Fig. 5

Neighborhood search example. A neighborhood search with a depth of two was performed using ACE2 as the start node. The neighbors of ACE2 were filtered so they only represent genes that have a gene–gene relationship in STRING with an interaction score >  = 700, representing high confidence interactions. The second layer of edges represent drug-gene interactions from DGIdb (interaction score >  = 2) and CORD-19 (at least two sources of evidence). The right panel shows support texts for flavonoids inhibiting DPP4, a gene that interacts with ACE2. The graph in the figure represents a subset of the results; The full results can be viewed by following the search settings in the tutorial section of the KGEV website (http://covid19nlp.wglab.org/tutorial)