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Table 1 Characteristics of the patient cohort

From: Combining adult with pediatric patient data to develop a clinical decision support tool intended for children: leveraging machine learning to model heterogeneity

Patient characteristics

Pediatric patients (< = 18 years of age) N = 2792

Adult patients (> = 19 years of age) N = 39,417

Standardized difference

Age (Mean, SD)

8.26 (6.25)

61.0 (14.1)

4.822*

Sex (N, %)

 Male

1433 (51.3%)

18,452 (46.8%)

0.090

 Female

1359 (48.7%)

20,965 (53.2%)

 

Race (N, %)

 Non-Hispanic white

1555 (55.7%)

29,219 (74.1%)

0.501*

 Non-Hispanic black

615 (22.0%)

7662 (19.4%)

 

 Hispanic

265 (9.5%)

728 (1.8%)

 

 Other

357 (12.8%)

1808 (4.6%)

 

Height (Mean, SD)

48.1 (15.8)

66.9 (4.15)

1.626*

Weight (Mean, SD)

1260 (1010)

3110 (809)

2.021*

BMI (N, %)

 Underweight

1417 (50.8%)

366 (0.9%)

1.973*

 Normal

981 (35.1%)

8377 (21.3%)

 

 Overweight

176 (6.3%)

12,639 (32.1%)

 

 Obese

188 (6.7%)

18,013 (45.7%)

 

 None

30 (1.1%)

22 (0.1%)

 

Previous healthcare utilization (Mean, SD)

 Hospital encounters

0.602 (1.49)

0.276 (0.749)

0.277*

 Ambulatory encounters

13.9 (15.8)

17.2 (18.8)

0.192*

 Emergency department encounters

0.219 (1.92)

0.204 (0.970)

0.009

Comorbidities (Top 15: N, %)

 Cardiovascular disease

870 (31.2%)

23,713 (60.2%)

0.609*

 Psychiatric disease

614 (22.0%)

19,117 (48.5%)

0.578*

 Hypertension

152 (5.4%)

17,722 (45.0%)

1.022*

 Diabetes

20 (0.7%)

2973 (17.7%)

0.614*

 Atherosclerotic CVD

2 (0.1%)

5133 (13.0%)

0.542*

 Coronary artery disease

1 (0.0%)

4589 (11.6%)

0.511*

 COPD

13 (0.5%)

2764 (7.0%)

0.350*

 AFIB

0 (0.0%)

2405 (6.1%)

0.360*

 Congestive heart failure

16 (0.6%)

1551 (3.9%)

0.228*

 Peripheral vascular disease

12 (0.4%)

1511 (3.8%)

0.237*

 Diabetic renal

3 (0.1%)

1375 (3.5%)

0.257*

 CVA/TIA

56 (2.0%)

963 (2.4%)

0.030

 Liver disease

9 (0.3%)

938 (2.4%)

0.179*

 Pulmonary hypertension

54 (1.9%)

692 (1.8%)

0.013

 End-stage renal disease

13 (0.5%)

496 (1.3%)

0.086

Concurrent medications (Top 15: N, %)

 Statins

3 (0.1%)

14,408 (36.6%)

1.068*

 Antiplatelet

139 (5.0%)

13,383 (34.0%)

0.786*

 Opioid

128 (4.6%)

11,768 (29.9%)

0.710*

 Diuretics

175 (6.3%)

11,116 (28.2%)

0.607*

 Hypertension medication

126 (4.5%)

10,394 (26.4%)

0.635*

 Beta blocker

46 (1.6%)

9757 (24.8%)

0.726*

 Anti-arrhythmic

39 (1.4%)

8577 (21.8%)

0.671*

 ACE inhibitor

65 (2.3%)

7935 (20.1%)

0.588*

 Calcium channel blocker

47 (1.7%)

7822 (19.8%)

0.613*

 Angiotensin receptor blocker

14 (0.5%)

6320 (16.0%)

0.588*

 Anticoagulant

32 (1.1%)

2976 (7.6%)

0.318*

 Insulin

8 (0.3%)

2859 (7.3%)

0.372*

 Oral diabetic

0 (0.0%)

2592 (6.6%)

0.375*

 Nitrates

0 (0.0%)

2031 (5.2%)

0.330*

 Digoxin

31 (1.1%)

122 (0.3%)

0.095

  1. *Standardized difference greater than 0.10 indicates meaningful difference between cohorts