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Table 3 The summarized 8 topic groups and 44 criteria categories of Chinese eligibility criteria, as well as ratio (count) in 19,185 criteria sentences, average incidence and prevalence in 272 HCC related clinical trials

From: Semantic categorization of Chinese eligibility criteria in clinical trials using machine learning methods

Topic group Criteria category Ratio (count) Average incidence Prevalence
Health status Disease 23.40% (4489) 2.7904 (759) 68.75% (187)
Symptom 0.36% (70) 0.0110 (3) 1.10% (3)
Sign 1.64% (314) 0.0294 (8) 2.94% (8)
Pregnancy-related activity 4.65% (893) 0.4118 (112) 33.82% (92)
Neoplasm status 0.14% (26) 0.1397 (38) 11.03% (30)
Non-neoplasm disease stage 0.62% (118) 0.0074 (2) 0.74% (2)
Allergy intolerance 2.80% (538) 0.2132 (58) 19.49% (53)
Organ or tissue status 1.67% (321) 0.2574 (70) 21.32% (58)
Life expectancy 0.66% (127) 0.1838 (50) 17.65% (48)
Oral related 0.16% (31) 0.0000 (0) 0.00% (0)
Treatment or health care Pharmaceutical substance or drug 3.77% (724) 0.1213 (33) 9.93% (27)
Therapy or surgery 6.96% (1336) 1.2463 (339) 54.78% (149)
Device 0.40% (77) 0.0221 (6) 2.21% (6)
Nursing 0.06% (12) 0.0000 (0) 0.00% (0)
Diagnostic or lab test Diagnostic 5.19% (995) 0.6103 (166) 40.81% (111)
Laboratory examinations 4.93% (945) 0.8934 (243) 29.41% (80)
Risk assessment 2.86% (549) 0.7757 (211) 42.65% (116)
Receptor status 0.04% (8) 0.0074 (2) 0.74% (2)
Demographic characteristics Age 4.12% (790) 0.2353 (64) 22.79% (62)
Special patient characteristic 0.31% (59) 0.0074 (2) 0.74% (2)
Literacy 0.17% (32) 0.0000 (0) 0.00% (0)
Gender 0.11% (21) 0.0000 (0) 0.00% (0)
Education 0.07% (14) 0.0000 (0) 0.00% (0)
Address 0.17% (32) 0.0110 (3) 1.10% (3)
Ethnicity 0.08% (15) 0.0000 (0) 0.00% (0)
Ethical consideration Consent 5.74% (1101) 0.4632 (126) 38.60% (105)
Enrollment in other studies 2.35% (451) 0.1176 (32) 11.76% (32)
Researcher decision 1.98% (379) 0.1324 (36) 12.50% (34)
Capacity 0.73% (140) 0.0184 (5) 1.84% (5)
Ethical audit 0.02% (3) 0.0037 (1) 0.37% (1)
Compliance with protocol 1.92% (368) 0.2022 (55) 17.65% (48)
Lifestyle choice Addictive behavior 1.27% (244) 0.0221 (6) 2.21% (6)
Bedtime 0.02% (4) 0.0000 (0) 0.00% (0)
Exercise 0.10% (20) 0.0000 (0) 0.00% (0)
Diet 0.24% (46) 0.0000 (0) 0.00% (0)
Alcohol consumer 0.05% (10) 0.0000 (0) 0.00% (0)
Sexual related 0.02% (3) 0.0000 (0) 0.00% (0)
Smoking status 0.22% (42) 0.0000 (0) 0.00% (0)
Blood donation 0.08% (16) 0.0000 (0) 0.00% (0)
Data or Patient source Encounter 0.22% (43) 0.0000 (0) 0.00% (0)
Disabilities 0.02% (4) 0.0000 (0) 0.00% (0)
Healthy 0.11% (22) 0.0000 (0) 0.00% (0)
Data accessible 0.28% (53) 0.0294 (8) 2.94% (8)
Others Multiple 19.29% (3700) 1.4632 (398) 78.68% (214)