Table 1 Knowledge base on drugs, drug features and regimen features included in the treatment recommender for drug resistant tuberculosis

Drugs

Amikacin, Bedaquiline, Clofazimine, Cycloserine, Delamanid, Ethambutol, Ethionamide, Imipenem, high or standard dose Isoniazid, Levofloxacin, Linezolid, Meropenem, high or standard dose Moxifloxacin, Para-aminosalicylic acid, Pretomanid, Prothionamide, Pyrazinamide, Rifabutin, high or standard dose Rifampicin, Streptomycin, Terizidone

Drug features

Route of administration, toxicity, QT prolongation, cost, early bactericidal activity, bactericidal activity, sterilizing activity, mechanism of action, propensity to acquire resistance

Regimen features

Core or companion drug^a [30], prevention of acquired resistance^a, four different mechanisms of action^a, fully oral regimen^a, cost^b, toxicity^b, QT prolongation^a, high early bactericidal activity^a, early bactericidal activity^b, high early bactericidal activity^a, bactericidal activity^b, high sterilizing activity^a, sterilizing activity^b, synergism^b, antagonism^b, contra-indications^a, same drug class^a, first line drugs included^b