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Table 8 Image analysis

From: A systematic review of the applications of Expert Systems (ES) and machine learning (ML) in clinical urology

Art

Mdl

Dom

Subdomain

Variables

Output

System training

Validation

Statistical outcome

[142]

ANN

CaP

Radiotherapy dose planning

Patient prostate contour points (anterior, posterior and 5 lateral)

Anterior, posterior and lateral beam

12–68 patients record of radiotherapy treatment planning

Average asymmetry of ANN and acceptance by dosimetrists Small field prostate (n = 133) and for large field prostate (n = 64)

Average asymmetry of ANN 0.20% and acceptance by dosimetrists was 96% (small field prostate) and 88% for large field prostate

[143]

ANN

CaP

Diagnosis of localised disease from TRUS

Pixel distribution and grey levels of the TRUS images

Benign, malignant with Gleason grading

53 images of benign and malignant sample images from 5 patients

Compare to histology results of 500 pictures from 61 patients post RRP for localised disease in one centre

Sp 99%, Se 83%, true positive for isoechoic is 97%

[144]

ANN

LDA

CaP

progression post RPP

Prostate volume, PSA, Pathology morphometric variables LDA

Progression or no

Progression t2n0 post RRP, 228 patients from one centre

ROC, Sp, Se, LOO

39 cases

Ac 70%, Se 55%, Sp 85%

[144]

ANN LVQ

CaP

progression post RPP

Prostate volume, PSA, Pathology morphometric variables

Progression or no

Progression t2n0 post RRP, 228 patients from one centre

ROC, Sp, Se, LOO

39 cases

Ac 90%, Se 95%, Sp 85%,

[144]

ANN LVQPAK

CaP

progression post RPP

Prostate volume, PSA, Pathology morphometric variables

Progression or no

Progression t2n0 post RRP, 228 patients from one centre

ROC, Sp, Se, LOO

39 cases

Ac 83%, Se 85%, Sp 80%

[144]

ANN MLFF-bp

CaP

progression post RPP

Prostate volume, PSA, Pathology morphometric variables

Progression or no

Progression t2n0 post RRP, 228 patients from one centre

ROC, Sp, Se, LOO

39 cases

Ac 76%, Se 73%, Sp 80%

[145]

kNN

CaP

TRUS cancer image analysis

Image pixels segmented by tissue descriptor (spatial grey level dependence)

Predict cancer

Images of 202 patients with suspected CaP at one centre

87 randomly selected patients Comparison to other classifiers and ROC

AUC 0.6

[146]

ANN

CaP

TRUS Image segmentation

Pixel’s colour values from TRUS images

TRUS image segmentation

212 CaP TRUS data

Overlap measure (compared to expert segmented boundary) on 10 random images

81% mean overlap measurement

[147]

ANN

CaP

MRI cancer diagnosis

256 MRSI spectra (resonance intensities at given PPM)

Cancer or benign

5308 voxels of 18 patients with CaP in a retrospective study

15% validation

ROC Se, Sp

AUC 0.95, Se 50%, Sp 99%

[147]

ANN

CaP

MRI cancer diagnosis

256 MRSI spectra (resonance intensities at given PPM), peripheral and transition zone, periurethral and outside region

Cancer or benign

5308 voxels of 18 patients with CaP in a retrospective study

15% CV validation

ROC Se, Sp

AUC 0.97, Se 62%, Sp 99%

[148]

SVM

CaP

Diagnosis of cancer from pMRI images

Image segmentation then clustering voxels

Cancer or benign

16 pMRI images with CaP

Correlation coefficients of voxel parameters

Mean accuracy of 84%

[149]

ANN

Bca

Image histology analysis

Image histology analysis (measurements of the segmentation of nuclei and other features)

Benign and malignant

141 randomly chosen cell images (30%)

329 cell images (70%)

ROC, Sp, Se

Sp 100%, Se 82%, PPV 96%, NPV 80%, Ac 88%

[150]

FCM

Bca

Diagnosis of tumour

Bladder wall segmentation and tumour region extraction

To detect bladder abnormalities, four volume-based morphological features: bent rate, shape index, wall thickness, and bent rate difference between the inner and outer surfaces

Bladder neoplasm

16 Bladder tumour MRI images

Overlap Ratio (OR)

OR 86.3%

[151]

ANN

Bca

Transitional cell cytology analysis

Cytology image analysis and pixel variations as variables

Cancer or benign

16 cytology images

comparison to experts, × 2 test

75% concordance with the experts

[152]

ANN

Nlt

Spectroscopy stone analysis

Absorbance infra-red spectrum of 91 wave lengths

Stone composition

160 and 57 stone mixtures

Predictive accuracy, root mean square error on 36 independent stone samples

Overall good predictive value

  1. Expert Systems in this application analysed images from histology and radiological scans to learn patterns that are correlated to a specific diagnosis. They have proven to be effective in this domain and they facilitated diagnosis of cancer and even delivering radiotherapy dosage