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Table 3 Top 10 alerts related to drug interactions between January 2016 and December 2018

From: Safer prescription of drugs: impact of the PREFASEG system to aid clinical decision-making in primary care in Catalonia

Original active ingredient Conflicting active ingredient Alerts generated Acceptance (%)
Ibuprofen Acetylsalicylic acid 97,847 19
Amlodipine Simvastatin 85,358 24
Naproxen Acetylsalicylic acid 64,913 16
Simvastatin Amlodipine 59,453 26
Dexketoprofen Acetylsalicylic acid 32,455 16
Acenocoumarol Simvastatin 31,349 29
Simvastatin Acenocoumarol 31,349 26
Tramadol and paracetamol Citalopram 27,479 24
Tramadol and paracetamol Sertraline 26,872 24
Diclofenac Acetylsalicylic acid 25,292 24
Enoxaparin Acetylsalicylic acid 23,715 16