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Table 1 Extracted data of the included studies

From: Can minimal clinically important differences in patient reported outcome measures be predicted by machine learning in patients with total knee or hip arthroplasty? A systematic review

Study

Fontana et al. [2]

Harris et al. [27]*

Huber et al. [28]*

Katakam et al. [59]

Zhang et al. [60]

Kunze et al. [29]

Country of data origin

US

US

UK

US

Not reported

US

Surgical procedure

THA/TKA

TKA

THA/TKA

TKA

TKA

THA

PROMs/MCID values

HOOS JR: 17.7

KOOS JR: 13.6

SF-36 (MCS + PCS): 5.0 (both)

KOOS Total: 91.8

KOOS JR: 20.8

KOOS Pain: 25.0

KOOS Symptoms: 14.3

KOOS ADL: 24.6

KOOS Quality of Life: 12.5

KOOS Recreation: 17.5

EQ VAS Hip: 11

EQ VAS Knee: 10

OHS: 8a

OKS: 7a

KOOS: MCID value not reported

PROMIS Global PF: MCID value not reported

PROMIS Global MH: MCID value not reported

NRS Pain: MCID value not reported

SF-36 PCS: 10.0

SF-36 MCS: 5.0

WOMAC: 15.0

EQ VAS: Not reported

MCID calculation method

Anchor-based

Distribution-based

Anchor-based

Distribution-based (VAS)

Anchor-based (OKS, OHS)

Distribution-based

Anchor-based

Distribution-basedb

Time-difference surgery to post-surgery PROM collection (months)

24

12

12

12

24

24

Number of observations

7,239 (THA)

6,480 (TKA)

587

30,524 (THA)

34,110 (TKA)

744

2840

616

Number of featuresc

66–97

6–106

81 (candidate predictors)

24 (candidate predictors)

18 (WOMAC); 19 (other PROMs)

8

Applied machine learning methods

LASSO

Random forest

Support vector machine

LASSO

Gradient boosting machine

Quadratic discriminant analysis

Extreme gradient boosting machine

Random forest

Multistep adaptive elastic net

Neural network

Naive Bayes

k-nearest neighbours

Boosted logistic regression

Stochastic gradient boosting

Random forest

Support vector machine

Neural network

Elastic-net penalized logistic regression

Support vector machine

LASSO

Random forest

Extreme gradient boosting

Stochastic gradient boosting

Random forest

Support vector machine

Neural network

Elastic net penalized logistic regression

Ratio of training to test dataset

80:20

No test dataset

About 1:1 (dataset of the next year)

80:20

80:20

80:20

Cross-validation applied in the training dataset

Yes

Yes

Yes

Yes

Yes

Yes

Outlier detection and analysis performed?

Not reported

Not reported

Not reported

Not reported

Not reported

Not reported

Missing value management reported?

Yes

Not reported

Yes

Yes

Yes

Yes

Feature preprocessing performed?

Yes

Not reported

Not reported

Not reported

Not reported

Not reported

Imbalanced data adjustment performed?

Not reported

Not reported

Yes

Not reported

Yes

Not reported

AUC/c-statistice

0.89 (not reported)

0.72 (not reported)d

Not reported on test data

0.77 (0.74–0.79)

SVM: 0.95 (0.94–0.97)

XGB: 0.95 (0.94–0.97)

0.97 (0.94–0.99)

J-statistic

–

–

0.59 (not reported)

–

–

–

F1-measure

–

–

0.78 (not reported)

–

SVM: 0.85 (not reported)

XGB: 0.86 (not reported)

–

Sensitivity

–

–

0.82 (not reported)

–

SVM: 93.1 (not reported)

XGB: 95.6 (not reported)

–

Specificity

–

–

0.77 (not reported)

–

SVM: 86.8 (not reported)

XGB: 84.9 (not reported)

–

Accuracy

 

–

0.79 (not reported), balanced accuracy

–

–

–

Brier Scoree

Not reported

LASSO (KOOS Pain): 0.16 (not reported)

LASSO (KOOS Symptoms): 0.17 (not reported)

LASSO (KOOS ADL): 0.17 (not reported)

GBM (KOOS PAIN): 0.16 (not reported)

QDA (KOOS PAIN): 0.16 (not reported)

Not reported

0.15 (0.12–0.19)

SVM: 0.12 (not reported)

XGB: 0.11 (not reported)

0.054 (0.047–0.062)

Best predictive model

Logistic LASSO

Random forest

LASSO, Gradient boosting machine, QDA (Pain)

LASSO (KOOS Symptoms + KOOS ADL)

Extreme gradient boosting

Neural Network

Elastic-net penalized logistic regression

Support vector machine (SVM)

Extreme gradient boosting (XGB)

Random forest

Best predictive PROM

SF-36 MCS

KOOS Pain

KOOS Symptoms

KOOS ADL

EQ VAS (hip)

KOOS

SF-36 MCS

EQ VAS

Predictive task

Classification

Classification

Classification

Classification

Classification

Classification

  1. HOOS JR, Hip disability and osteoarthritis outcome score joint replacement; KOOS JR, Knee injury and osteoarthritis outcome score joint replacement; SF-36 MCS, Short form-36 mental component score; SF-36 PCS, Short form-36 physical component score; EQ, EuroQol; VAS, Visual analog scale; OKS, Oxford Knee Score; OHS, Oxford Hip Score; LASSO, Least absolute shrinkage and selection operator; AUC, area under the receiver operating curve; QDA, Quadratic discriminant analysis; ADL, Activities of daily life; JR, Joint replacement
  2. *Also applied LR
  3. aValue was taken from literature
  4. bThis value was calculated on postoperative score distribution
  5. cFinally included in the models when not otherwise stated
  6. dResult from the training dataset with fivefold cross validation as no AUC was reported on test data
  7. eConfidence intervals (95% if not otherwise specified) in parenthesis