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Table 1 Results of our analysis of solutions for privacy-preserving data sharing

From: Privacy-preserving data sharing infrastructures for medical research: systematization and comparison

Approach Year of publication Category 1. Privacy protection 2. Usefulness
1. Safe data 2. Safe settings 3. Safe outputs 1. De-duplication 2. Flexibility 3. Scalability
SHRINE/i2b2 2008 Distributed data analysis Yes No Yesb No Specific Yes
dataSHIELD 2010 Distributed data analysis Yes No Yesb No Generic Yes
OHDSI 2014 Distributed data analysis Yes No Yesb No Generic Yes
Personal Health Train 2017 Distributed data analysis Yes No Yesb No Generic Yes
Clinerion 2015 Distributed data analysis Yes No Yesb No Specific Yes
TriNetX 2015 Distributed data analysis Yes No Yesb No Specific Yes
MedCo 2018 Secure multi-party computation Yesa Yes Yes No Specific No
ShareMIND 2008 Secure multi-party computation Yesa Yes Yes Yes Generic No
Scottish National Safe Haven 2015 Data enclave No Yes Yes Yes Generic Yes
Virtual Research Data Center 2014 Data enclave No Yes Yes Yes Specific Yes
  1. aThe processed data is encrypted individual-level data and thus safe
  2. bSafe Outputs is an implicit result of providing Safe Data as input