Table 2 Stage-specific predictive performance metric of the index classifier against the reference standard (TNM stage) (N = 1375)
Metric (95% CI) | I | II | III | IV |
|---|---|---|---|---|
Sensitivity | 0.99 (0.98, 0.99) | 0.82 (0.75, 0.89) | 0.64 (0.55, 0.74) | 0.92 (0.88, 0.95) |
Specificity | 0.94 (0.92, 0.96) | 0.97 (0.96, 0.98) | 0.99 (0.99, 0.99) | 0.98 (0.97, 0.99) |
Positive predictive value | 0.97 (0.97, 0.98) | 0.74 (0.67, 0.81) | 0.96 (0.91, 0.99) | 0.88 (0.84, 0.93) |
Negative predictive value | 0.98 (0.96, 0.99) | 0.98 (0.97, 0.99) | 0.97 (0.96, 0.98) | 0.99 (0.98, 0.99) |
F1 score | 0.98 (0.98, 0.99) | 0.78 (0.72, 0.83) | 0.77 (0.70, 0.84) | 0.90 (0.87, 0.93) |
c-statistic | 0.97 (0.96, 0.98) | 0.90 (0.86, 0.93) | 0.82 (0.77, 0.87) | 0.95 (0.93, 0.97) |