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Table 4 Top 10 OR results for 4-drug combination vs. 3-drug: with Bonferroni correction, a significant p is 5.27E-7

From: Mining and visualizing high-order directional drug interaction effects using the FAERS database

4-drug combination3-drug combinationORp-value
Acyclovir, Dexamethasone, Pamidronate, ZoledronateAcyclovir, Dexamethasone, Pamidronate126.359.82E-29
Dexamethasone, Lorazepam, Thalidomide, ZoledronateDexamethasone, Lorazepam, Thalidomide88.154.16E-22
Acetaminophen, Azithromycin, Cephalexin, LorazepamAzithromycin, Cephalexin, Lorazepam77.916.75E-19
Docetaxel, Fentanyl, Oxycodone, ZoledronateDocetaxel, Fentanyl, Oxycodone75.677.06E-20
Pamidronate, Sulfamethoxazole, Trimethoprim, ZoledronatePamidronate, Sulfamethoxazole, Trimethoprim70.292.35E-19
Docetaxel, Oxycodone, Prochlorperazine, ZoledronateDocetaxel, Oxycodone, Prochlorperazine62.642.99E-36
Acetaminophen, Dexamethasone, Oxycodone, TramadolDexamethasone, Oxycodone, Tramadol57.391.31E-14
Dexamethasone, Epoetin Alfa, Omeprazole, ZoledronateDexamethasone, Epoetin Alfa, Omeprazole56.201.37E-32
Acetaminophen, Alendronate, Omeprazole, OxycodoneAlendronate, Omeprazole, Oxycodone53.652.97E-15
Acetaminophen, Fentanyl, Fluconazole, OxycodoneFentanyl, Fluconazole, Oxycodone51.581.11E-14