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Table 1 Five drugs against PD-1/PD-L1

From: Hybrid phenotype mining method for investigating off-target protein and underlying side effects of anti-tumor immunotherapy

Drug

Trademark

Owner

Drug target

Approval date

Pembrolizumab

Keytruda

MSD

PD-1

Sep 2014

Nivolumab

Opdivo

BMS

PD-1

Dec 2014

Atezolizumab

Tecentriq

Roche

PD-L1

May 2016

Avelumab

Bevancio

EMD and Pfizer

PD-L1

Mar 2017

Durmalumab

Imfinzi

Astra Zeneca

PD-L1

May 2017