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Table 3 The summarized 8 topic groups and 44 criteria categories of Chinese eligibility criteria, as well as ratio (count) in 19,185 criteria sentences, average incidence and prevalence in 272 HCC related clinical trials

From: Semantic categorization of Chinese eligibility criteria in clinical trials using machine learning methods

Topic group

Criteria category

Ratio (count)

Average incidence

Prevalence

Health status

Disease

23.40% (4489)

2.7904 (759)

68.75% (187)

Symptom

0.36% (70)

0.0110 (3)

1.10% (3)

Sign

1.64% (314)

0.0294 (8)

2.94% (8)

Pregnancy-related activity

4.65% (893)

0.4118 (112)

33.82% (92)

Neoplasm status

0.14% (26)

0.1397 (38)

11.03% (30)

Non-neoplasm disease stage

0.62% (118)

0.0074 (2)

0.74% (2)

Allergy intolerance

2.80% (538)

0.2132 (58)

19.49% (53)

Organ or tissue status

1.67% (321)

0.2574 (70)

21.32% (58)

Life expectancy

0.66% (127)

0.1838 (50)

17.65% (48)

Oral related

0.16% (31)

0.0000 (0)

0.00% (0)

Treatment or health care

Pharmaceutical substance or drug

3.77% (724)

0.1213 (33)

9.93% (27)

Therapy or surgery

6.96% (1336)

1.2463 (339)

54.78% (149)

Device

0.40% (77)

0.0221 (6)

2.21% (6)

Nursing

0.06% (12)

0.0000 (0)

0.00% (0)

Diagnostic or lab test

Diagnostic

5.19% (995)

0.6103 (166)

40.81% (111)

Laboratory examinations

4.93% (945)

0.8934 (243)

29.41% (80)

Risk assessment

2.86% (549)

0.7757 (211)

42.65% (116)

Receptor status

0.04% (8)

0.0074 (2)

0.74% (2)

Demographic characteristics

Age

4.12% (790)

0.2353 (64)

22.79% (62)

Special patient characteristic

0.31% (59)

0.0074 (2)

0.74% (2)

Literacy

0.17% (32)

0.0000 (0)

0.00% (0)

Gender

0.11% (21)

0.0000 (0)

0.00% (0)

Education

0.07% (14)

0.0000 (0)

0.00% (0)

Address

0.17% (32)

0.0110 (3)

1.10% (3)

Ethnicity

0.08% (15)

0.0000 (0)

0.00% (0)

Ethical consideration

Consent

5.74% (1101)

0.4632 (126)

38.60% (105)

Enrollment in other studies

2.35% (451)

0.1176 (32)

11.76% (32)

Researcher decision

1.98% (379)

0.1324 (36)

12.50% (34)

Capacity

0.73% (140)

0.0184 (5)

1.84% (5)

Ethical audit

0.02% (3)

0.0037 (1)

0.37% (1)

Compliance with protocol

1.92% (368)

0.2022 (55)

17.65% (48)

Lifestyle choice

Addictive behavior

1.27% (244)

0.0221 (6)

2.21% (6)

Bedtime

0.02% (4)

0.0000 (0)

0.00% (0)

Exercise

0.10% (20)

0.0000 (0)

0.00% (0)

Diet

0.24% (46)

0.0000 (0)

0.00% (0)

Alcohol consumer

0.05% (10)

0.0000 (0)

0.00% (0)

Sexual related

0.02% (3)

0.0000 (0)

0.00% (0)

Smoking status

0.22% (42)

0.0000 (0)

0.00% (0)

Blood donation

0.08% (16)

0.0000 (0)

0.00% (0)

Data or Patient source

Encounter

0.22% (43)

0.0000 (0)

0.00% (0)

Disabilities

0.02% (4)

0.0000 (0)

0.00% (0)

Healthy

0.11% (22)

0.0000 (0)

0.00% (0)

Data accessible

0.28% (53)

0.0294 (8)

2.94% (8)

Others

Multiple

19.29% (3700)

1.4632 (398)

78.68% (214)