Table 5 AUROC results when predicting the outcomes within 3Â years of the treatment for depression
Outcome (outcome count with partial time-at-risk/ outcome count with full time-at-risk) | Solution | Test Data 1: All patients with partial time-at-risk are removed (~ 47,000) | Test Data 2: All patients with partial time-at-risk are included (~ 125,000) | Test Data 3: All non-outcome patients with partial time-at-risk are removed |
|---|---|---|---|---|
Acute liver injury incident event (107/43) | Logistic remove lost to follow-up | 0.755 (0.67–0.84) | 0.786 (0.74–0.831) | 0.82 (0.776–0.864) |
Logistic keep lost to follow-up | 0.767 (0.683–0.851) | 0.811 (0.765–0.858) | 0.836 (0.79–0.882) | |
Logistic remove non-outcomes lost to follow-up | 0.701 (0.603–0.8) | 0.713 (0.661–0.765) | 0.852 (0.804–0.901) | |
Cox keep lost to follow-up | 0.765 (0.681–0.849) | 0.806 (0.759–0.853) | 0.846 (0.802–0.89) | |
Ventricular arrhythmia and sudden cardiac death incident event (126/32) | Logistic remove lost to follow-up | 0.797 (0.721–0.874) | 0.799 (0.762–0.837) | 0.829 (0.792–0.865) |
Logistic keep lost to follow-up | 0.809 (0.721–0.897) | 0.825 (0.787–0.862) | 0.853 (0.816–0.891) | |
Logistic remove non-outcomes lost to follow-up | 0.788 (0.706–0.871) | 0.76 (0.72–0.801) | 0.892 (0.859–0.925) | |
Cox keep lost to follow-up | 0.816 (0.731–0.902) | 0.826 (0.788–0.864) | 0.866 (0.83–0.902) | |
Ischemic stroke—all inpatient, incident event (185/94) | Logistic remove lost to follow-up | 0.832 (0.793–0.871) | 0.83 (0.805–0.854) | 0.846 (0.822–0.87) |
Logistic keep lost to follow-up | 0.829 (0.791–0.866) | 0.851 (0.829–0.874) | 0.843 (0.819–0.866) | |
Logistic remove non-outcomes lost to follow-up | 0.834 (0.798–0.87) | 0.754 (0.727–0.781) | 0.879 (0.857–0.902) | |
Cox keep lost to follow-up | 0.837 (0.799–0.874) | 0.843 (0.82–0.866) | 0.862 (0.839–0.885) | |
Acute myocardial infarction incident event (273/111) | Logistic remove lost to follow-up | 0.8 (0.759–0.841) | 0.804 (0.78–0.829) | 0.838 (0.815–0.861) |
Logistic keep lost to follow-up | 0.809 (0.768–0.85) | 0.83 (0.806–0.853) | 0.845 (0.822–0.869) | |
Logistic remove non-outcomes lost to follow-up | 0.794 (0.754–0.834) | 0.75 (0.725–0.775) | 0.889 (0.867–0.911) | |
Cox keep lost to follow-up | 0.809 (0.768–0.849) | 0.825 (0.801–0.849) | 0.861 (0.838–0.883) | |
Delirium incident event (359/148) | Logistic remove lost to follow-up | 0.818 (0.786–0.85) | 0.813 (0.793–0.833) | 0.851 (0.833–0.87) |
Logistic keep lost to follow-up | 0.832 (0.801–0.863) | 0.846 (0.828–0.864) | 0.854 (0.836–0.873) | |
Logistic remove non-outcomes lost to follow-up | 0.816 (0.784–0.847) | 0.766 (0.745–0.787) | 0.895 (0.879–0.912) | |
Cox keep lost to follow-up | 0.831 (0.801–0.862) | 0.842 (0.824–0.86) | 0.873 (0.856–0.89) | |
Gastrointestinal hemhorrage incident event (430/210) | Logistic remove lost to follow-up | 0.754 (0.721–0.787) | 0.737 (0.714–0.76) | 0.79 (0.768–0.811) |
Logistic keep lost to follow-up | 0.765 (0.732–0.798) | 0.767 (0.745–0.789) | 0.784 (0.763–0.806) | |
Logistic remove non-outcomes lost to follow-up | 0.749 (0.716–0.782) | 0.651 (0.627–0.674) | 0.84 (0.819–0.861) | |
Cox keep lost to follow-up | 0.776 (0.745–0.808) | 0.761 (0.739–0.783) | 0.81 (0.789–0.831) | |
Decreased libido incident event (643/391) | Logistic remove lost to follow-up | 0.698 (0.674–0.722) | 0.713 (0.695–0.732) | 0.703 (0.684–0.722) |
Logistic keep lost to follow-up | 0.705 (0.682–0.729) | 0.738 (0.72–0.755) | 0.667 (0.646–0.687) | |
