholar
  59. Pergibon D: Logistic Regression Diagnostics. The Annals of Statistics. 1981, 9 (4): 705-724. 10.1214/aos/1176345513.View ArticleGoogle Scholar
  60. King G, Zeng L: Logistic regression in rare events data. Political Analysis. 2001, 9 (2): 137-163.View ArticleGoogle Scholar
  61. Scott A, Wild C: Fitting logistic models under case-control or choice based sampling. Journal of the Royal Statistical Society. 1986, 48 (2): 170-182.Google Scholar
  62. Lowe W: Rare events research. Encyclopedia of Social Measurement. Edited by: Kempf-Leonard K. 2005, Cambridge: Academic Press, 293-297. full_text.View ArticleGoogle Scholar
  63. Ruiz-Gazen A, Villa N: Storms prediction: Logistic regression vs. random forests for unbalanced data. Case Studies in Business, Industry and Government Statistics. 2007, 1 (2): 91-101.Google Scholar
  64. Metz C: Basic Principles of ROC Analysis. Seminars in Nuclear Medicine. 1978, VIII (4): 283-298. 10.1016/S0001-2998(78)80014-2.View ArticleGoogle Scholar
  65. DeLong E, DeLong D, Clarke-Pearson D: Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics. 1988, 44: 837-845. 10.2307/2531595.View ArticlePubMedGoogle Scholar
  66. Hanley J, McNeil B: The Meaning and Use of the Area Under a Receiver Operating Characteristic Curve. Diagnostic Radiology. 1982, 143 (1): 29-36.PubMedGoogle Scholar
  67. Spiegelhalter D: Probabilistic Prediction in Patient Management in Clinical Trials. Statistics in Medicine. 1986, 5: 421-433. 10.1002/sim.4780050506.View ArticlePubMedGoogle Scholar
  68. Cherkassky V, Muller F: Learning from data: concepts, theory, and methods. 1998, New York: WileyGoogle Scholar
  69. Alpaydin E: Introduction to machine learning. 2004, Cambridge: MIT PressGoogle Scholar
  70. El Emam K: De-identifying health data for secondary use: A framework. 2008, Ottawa: CHEO Research InstituteGoogle Scholar
  71. Jabine T: Statistical disclosure limitation practices of United States statistical agencies. Journal of Official Statistics. 1993, 9 (2): 127-454.Google Scholar
  72. Jabine T: Procedures for restricted data access. Journal of Official Statistics. 1993, 9 (2): 537-589.Google Scholar
  73. El Emam K, Dankar F, Vaillancourt R, Roffey T, Lysyk M: Evaluating patient re-identification risk from hospital prescription records. Canadian Journal of Hospital Pharmacy. 2009, 62 (4): 307-319.Google Scholar
  74. Treasury Board of Canada Secretariat: Privacy impact assessment guidelines: A framework to manage privacy risks. 2002, Government of CanadaGoogle Scholar
  75. Treasury Board of Canada Secretariat: Guidance document: Taking privacy into account before making contracting decisions. 2006, Government of CanadaGoogle Scholar
  76. Canadian Institutes of Health Research: CIHR best practices for protecting privacy in health research. 2005, Ottawa: Public Works and Government Services CanadaGoogle Scholar
  77. Canadian Institutes of Health Research: Secondary use of personal information in health research: Case studies. 2002, Ottawa: Public Works and Government Services CanadaGoogle Scholar
  78. Office of the Privacy Commissioner of Canada: Key Steps for Organizations in Responding to Privacy Breaches. 2007, [http://www.priv.gc.ca/information/guide/2007/gl_070801_02_e.pdf]Google Scholar
  79. Office of the Saskatchewan Information and Privacy Commissioner: Privacy breach guidelines. [http://www.oipc.sk.ca/Resources/Privacy%20Breach%20Guidelines1%20(3):.pdf]
  80. Elliot M, Dale A: Scenarios of attack: the data intruder's perspective on statistical disclosure risk. Netherlands Official Statistics. 1999, 14 (Spring): 6-10.Google Scholar
  81. Sweeney L: Guaranteeing anonymity when sharing medical data: The Datafly system. Proceedings of the American Medical Informatics Association Symposium, 25-29 October 1997; Nashville. JAMIA. 1997, 51-55. Symposium Suppl
  82. Willenborg L, de Waal T: Elements of Statistical Disclosure Control. 2001, New York: Springer-VerlagView ArticleGoogle Scholar
  83. Pong R, Pitblado J: Don't take geography for granted ! Some methodological issues in measuring geographic distribution of physicians. Canadian Journal of Rural Medicine. 2001, 6 (2): 103-112.Google Scholar
  84. Pre-publication history

    1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6947/10/18/prepub

Copyright

© El Emam et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement