Table 2 Descriptive summary statistics for the training dataset
Dependent: Outcome | Â | Painful_neuropathy | Painless_neuropathy | Total | p value |
|---|---|---|---|---|---|
Center | Dundee | 1 (0.2) | 3 (0.9) | 4 (0.4) |  < 0.001 |
| Â | Imperial | 134 (21.8) | 43 (13.4) | 177 (18.9) | Â |
| Â | Oxford | 327 (53.3) | 230 (71.7) | 557 (59.6) | Â |
| Â | Technion | 152 (24.8) | 45 (14.0) | 197 (21.1) | Â |
EQ5D_Index | Median (IQR) | 0.7 (0.5 to 0.7) | 0.8 (0.7 to 0.9) | 0.7 (0.6 to 0.8) |  < 0.001 |
Depression_tscore | Median (IQR) | 52.0 (44.7 to 59.4) | 44.7 (38.2 to 50.9) | 49.4 (42.2 to 55.9) |  < 0.001 |
Anxiety_tscore | Median (IQR) | 49.4 (40.7 to 58.4) | 40.7 (37.1 to 50.8) | 45.9 (37.1 to 56.4) |  < 0.001 |
Sleep_Disturbance_tscore | Median (IQR) | 56.3 (51.2 to 60.4) | 54.3 (48.1 to 59.4) | 56.3 (50.1 to 59.4) | 0.016 |
Trauma | No | 271 (44.1) | 149 (46.4) | 420 (44.9) | 0.005 |
| Â | Yes | 146 (23.8) | 45 (14.0) | 191 (20.4) | Â |
| Â | (Missing) | 197 (32.1) | 127 (39.6) | 324 (34.7) | Â |
Hospital_stay | No | 355 (57.8) | 174 (54.2) | 529 (56.6) | 0.261 |
| Â | Yes | 60 (9.8) | 21 (6.5) | 81 (8.7) | Â |
| Â | (Missing) | 199 (32.4) | 126 (39.3) | 325 (34.8) | Â |
TIPIExtraversion | Median (IQR) | 4.0 (2.5 to 5.0) | 4.0 (3.0 to 5.0) | 4.0 (3.0 to 5.0) | 0.246 |
TIPIAgreeableness | Median (IQR) | 5.0 (4.0 to 6.0) | 5.0 (4.0 to 6.0) | 5.0 (4.0 to 6.0) | 0.345 |
TIPIConscientiousness | Median (IQR) | 6.0 (4.5 to 6.5) | 6.0 (5.0 to 7.0) | 6.0 (4.5 to 6.5) | 0.188 |
TIPIEmotionalStability | Median (IQR) | 4.5 (3.5 to 6.5) | 5.5 (4.0 to 6.5) | 5.0 (4.0 to 6.5) | 0.005 |
TIPIOpenness | Median (IQR) | 5.0 (4.0 to 6.0) | 4.5 (4.0 to 5.5) | 5.0 (4.0 to 6.0) | 0.654 |
Ever_smoked_status | No | 203 (33.1) | 108 (33.6) | 311 (33.3) | 0.150 |
| Â | Yes | 211 (34.4) | 86 (26.8) | 297 (31.8) | Â |
| Â | (Missing) | 200 (32.6) | 127 (39.6) | 327 (35.0) | Â |
Alcohol_consumption | Never | 151 (24.6) | 48 (15.0) | 199 (21.3) | 0.010 |
| Â | Less than 1Â day per month | 82 (13.4) | 37 (11.5) | 119 (12.7) | Â |
| Â | 1 to 3Â days per month | 52 (8.5) | 23 (7.2) | 75 (8.0) | Â |
| Â | 1 or 2Â days per week | 68 (11.1) | 34 (10.6) | 102 (10.9) | Â |
| Â | 3 or 4Â days per week | 25 (4.1) | 19 (5.9) | 44 (4.7) | Â |
| Â | Daily or almost daily | 37 (6.0) | 32 (10.0) | 69 (7.4) | Â |
| Â | (Missing) | 199 (32.4) | 128 (39.9) | 327 (35.0) | Â |
Alcohol_consumption_likert | Median (IQR) | 1.0 (0.0 to 3.0) | 2.0 (1.0 to 4.0) | 1.0 (0.0 to 3.0) |  < 0.001 |
Alcohol_status | No | 151 (24.6) | 48 (15.0) | 199 (21.3) | 0.006 |
| Â | Yes | 264 (43.0) | 145 (45.2) | 409 (43.7) | Â |
| Â | (Missing) | 199 (32.4) | 128 (39.9) | 327 (35.0) | Â |
PCS_score | Median (IQR) | 15.0 (6.0 to 27.0) | 4.0 (0.0 to 11.0) | 10.0 (3.0 to 23.0) |  < 0.001 |
MNSI_score | Median (IQR) | 6.0 (4.0 to 7.0) | 3.0 (2.0 to 4.0) | 5.0 (3.0 to 7.0) |  < 0.001 |
DN4_score | Median (IQR) | 5.0 (4.0 to 7.0) | 2.0 (1.0 to 3.0) | 4.0 (3.0 to 6.0) |  < 0.001 |
Age | Median (IQR) | 68.0 (59.0 to 73.0) | 70.0 (63.0 to 75.0) | 68.0 (60.0 to 74.0) |  < 0.001 |
Gender | Female | 206 (33.6) | 92 (28.7) | 298 (31.9) | 0.156 |
| Â | Male | 408 (66.4) | 228 (71.0) | 636 (68.0) | Â |
| Â | (Missing) | 0 (0.0) | 1 (0.3) | 1 (0.1) | Â |
BMI | Median (IQR) | 29.3 (26.0 to 33.3) | 28.4 (25.5 to 32.2) | 29.0 (26.0 to 33.0) | 0.031 |
HBA1C | Median (IQR) | 7.5 (6.7 to 8.7) | 7.2 (6.5 to 8.2) | 7.4 (6.6 to 8.5) | 0.001 |
Diabetes_Duration | Median (IQR) | 12.0 (6.0 to 17.0) | 15.5 (9.2 to 23.8) | 13.5 (8.0 to 20.0) | 0.040 |
Cholesterol | Median (IQR) | 4.0 (3.6 to 5.0) | 4.2 (3.5 to 4.6) | 4.1 (3.5 to 4.6) | 0.460 |
LDL | Median (IQR) | 2.3 (1.8 to 3.1) | 1.9 (1.7 to 2.5) | 2.0 (1.7 to 2.8) | 0.186 |
HDL | Median (IQR) | 1.1 (0.9 to 1.3) | 1.2 (1.0 to 1.3) | 1.2 (1.0 to 1.3) | 0.692 |
Creatinine | Median (IQR) | 75.0 (65.0 to 85.0) | 80.0 (67.0 to 89.0) | 78.0 (67.0 to 89.0) | 0.735 |
TRIGLYCERIDES | Median (IQR) | 1.7 (1.3 to 2.0) | 1.5 (1.2 to 2.0) | 1.7 (1.2 to 2.0) | 0.514 |