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Table 1. Characteristics of patients in development set

From: Development, validation, and proof-of-concept implementation of a two-year risk prediction model for undiagnosed atrial fibrillation using common electronic health data (UNAFIED)

Variable Overall N = 53552 AF (cases) N = 31474 No AF (controls) N = 22078 P value
Demographics
 Age, mean (SD), years 66.56 (13.42) 71.53 (11.87) 59.48 (12.28) < .0001
 Age, no. (%) years < .0001
  40–55 12474 (23.3%) 3287 (10.4%) 9187 (41.6%)  
  56–66 13676 (25.5%) 6949 (22.1%) 6727 (30.5%)  
  67–77 14822 (27.7%) 10630 (33.8%) 4192 (19.0%)  
  > 77 12580 (23.5%) 10608 (33.7%) 1972 (8.9%)  
 Sex < .0001
  Female 29044 (54.2%) 15561 (49.4%) 13483 (61.1%)  
  Male 24507 (45.8%) 15913 (50.6%) 8594 (38.9%)  
 Race, no. (%) < .0001
  White 41493 (77.5%) 24636 (78.3%) 16857 (76.4%)  
  Black 3225 (6.0%) 1690 (5.4%) 1535 (7.0%)  
  Other 8834 (16.5%) 5148 (16.4%) 3686 (16.7%)  
 Ethnicity, no. (%) < .0001
  Not Hispanic or Latino 37219 (69.5%) 22681 (72.1%) 14538 (65.8%)  
  Hispanic or Latino 828 (1.5%) 402 (1.3%) 426 (1.9%)  
  Unknown 15505 (29.0%) 8391 (26.7%) 7114 (32.2%)  
 Insurance type, No. (%) < .0001
  Commercial 28416 (53.1%) 16115 (51.2%) 12301 (55.7%)  
  Medicaid 7324 (13.7%) 4289 (13.6%) 3035 (13.7%)  
  Medicare 11141 (20.8%) 8432 (26.8%) 2709 (12.3%)  
  Other/Unknown 6671 (12.5%) 2638 (8.4%) 4033 (18.3%)  
Additional diagnoses and laboratory variables included in final model
 Acute heart diseasea, no. (%) 9782 (18.3%) 7874 (25.0%) 1908 (8.6%) < .0001
 Albumin < 3.5, no. (%), g/dL 4110 (7.7%) 3264 (10.4%) 846 (3.8%) < .0001
 Body mass index, no. (%), kg/m2 < .0001
  Missing 33926 (63.4%) 18468 (58.7%) 15458 (70.0%)  
  Normal weight: 18.5–24.9 4008 (7.5%) 2684 (8.5%) 1324 (6.0%)  
  Obese: ≥ 30 9258 (17.3%) 6139 (19.5%) 3119 (14.1%)  
  Overweight: 25–29.9 6013 (11.2%) 3926 (12.5%) 2087 (9.5%)  
  Underweight: < 18.5 347 (0.6%) 257 (0.8%) 90 (0.4%)  
 COPD, no. (%) 7891 (14.7%) 5909 (18.8%) 1982 (9.0%)  < . 0001
 Kidney diseaseb, no. (%) 4783 (8.9%) 4060 (12.9%) 723 (3.3%) < .0001
 Shock, no. (%) 3365 (6.3%) 2593 (8.2%) 772 (3.5%)  
  1. aIf troponin > 0.04 or diagnosis of myocardial infarction
  2. bBUN > 20 or (creatinine > 1.1 for female) or (creatinine > 1.3 for male) or (diagnoses of Chronic Kidney Disease or End Stage Renal Disease)