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Table 1 Results of our analysis of solutions for privacy-preserving data sharing

From: Privacy-preserving data sharing infrastructures for medical research: systematization and comparison

Approach

Year of publication

Category

1. Privacy protection

2. Usefulness

1. Safe data

2. Safe settings

3. Safe outputs

1. De-duplication

2. Flexibility

3. Scalability

SHRINE/i2b2

2008

Distributed data analysis

Yes

No

Yesb

No

Specific

Yes

dataSHIELD

2010

Distributed data analysis

Yes

No

Yesb

No

Generic

Yes

OHDSI

2014

Distributed data analysis

Yes

No

Yesb

No

Generic

Yes

Personal Health Train

2017

Distributed data analysis

Yes

No

Yesb

No

Generic

Yes

Clinerion

2015

Distributed data analysis

Yes

No

Yesb

No

Specific

Yes

TriNetX

2015

Distributed data analysis

Yes

No

Yesb

No

Specific

Yes

MedCo

2018

Secure multi-party computation

Yesa

Yes

Yes

No

Specific

No

ShareMIND

2008

Secure multi-party computation

Yesa

Yes

Yes

Yes

Generic

No

Scottish National Safe Haven

2015

Data enclave

No

Yes

Yes

Yes

Generic

Yes

Virtual Research Data Center

2014

Data enclave

No

Yes

Yes

Yes

Specific

Yes

  1. aThe processed data is encrypted individual-level data and thus safe
  2. bSafe Outputs is an implicit result of providing Safe Data as input