Table 1 Indications and Contraindications for rt-PA intravenous thrombolysis within 3 h
Type | No. | Eligibility Recommendations |
|---|---|---|
Indications | 1 | Symptoms of neurological impairment caused by ischemic stroke |
2 | Within 3 h of ischemic stroke symptom from onset or patient last known well or at baseline state. | |
3 | Patients older than 18 years | |
4 | Informed consent signed by patient or family member | |
Contraindications | 1 | Intracranial hemorrhage |
2 | With history of intracranial hemorrhage | |
3 | Stroke or severe head injury within 3 months | |
4 | Intracranial neoplasms or giant intracranial aneurysms | |
5 | Intracranial or intraspinal surgery within 3 months | |
6 | Received large surgery within 2 weeks | |
7 | Gastrointestinal bleed or urinary system hemorrhage within 3 weeks | |
8 | Associated with active visceral hemorrhage | |
9 | Associated with aortic arch dissection | |
10 | Arterial punctures with difficult to hemostasis in the past week | |
11 | Blood pressure > 180/100 mmHg | |
12 | Platelet count < 100* 109/L | |
13 | Treatment with low-molecular-weight heparin within 24 h | |
14 | international normalized ratio (INR) > 1.7 or Prothrombin time (PT) > 15 s | |
15 | Treatment with thrombin inhibitors or factor Xa inhibitors within 48 h, or abnormal laboratory examinations | |
16 | Blood glucose < 2.8 mmol/L or blood glucose > 22.22 mmol/L | |
17 | Large area of head infarction |