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Table 5 AUROC results when predicting the outcomes within 3 years of the treatment for depression

From: An empirical analysis of dealing with patients who are lost to follow-up when developing prognostic models using a cohort design

Outcome (outcome count with partial time-at-risk/ outcome count with full time-at-risk) Solution Test Data 1: All patients with partial time-at-risk are removed (~ 47,000) Test Data 2: All patients with partial time-at-risk are included (~ 125,000) Test Data 3: All non-outcome patients with partial time-at-risk are removed
Acute liver injury incident event (107/43) Logistic remove lost to follow-up 0.755 (0.67–0.84) 0.786 (0.74–0.831) 0.82 (0.776–0.864)
Logistic keep lost to follow-up 0.767 (0.683–0.851) 0.811 (0.765–0.858) 0.836 (0.79–0.882)
Logistic remove non-outcomes lost to follow-up 0.701 (0.603–0.8) 0.713 (0.661–0.765) 0.852 (0.804–0.901)
Cox keep lost to follow-up 0.765 (0.681–0.849) 0.806 (0.759–0.853) 0.846 (0.802–0.89)
Ventricular arrhythmia and sudden cardiac death incident event (126/32) Logistic remove lost to follow-up 0.797 (0.721–0.874) 0.799 (0.762–0.837) 0.829 (0.792–0.865)
Logistic keep lost to follow-up 0.809 (0.721–0.897) 0.825 (0.787–0.862) 0.853 (0.816–0.891)
Logistic remove non-outcomes lost to follow-up 0.788 (0.706–0.871) 0.76 (0.72–0.801) 0.892 (0.859–0.925)
Cox keep lost to follow-up 0.816 (0.731–0.902) 0.826 (0.788–0.864) 0.866 (0.83–0.902)
Ischemic stroke—all inpatient, incident event (185/94) Logistic remove lost to follow-up 0.832 (0.793–0.871) 0.83 (0.805–0.854) 0.846 (0.822–0.87)
Logistic keep lost to follow-up 0.829 (0.791–0.866) 0.851 (0.829–0.874) 0.843 (0.819–0.866)
Logistic remove non-outcomes lost to follow-up 0.834 (0.798–0.87) 0.754 (0.727–0.781) 0.879 (0.857–0.902)
Cox keep lost to follow-up 0.837 (0.799–0.874) 0.843 (0.82–0.866) 0.862 (0.839–0.885)
Acute myocardial infarction incident event (273/111) Logistic remove lost to follow-up 0.8 (0.759–0.841) 0.804 (0.78–0.829) 0.838 (0.815–0.861)
Logistic keep lost to follow-up 0.809 (0.768–0.85) 0.83 (0.806–0.853) 0.845 (0.822–0.869)
Logistic remove non-outcomes lost to follow-up 0.794 (0.754–0.834) 0.75 (0.725–0.775) 0.889 (0.867–0.911)
Cox keep lost to follow-up 0.809 (0.768–0.849) 0.825 (0.801–0.849) 0.861 (0.838–0.883)
Delirium incident event (359/148) Logistic remove lost to follow-up 0.818 (0.786–0.85) 0.813 (0.793–0.833) 0.851 (0.833–0.87)
Logistic keep lost to follow-up 0.832 (0.801–0.863) 0.846 (0.828–0.864) 0.854 (0.836–0.873)
Logistic remove non-outcomes lost to follow-up 0.816 (0.784–0.847) 0.766 (0.745–0.787) 0.895 (0.879–0.912)
Cox keep lost to follow-up 0.831 (0.801–0.862) 0.842 (0.824–0.86) 0.873 (0.856–0.89)
Gastrointestinal hemhorrage incident event (430/210) Logistic remove lost to follow-up 0.754 (0.721–0.787) 0.737 (0.714–0.76) 0.79 (0.768–0.811)
Logistic keep lost to follow-up 0.765 (0.732–0.798) 0.767 (0.745–0.789) 0.784 (0.763–0.806)
Logistic remove non-outcomes lost to follow-up 0.749 (0.716–0.782) 0.651 (0.627–0.674) 0.84 (0.819–0.861)
Cox keep lost to follow-up 0.776 (0.745–0.808) 0.761 (0.739–0.783) 0.81 (0.789–0.831)
Decreased libido incident event (643/391) Logistic remove lost to follow-up 0.698 (0.674–0.722) 0.713 (0.695–0.732) 0.703 (0.684–0.722)
