Development and internal validation of prediction models for colorectal cancer survivors to estimate the 1-year risk of low health-related quality of life in multiple domains

Révész, Dóra; van Kuijk, Sander M. J.; Mols, Floortje; van Duijnhoven, Fränzel J. B.; Winkels, Renate M.; Hoofs, Huub; Kant, I Jmert; Smits, Luc J.; Breukink, Stéphanie O.; van de Poll-Franse, Lonneke V.; Kampman, Ellen; Beijer, Sandra; Weijenberg, Matty P.; Bours, Martijn J. L.

doi:10.1186/s12911-020-1064-9

BMC Medical Informatics and Decision Making

Table 3 Regression coefficients of the included predictors of the seven prediction models for health-related quality of life (HRQoL), after internal validation and shrinkage

From: Development and internal validation of prediction models for colorectal cancer survivors to estimate the 1-year risk of low health-related quality of life in multiple domains

	Global quality of life^c	Cognitive Functioning^c	Emotional Functioning^c	Physical Functioning^c	Role Functioning^c	Social Functioning^c	Fatigue^c
Intercept	−0.33	2.37	−0.62	1.20	−1.50	−0.71	−3.96
Included forced entry predictors^a
Age (years)	0.02	0.00	0.02	0.05	0.03	0.02	0.01
Sex (ref = male)	0.27	− 0.16	0.11	0.42	0.15	−0.02	0.20
Socio-economic status (ref = high)
Medium	0.22	0.13	0.14	−0.06	0.21	0.06	−0.11
Low	0.00	0.17	−0.03	−0.19	− 0.05	−0.20	− 0.42
Number of co-morbidities (ref = none)
1	−0.14	0.17	0.06	0.18	0.06	0.22	0.12
≥ 2	0.10	−0.10	0.23	0.49	0.32	0.47	0.29
Time since diagnosis (years)	0.02	−0.04	0.03	−0.01	− 0.03	−0.01	0.00
Stoma presence (ref = no)	−0.18	0.00	0.11	−0.02	0.40	0.28	−0.21
Body mass index (kg/m²)	0.02	−0.01	−0.05	0.01	−0.01	0.00	−0.01
Physical activity (ref = non-adherence)	−0.36	0.02	−0.06	−0.64	− 0.44	−0.25	− 0.45
Anxiety symptom score	0.02	−0.01	0.14	0.03	0.05	−0.01	0.04
Depressive symptom score	0.08	0.07	0.03	0.03	0.04	0.08	0.05
Baseline fatigue	0.01	0.01	0.01	0.01	0.01	0.01	0.05
Baseline HRQoL (specific per domain)	−0.05	−0.06	−0.04	−0.10	− 0.03	−0.04	–
Included predictors based on backwards selection^b
Chemotherapy (ref = no)	0.25					−0.35
Radiotherapy (ref = no)	0.27
Tumour stage (ref = stage I)
Stage II						−0.11
Stage III						0.52
Stage IV						0.50
Working status (ref = no)			0.48
Smoking (ref = no)	0.36		0.41	0.66		0.56	0.81
Social inhibition score			−0.03		0.02
Negative affectivity score		0.03	0.06			0.04
Micturition score		0.01
Chemotherapy side effects score	0.01		0.01			0.01	0.01
Stoma complaints score	0.01			0.02			0.02
Gastrointestinal complaints sum score						0.01	0.00
Pain score	0.01				0.01		0.01
Meat consumption adherence (ref = yes)			0.22

Footnotes:
^a Twelve candidate predictors were forced into each model, as there was strong evidence for their association with HRQoL in a systematic review [19]
^b Candidate predictors for which moderate or weak evidence was found, were selected with backwards selection procedures using Akaike’s Information Criterion (p < 0.1573). The following candidate predictors were not included in any of the models: tumor localization, marital status, fruit and vegetable consumption, alcohol consumption and waist circumference
^c Regression coefficients display the ln (odds) change in outcome, but no standard errors could be calculated after shrinkage; Formula for the probability of having low HRQoL = 1 / (1 + exp.[− Linear predictor]);
Linear predictor = intercept + sum of (predictor * regression coefficient)

Back to article page

ISSN: 1472-6947

Contact us

General enquiries: journalsubmissions@springernature.com