Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women

Tsai, Kai-Leun; Chang, Che-Chang; Chang, Yu-Sheng; Lu, Yi-Ying; Tsai, I-Jung; Chen, Jin-Hua; Lin, Sheng-Hong; Tai, Chih-Chun; Lin, Yi-Fang; Chang, Hui-Wen; Lin, Ching-Yu; Su, Emily Chia-Yu

doi:10.1186/s12911-020-01380-y

BMC Medical Informatics and Decision Making

Table 3 Correlations between autoantibody isotypes against unmodified and 4-hydroxy-2-nonenal (HNE)-modified peptides and clinical variables in rheumatoid arthritis (RA) patients (n = 60)

From: Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women

	DAS28		RF		Anti-CCP		CRP		ESR		HNE adduct
	r	p value	r	p value	r	p value	r	p value	r	p value	r	p value
IgG anti-CFAH^1121−1230	0.1580	0.2279	0.0968	0.4696	0.0108	0.9347	0.0229	0.8659	0.2076	0.1115	− 0.009	0.9458
IgG anti-CFAH^1121−1230 HNE	− 0.0441	0.7379	− 0.0035	0.9794	− 0.0359	0.7852	− 0.1446	0.2831	0.1359	0.3006	− 0.0082	0.9501
IgM anti-CFAH^1121−1230	0.0424	0.7477	0.0626	0.6406	0.2100	0.1073	− 0.0164	0.9036	0.0756	0.5658	− 0.0503	0.7026
IgM anti-CFAH^1121−1230HNE	0.0377	0.7748	0.0435	0.746	0.2192	0.0924	− 0.0821	0.5435	0.1343	0.3063	0.0302	0.8186
IgG anti-HPT⁷⁸⁻¹⁰⁸	0.0929	0.4804	0.1386	0.2996	0.0659	0.6169	0.1138	0.3994	0.1695	0.1954	0.0754	0.5670
IgG anti-HPT⁷⁸⁻¹⁰⁸ HNE	− 0.0266	0.8400	0.0195	0.8848	0.2782	0.0314	0.1081	0.4236	0.1346	0.3052	− 0.0593	0.6529
IgM anti-HPT⁷⁸⁻¹⁰⁸	− 0.0171	0.8969	0.1711	0.1992	0.0877	0.5051	− 0.0591	0.6623	0.0074	0.9555	− 0.0453	0.7310
IgM anti-HPT⁷⁸⁻¹⁰⁸ HNE	0.2703	0.0367	0.6140	< 0.0001	0.0294	0.8238	0.1236	0.3596	0.2180	0.0943	0.1836	0.1603
IgG anti-IGKC²⁻¹⁹	− 0.3538	0.0056	− 0.1144	0.3926	− 0.0023	0.9862	− 0.1061	0.4320	− 0.123	0.3597	0.2097	0.1078
IgG anti-IGKC²⁻¹⁹ HNE	0.6023	− 0.3432	0.0073	− 0.1997	0.1328	0.1253	0.3399	− 0.0524	0.6986	− 0.0328	0.8035	0.0686
IgM anti-IGKC²⁻¹⁹	0.2816	0.0293	0.5674	< 0.0001	− 0.0588	0.6553	0.0511	0.7059	0.2692	0.0376	0.2667	0.0394
IgM anti-IGKC²⁻¹⁹ HNE	0.2487	0.0553	0.5404	< 0.0001	0.2439	0.0604	0.0429	0.7512	0.2985	0.0205	0.2709	0.0363
IgG anti-THRB^328−345	0.2703	0.0367	0.6140	< 0.0001	0.2439	0.0604	0.1236	0.3596	0.218	0.0943	0.1836	0.1603
IgG anti-THRB^328−345 HINE	0.1274	0.3320	0.3072	0.019	0.2549	0.0494	− 0.0575	0.6712	0.1341	0.307	0.0170	0.8972
IgM anti-THRB^328−345	− 0.0637	0.6290	0.2207	0.096	− 0.0365	0.7821	− 0.0292	0.8293	− 0.1513	0.2473	− 0.2796	0.0305
IgM anti-THRB^328−345 HNE	0.0818	0.5345	0.2845	0.0304	− 0.0438	0.7397	0.081	0.549	0.2597	0.0451	0.1036	0.4310

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