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Table 3 Correlations between autoantibody isotypes against unmodified and 4-hydroxy-2-nonenal (HNE)-modified peptides and clinical variables in rheumatoid arthritis (RA) patients (n = 60)

From: Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women

  DAS28 RF Anti-CCP CRP ESR HNE adduct
r p value r p value r p value r p value r p value r p value
IgG anti-CFAH1121−1230 0.1580 0.2279 0.0968 0.4696 0.0108 0.9347 0.0229 0.8659 0.2076 0.1115 − 0.009 0.9458
IgG anti-CFAH1121−1230 HNE − 0.0441 0.7379 − 0.0035 0.9794 − 0.0359 0.7852 − 0.1446 0.2831 0.1359 0.3006 − 0.0082 0.9501
IgM anti-CFAH1121−1230 0.0424 0.7477 0.0626 0.6406 0.2100 0.1073 − 0.0164 0.9036 0.0756 0.5658 − 0.0503 0.7026
IgM anti-CFAH1121−1230HNE 0.0377 0.7748 0.0435 0.746 0.2192 0.0924 − 0.0821 0.5435 0.1343 0.3063 0.0302 0.8186
IgG anti-HPT78−108 0.0929 0.4804 0.1386 0.2996 0.0659 0.6169 0.1138 0.3994 0.1695 0.1954 0.0754 0.5670
IgG anti-HPT78−108 HNE − 0.0266 0.8400 0.0195 0.8848 0.2782 0.0314 0.1081 0.4236 0.1346 0.3052 − 0.0593 0.6529
IgM anti-HPT78−108 − 0.0171 0.8969 0.1711 0.1992 0.0877 0.5051 − 0.0591 0.6623 0.0074 0.9555 − 0.0453 0.7310
IgM anti-HPT78−108 HNE 0.2703 0.0367 0.6140  < 0.0001 0.0294 0.8238 0.1236 0.3596 0.2180 0.0943 0.1836 0.1603
IgG anti-IGKC2−19 − 0.3538 0.0056 − 0.1144 0.3926 − 0.0023 0.9862 − 0.1061 0.4320 − 0.123 0.3597 0.2097 0.1078
IgG anti-IGKC2−19 HNE 0.6023 − 0.3432 0.0073 − 0.1997 0.1328 0.1253 0.3399 − 0.0524 0.6986 − 0.0328 0.8035 0.0686
IgM anti-IGKC2−19 0.2816 0.0293 0.5674  < 0.0001 − 0.0588 0.6553 0.0511 0.7059 0.2692 0.0376 0.2667 0.0394
IgM anti-IGKC2−19 HNE 0.2487 0.0553 0.5404  < 0.0001 0.2439 0.0604 0.0429 0.7512 0.2985 0.0205 0.2709 0.0363
IgG anti-THRB328−345 0.2703 0.0367 0.6140  < 0.0001 0.2439 0.0604 0.1236 0.3596 0.218 0.0943 0.1836 0.1603
IgG anti-THRB328−345 HINE 0.1274 0.3320 0.3072 0.019 0.2549 0.0494 − 0.0575 0.6712 0.1341 0.307 0.0170 0.8972
IgM anti-THRB328−345 − 0.0637 0.6290 0.2207 0.096 − 0.0365 0.7821 − 0.0292 0.8293 − 0.1513 0.2473 − 0.2796 0.0305
IgM anti-THRB328−345 HNE 0.0818 0.5345 0.2845 0.0304 − 0.0438 0.7397 0.081 0.549 0.2597 0.0451 0.1036 0.4310
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