Table 4 Structure and medical content of the DA for previvors with BRCA1/2 mutations following incorporation of the results of the focus group discussions (DA A)
| Â | Topic | Content |
|---|---|---|
Information | Introduction | Addressing the target group and target definition Notes on authors, funding source and use of the decision aid |
(1) Overview | Overview of the contents of this decision aid | |
(2) What does a mutation in the BRCA1 or BRCA2 gene mean? | Function of the non-mutated BRCA genes Significance of hereditary BRCA mutations Average risks of breast cancer and ovarian cancer each subdivided into BRCA1 and BRCA2 mutations Personal risk of breast cancer and ovarian cancer | |
(3) What consequences can I expect based on the result of my genetic test? | Overview of potential preventive options Intensified breast cancer screening programme: Aims, reliability, procedure, implementation, pros/cons, overview table Risk-reducing bilateral mastectomy: Effect on risk of developing breast cancer Forms of mastectomy, pros/cons, overview table Forms of breast reconstruction, pros/cons, overview table Risk-reducing removal of both ovaries and Fallopian tubes: Effect on risk of developing ovarian cancer and survival, surgical procedure, option for hormone replacement therapy, pros/cons, overview table FAQs on other aspects | |
Support of decision-making | (4) How do I work out my own perspective? A guide to making an informed decision | Worksheet 1: Comparison of preventive options Worksheet 2: Significance of certain aspects in terms of your own cancer risk (clarifying values and preferences; box-ticking) Worksheet 3: A step-by-step guide to making your decision (your situation, clarifying values and preferences; free-form notes) Worksheet 4: Helping you prepare for your consultation with your doctor |
(5) Other helpful information | Points of contact for personal advice, self-help What can I do for myself? Tips for additional information material Glossary Contact addresses and links References | |
(6) Appendix | Fact boxes for women with BRCA1 and BRCA2 mutations: Average risks of developing breast cancer: Lifetime, age and time-related (10Â year) risks Average risks of developing ovarian cancer: Lifetime, age and time-related (10-year) risks |