Logistic remove non-outcomes lost to follow-up | 0.683 (0.659–0.708) | 0.582 (0.563–0.601) | 0.769 (0.751–0.788) | |
Cox keep lost to follow-up | 0.708 (0.685–0.731) | 0.73 (0.712–0.747) | 0.705 (0.687–0.724) | |
Seizure incident event (712/313) | Logistic remove lost to follow-up | 0.783 (0.757–0.809) | 0.767 (0.75–0.784) | 0.805 (0.789–0.822) |
Logistic keep lost to follow-up | 0.779 (0.753–0.806) | 0.787 (0.77–0.804) | 0.788 (0.77–0.806) | |
Logistic remove non-outcomes lost to follow-up | 0.753 (0.725–0.78) | 0.674 (0.656–0.692) | 0.849 (0.833–0.865) | |
Cox keep lost to follow-up | 0.782 (0.756–0.808) | 0.777 (0.76–0.794) | 0.815 (0.798–0.832) | |
Alopecia incident event (1268/690) | Logistic remove lost to follow-up | 0.684 (0.666–0.702) | 0.692 | 0.695 |
Logistic keep lost to follow-up | 0.687 (0.669–0.706) | 0.713 | 0.638 | |
Logistic remove non-outcomes lost to follow-up | 0.653 (0.633–0.672) | 0.547 | 0.765 | |
Cox keep lost to follow-up | 0.691 (0.673–0.71) | 0.704 | 0.698 | |
Tinnitus incident event (1419/760) | Logistic remove lost to follow-up | 0.69 (0.671–0.709) | 0.681 | 0.682 |
Logistic keep lost to follow-up | 0.691 (0.672–0.71) | 0.701 | 0.648 | |
Logistic remove non-outcomes lost to follow-up | 0.644 (0.624–0.663) | 0.538 | 0.764 | |
Cox keep lost to follow-up | 0.695 (0.676–0.713) | 0.689 | 0.702 | |
Vertigo incident event (1663/911) | Logistic remove lost to follow-up | 0.696 (0.679–0.713) | 0.699 | 0.698 |
Logistic keep lost to follow-up | 0.697 (0.68–0.714) | 0.727 | 0.665 | |
Logistic remove non-outcomes lost to follow-up | 0.672 (0.655–0.69) | 0.568 | 0.781 | |
Cox keep lost to follow-up | 0.709 (0.693–0.726) | 0.714 | 0.723 | |
Fracture incident event (2222/1002) | Logistic remove lost to follow-up | 0.76 | 0.753 | 0.783 |
Logistic keep lost to follow-up | 0.762 | 0.765 | 0.75 | |
Logistic remove non-outcomes lost to follow-up | 0.72 | 0.636 | 0.831 | |
Cox keep lost to follow-up | 0.764 | 0.755 | 0.792 | |
Hyponatremia incident event (3032/1281) | Logistic remove lost to follow-up | 0.812 | 0.81 | 0.839 |
Logistic keep lost to follow-up | 0.813 | 0.819 | 0.818 | |
Logistic remove non-outcomes lost to follow-up | 0.787 | 0.71 | 0.88 | |
Cox keep lost to follow-up | 0.812 | 0.812 | 0.846 | |
Suicide and suicidal ideation incident event (3382/1549) | Logistic remove lost to follow-up | 0.822 | 0.829 | 0.849 |
Logistic keep lost to follow-up | 0.821 | 0.839 | 0.827 | |
Logistic remove non-outcomes lost to follow-up | 0.807 | 0.702 | 0.882 | |
Cox keep lost to follow-up | 0.822 | 0.834 | 0.846 | |
Hypothyroidism incident event (4119/2330) | Logistic remove lost to follow-up | 0.77 | 0.772 | 0.776 |
Logistic keep lost to follow-up | 0.773 | 0.794 | 0.739 | |
Logistic remove non-outcomes lost to follow-up | 0.748 | 0.649 | 0.827 | |
Cox keep lost to follow-up | 0.773 | 0.777 | 0.781 | |
Hypotension incident event (4385/1877) | Logistic remove lost to follow-up | 0.793 | 0.798 | 0.831 |
Logistic keep lost to follow-up | 0.797 | 0.812 | 0.811 | |
Logistic remove non-outcomes lost to follow-up | 0.772 | 0.7 | 0.873 | |
Cox keep lost to follow-up | 0.798 | 0.803 | 0.841 | |
Constipation incident event (7865/3934) | Logistic remove lost to follow-up | 0.69 | 0.684 | 0.727 |
Logistic keep lost to follow-up | 0.688 | 0.708 | 0.673 | |
Logistic remove non-outcomes lost to follow-up | 0.663 | 0.569 | 0.791 | |
Cox keep lost to follow-up | 0.694 | 0.691 | 0.738 | |
Diarrhea incident event (9047/4606) | Logistic remove lost to follow-up | 0.674 | 0.659 | 0.705 |