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Table 8 Two sample T Test results for distinguishing clinical characteristics by subgroup

From: Unsupervised phenotyping of sepsis using nonnegative matrix factorization of temporal trends from a multivariate panel of physiological measurements

Clinical characteristic Mean (SD) within subgroup Two-sample T Test t-statistic (significance level) for difference in means between subgroups
1 2 3 1 and 2 1 and 3 2 and 3
Gender (is male) 0.59
(0.49)
0.60
(0.49)
0.50
(0.50)
− 0.695
(P = 0.487)
4.954
(P < 1e−3)
6.664
(P < 1e−3)
Age 73.12
(14.56)
67.91
(16.27)
59.92
(18.24)
9.194
(P < 1e−3)
22.094
(P < 1e−3)
15.429
(P < 1e−3)
Weight (kg) 84.25
(35.08)
83.01
(24.32)
79.37
(25.54)
1.144
(P = 0.253)
4.659
(P < 1e−3)
4.661
(P < 1e−3)
Elixhauser index 3.53
(6.90)
5.65
(7.12)
2.37
(6.59)
− 8.334
(P < 1e−3)
4.957
(P < 1e−3)
16.136
(P < 1e−3)
Day-1 sofa score 6.51
(2.60)
8.65
(3.38)
6.50
(2.53)
− 17.575
(P < 1e−3)
0.104
(P = 0.917)
23.652
(P < 1e−3)
ICU LOS (day) 3.14
(4.67)
6.23
(7.10)
4.21
(5.52)
− 13.561
(P < 1e−3)
− 5.846
(P < 1e−3)
10.83
(P < 1e−3)
30-Day mortality 0.17
(0.38)
0.28
(0.45)
0.10
(0.30)
− 7.411
(P < 1e−3)
6.01
(P < 1e−3)
16.323
(P < 1e−3)
In-hospital mortality 0.12
(0.32)
0.26
(0.43)
0.07
(0.26)
− 8.95
(P < 1e−3)
4.729
(P < 1e−3)
16.893
(P < 1e−3)
Coagulopathy 0.10
(0.30)
0.30
(0.46)
0.12
(0.32)
− 13.388
(P < 1e−3)
− 1.823
(P = 0.068)
15.217
(P < 1e−3)
Liver disease 0.06
(0.24)
0.17
(0.38)
0.09
(0.29)
− 9.313
(P < 1e−3)
− 3.451
(P = 0.001)
7.975
(P < 1e−3)
Alcohol abuse 0.06
(0.24)
0.11
(0.31)
0.13
(0.33)
− 4.404
(P < 1e−3)
− 6.333
(P < 1e−3)
− 2.335
(P = 0.020)
Pulmonary circulation 0.10
(0.30)
0.11
(0.31)
0.06
(0.24)
− 1.117
(P = 0.264)
3.897
(P < 1e−3)
5.833
(P < 1e−3)
Neurological disease 0.15
(0.36)
0.13
(0.34)
0.22
(0.41)
1.511
(P = 0.131)
− 4.817
(P < 1e−3)
− 7.522
(P < 1e−3)
Chronic pulmonary 0.06
(0.24)
0.11
(0.31)
0.13
(0.33)
1.587
(P = 0.113)
2.033
(P = 0.042)
0.440
(P = 0.660)
Hypertension 0.70
(0.46)
0.65
(0.48)
0.49
(0.50)
2.756
(P = 0.006)
12.536
(P < 1e−3)
11.386
(P < 1e−3)
Fluid electrolyte imbalance 0.42
(0.49)
0.62
(0.49)
0.35
(0.48)
− 11.192
(P < 1e−3)
4.006
(P < 1e−3)
18.530
(P < 1e−3)
Cardiac arrhythmias 0.39
(0.49)
0.37
(0.48)
0.22
(0.42)
0.829
(P = 0.407)
10.473
(P < 1e−3)
10.991
(P < 1e−3)
Congestive heart failure 0.32
(0.47)
0.31
(0.46)
0.15
(0.36)
1.041
(P = 0.298)
12.585
(P < 1e−3)
12.926
(P < 1e−3)
Deficiency anemias 0.23
(0.42)
0.29
(0.45)
0.21
(0.41)
− 3.796
(P = 0.000)
1.072
(P = 0.284)
5.949
(P < 1e−3)
Diabetes uncomplicated 0.28
(0.45)
0.26
(0.44)
0.17
(0.37)
1.463
(P = 0.144)
8.270
(P < 1e−3)
7.646
(P < 1e−3)
Renal failure 0.28
(0.45)
0.29
(0.45)
0.07
(0.25)
− 0.490
(P = 0.625)
18.517
(P < 1e−3)
20.819
(P < 1e−3)
Hypothyroidism 0.15
(0.36)
0.13
(0.34)
0.11
(0.31)
1.662
(P = 0.097)
4.063
(P < 1e−3)
2.642
(P = 0.008)
Depression 0.12
(0.32)
0.13
(0.34)
0.14
(0.35)
− 1.093
(P = 0.275)
− 2.016
(P = 0.0439)
1.055
(P = 0.291)
Valvular disease 0.12
(0.32)
0.13
(0.34)
0.07
(0.26)
− 0.993
(P = 0.321)
4.668
(P < 1e−3)
6.549
(P < 1e−3)
Peripheral vascular 0.11
(0.32)
0.12
(0.33)
0.05
(0.23)
− 0.602
(P = 0.547)
6.533
(P < 1e−3)
8.076
(P < 1e−3)
  1. P value smaller than 0.0001 are shown in scientific notation; Missing values in clinical characteristics were dropped in T Test