Logistic keep lost to follow-up 0.705 (0.682–0.729) 0.738 (0.72–0.755) 0.667 (0.646–0.687)
Logistic remove non-outcomes lost to follow-up 0.683 (0.659–0.708) 0.582 (0.563–0.601) 0.769 (0.751–0.788)
Cox keep lost to follow-up 0.708 (0.685–0.731) 0.73 (0.712–0.747) 0.705 (0.687–0.724)
Seizure incident event (712/313) Logistic remove lost to follow-up 0.783 (0.757–0.809) 0.767 (0.75–0.784) 0.805 (0.789–0.822)
Logistic keep lost to follow-up 0.779 (0.753–0.806) 0.787 (0.77–0.804) 0.788 (0.77–0.806)
Logistic remove non-outcomes lost to follow-up 0.753 (0.725–0.78) 0.674 (0.656–0.692) 0.849 (0.833–0.865)
Cox keep lost to follow-up 0.782 (0.756–0.808) 0.777 (0.76–0.794) 0.815 (0.798–0.832)
Alopecia incident event (1268/690) Logistic remove lost to follow-up 0.684 (0.666–0.702) 0.692 0.695
Logistic keep lost to follow-up 0.687 (0.669–0.706) 0.713 0.638
Logistic remove non-outcomes lost to follow-up 0.653 (0.633–0.672) 0.547 0.765
Cox keep lost to follow-up 0.691 (0.673–0.71) 0.704 0.698
Tinnitus incident event (1419/760) Logistic remove lost to follow-up 0.69 (0.671–0.709) 0.681 0.682
Logistic keep lost to follow-up 0.691 (0.672–0.71) 0.701 0.648
Logistic remove non-outcomes lost to follow-up 0.644 (0.624–0.663) 0.538 0.764
Cox keep lost to follow-up 0.695 (0.676–0.713) 0.689 0.702
Vertigo incident event (1663/911) Logistic remove lost to follow-up 0.696 (0.679–0.713) 0.699 0.698
Logistic keep lost to follow-up 0.697 (0.68–0.714) 0.727 0.665
Logistic remove non-outcomes lost to follow-up 0.672 (0.655–0.69) 0.568 0.781
Cox keep lost to follow-up 0.709 (0.693–0.726) 0.714 0.723
Fracture incident event (2222/1002) Logistic remove lost to follow-up 0.76 0.753 0.783
Logistic keep lost to follow-up 0.762 0.765 0.75
Logistic remove non-outcomes lost to follow-up 0.72 0.636 0.831
Cox keep lost to follow-up 0.764 0.755 0.792
Hyponatremia incident event (3032/1281) Logistic remove lost to follow-up 0.812 0.81 0.839
Logistic keep lost to follow-up 0.813 0.819 0.818
Logistic remove non-outcomes lost to follow-up 0.787 0.71 0.88
Cox keep lost to follow-up 0.812 0.812 0.846
Suicide and suicidal ideation incident event (3382/1549) Logistic remove lost to follow-up 0.822 0.829 0.849
Logistic keep lost to follow-up 0.821 0.839 0.827
Logistic remove non-outcomes lost to follow-up 0.807 0.702 0.882
Cox keep lost to follow-up 0.822 0.834 0.846
Hypothyroidism incident event (4119/2330) Logistic remove lost to follow-up 0.77 0.772 0.776
Logistic keep lost to follow-up 0.773 0.794 0.739
Logistic remove non-outcomes lost to follow-up 0.748 0.649 0.827
Cox keep lost to follow-up 0.773 0.777 0.781
Hypotension incident event (4385/1877) Logistic remove lost to follow-up 0.793 0.798 0.831
Logistic keep lost to follow-up 0.797 0.812 0.811
Logistic remove non-outcomes lost to follow-up 0.772 0.7 0.873
Cox keep lost to follow-up 0.798 0.803 0.841
Constipation incident event (7865/3934) Logistic remove lost to follow-up 0.69 0.684 0.727
Logistic keep lost to follow-up 0.688 0.708 0.673
Logistic remove non-outcomes lost to follow-up 0.663 0.569 0.791
Cox keep lost to follow-up 0.694 0.691 0.738
Diarrhea incident event (9047/4606) Logistic remove lost to follow-up 0.674 0.659 0.705
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