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Table 1 Logistic multivariate regression results

From: Detection of statin-induced rhabdomyolysis and muscular related adverse events through data mining technique

Variables

OR

SE

z

P-value

95% CI

Intercept

0.000

0.000

− 13.160

 < 0.001*

(0.000, 0.000)

Statin groups

0. Low-dose hydrophilic

1.000

1. High-dose hydrophilic

0.811

0.565

− 0.300

0.763

(0.207, 3.177)

2. Low-dose lipophilic

0.743

0.306

− 0.720

0.470

(0.331, 1.664)

3. High-dose lipophilic

1.227

0.523

0.480

0.630

(0.533, 2.829)

Medications

Antifungals

2.865

2.095

1.440

0.150

(0.683, 12.008)

Clarithromycin

2.777

1.297

2.190

0.029*

(1.112, 6.934)

Ticagrelor

2.220

1.344

1.320

0.188

(0.678, 7.271)

Cyclosporine

2.127

1.306

1.230

0.219

(0.638, 7.089)

Carvedilol

1.534

0.442

1.490

0.138

(0.872, 2.697)

Colchicine

1.327

0.459

0.820

0.413

(0.674, 2.613)

Amiodarone

0.654

0.319

− 0.870

0.384

(0.251, 1.703)

Digoxin

0.594

0.441

− 0.700

0.483

(0.138, 2.549)

Diltiazem

0.865

0.451

− 0.280

0.781

(0.311, 2.405)

Ezetimibe

0.712

0.256

− 0.950

0.344

(0.352, 1.439)

Ciprofloxacin

0.419

0.196

− 1.860

0.063

(0.167, 1.049)

Gemfibrozil

0.508

0.513

− 0.670

0.503

(0.070, 3.674)

Other covariables

AST (> 30 U/L)

35.294

20.824

6.040

 < 0.001*

(11.104, 112.181)

eGFR (< 60 mL/min/1.73 m2)

2.360

0.617

3.280

0.001*

(1.413, 3.940)

Hypertension

1.774

0.504

2.020

0.044*

(1.017, 3.095)

Age (> 65 years old)

0.640

0.157

− 1.820

0.069

(0.396, 1.036)

LDL (> 125 mg/dL)

0.409

0.122

− 3.010

0.003*

(0.228, 0.733)

Variables

Odds Ratio

Std. Err

z

P-value

95% CI

Interaction effects of high-dose lipophilic statin

 + Clarithromycin

5.662

4.908

2.000

0.046*

(1.035, 30.962)

 + Antifungals

5.840

6.071

1.700

0.090

(0.761, 44.796)

 + Clarithromycin

 + Antifungals

16.219

18.309

2.470

0.014*

(1.775, 148.226)

 + Ticagrelor

4.526

4.256

1.610

0.108

(0.717, 28.584)

 + Cyclosporine

4.337

4.157

1.530

0.126

(0.662, 28.389)

 + Carvedilol

3.127

2.430

1.470

0.142

(0.681, 14.344)

 + Colchicine

2.705

2.180

1.230

0.217

(0.558, 13.125)

  1. * p < 0.05