Patient similarity analytics for explainable clinical risk prediction

Fang, Hao Sen Andrew; Tan, Ngiap Chuan; Tan, Wei Ying; Oei, Ronald Wihal; Lee, Mong Li; Hsu, Wynne

doi:10.1186/s12911-021-01566-y

BMC Medical Informatics and Decision Making

Table 2 List of variables (and their description) included in computing degree of similarity

From: Patient similarity analytics for explainable clinical risk prediction

No	Variables	Description
Demographic
1	Age	Age at base visit date
Duration of disease (years)
2	Duration of diabetes	Duration of diabetes at base visit date
3	Duration of hypertension	Duration of hypertension at base visit date
4	Duration of hyperlipidemia	Duration of hyperlipidemia at base visit date
Biomarkers
5	Body mass index	Body mass index at base visit
6	HbA1c^a level (%)	Hemoglobin A1c level at base visit date
7	Systolic BP^b (mmHg)	Systolic blood pressure at base visit date
8	Diastolic BP^b (mmHg)	Diastolic blood pressure at base visit date
9	LDL^c level (mmol/L)	Low-density lipoprotein level at base visit date
10	HDL^d level (mmol/L)	High-density lipoprotein level at base visit date
11	TG^e level (mmol/L)	Triglyceride level at base visit date
Anti-diabetic medications: daily dose
12	Metformin	Total daily dose of each anti-diabetic medication at base visit
13	Glipizide
14	Gliclazide
15	Tolbutamide
16	Acarbose
17	Sitagliptin
18	Linagliptin
19	Dapagliflozin
20	Empagliflozin
21	Rapid-acting insulin
22	Isophane insulin
23	Insulin glargine
24	Insulin detemir
25	Pre-mixed insulin
Anti-hypertensive medications: daily dose
26	Candesartan	Total daily dose of each anti-hypertensive medication at base visit
27	Captopril
28	Enalapril
29	Lisinopril
30	Losartan
31	Perindopril
32	Telmisartan
33	Valsartan
34	Atenolol
35	Bisoprolol
36	Propranolol
37	Amlodipine
38	Nifedipine
39	Hydrochlorothiazide
40	Indapamide
41	Spironolactone
42	Hydralazine
43	Methyldopa
44	Amiloride
Lipid-lowering medications: daily dose
45	Lovastatin	Total daily dose of each lipid-lowering medication at base visit
46	Pravastatin
47	Simvastatin
48	Atorvastatin
49	Rosuvastatin
50	Fenofibrate
51	Gemfibrozil
52	Ezetimibe
53	Cholestyramine
Anti-diabetic medication class (count)
54	Biguanides	Count of number of medications in each class at base visit ^f
55	Sulphonylureas
56	Alpha-glucosidase inhibitors
57	Dipeptidyl peptidase 4 inhibitors
58	Sodium-glucose co-transporter 2 inhibitors
59	Insulin
Anti-hypertensive medication class (count)
60	Angiotensin-converting enzyme inhibitors and Angiotensin II receptor blockers	Count of number of medications in each class at base visit ^f
61	Beta blockers
62	Calcium channel blockers
63	Diuretics
64	Other anti-hypertensive classes
Anti-hypertensive medication class (count)
65	Statins	Count of number of medications in each class at base visit ^f
66	Other lipid-lowering medications
Medication purpose (count)
67	Anti-diabetic medications	Count of number of medications for each condition at base visit
68	Anti-hypertensive medications
69	Lipid-lowering medications

^a HbA1c: Hemoglobin A1c
^b BP: Blood pressure
^c LDL: Low-density lipoprotein
^d HDL: High-density lipoprotein
^e TG: Triglyceride
^f For these variables, the count is either 0 or 1

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