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Table 2 Subgroup comparison of 7-day estimated mortality obtained using RL-oxygen algorithm and critical care physician decision guidance

From: Reinforcement learning assisted oxygen therapy for COVID-19 patients under intensive care

Subgroups

Estimated mortality (%)

Average oxygen (L/min)

RL-oxygen

Physician

RL-oxygen

Physician

Overall

5.37 (0.22)

7.94 (0.27)

19.24 (0.07)*

20.52 (0.07)

Male

6.13 (0.12)*

8.53 (0.14)

21.20 (0.09)*

22.66 (0.09)

Female

2.18 (0.11)*

2.99 (0.12)

6.33 (0.07)

6.41 (0.07)

Age

 50–65

1.19 (0.08)*

1.74 (0.09)

25.54 (0.12)*

22.27 (0.12)

 65–75

4.13 (0.14)*

5.43 (0.16)

19.63 (0.12)*

22.73 (0.12)

 75–80

14.76 (0.3)*

20.39 (0.34)

19.79 (0.14)*

21.45 (0.16)

 ≥ 80

15.86 (0.57)*

21.73 (0.65)

14.28 (0.18)*

18.96 (0.26)

Body mass index (kg/m2)

 < 25

7.74 (0.18)*

11.10 (0.21)

19.27 (0.11)*

20.58 (0.12)

 25–30

7.38 (0.19)*

9.21 (0.21)

23.39 (0.13)*

24.5 (0.14)

 30–35

2.72 (0.15)*

5.30 (0.21)

22.91 (0.16)*

21.42 (0.17)

 ≥ 35

5.35 (0.28)*

5.44 (0.28)

19.53 (0.18)*

22.78 (0.21)

Hyperlipidemia

7.43 (0.13)*

9.47 (0.14)

20.11 (0.09)*

20.94 (0.09)

Coronary artery disease

8.55 (0.18)*

11.39 (0.21)

18.13 (0.12)*

20.04 (0.11)

Heart failure

11.25 (0.23)*

12.59 (0.25)

18.35 (0.11)

18.22 (0.13)

Hypertension

6.96 (0.11)*

8.79 (0.13)

21.2 (0.08)

21.25 (0.08)

Diabetes

7.73 (0.15)*

8.25 (0.15)

25.22 (0.11)*

20.31 (0.1)

Asthma or chronic obstructive pulmonary

11.98 (0.32)*

17.67 (0.38)

15.57 (0.15)*

19.68 (0.18)

Dementia

10.71 (0.46)*

15.82 (0.56)

15.57 (0.23)*

14.19 (0.23)

Stroke

9.15 (0.31)*

12.95 (0.37)

21.78 (0.15)*

15.94 (0.19)

  1. Categorical variables are summarized with frequencies (percentages) unless otherwise indicated. Continuous variables are summarized as the mean (standard error) of biomarkers
  2. *Variables indicate RL-oxygen is significantly different from physicians (p-value < 0.001)