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Table 1 Differential 4-hydroxy-2-nonenal (HNE)-modified peptide adducts in rheumatoid arthritis (RA) patients compared to healthy controls (HCs)

From: Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women

Proteina Modified peptideb Positionc Obs.d Calc.e dMf dMg Sequence foundwith modifications
HC RA
CFAH SHTLRTTCWDGKLEYPTCAK(+ 158) 1211–1230 858.439 858.435 0.0041 5.4 +
HRTGDEITYQCRNGFYPATRGNTAK(+ 138) 284–308 749.370 749.372 − 0.0018  −1.8 +
HPT AVGDKLPECEADDGC(+ 158)PKPPEIAHGYVEHSVR 78–108 869.925 869.927 − 0.0017  −1.3 +
ILGGHLDA(+ 156)K 162–170 540.329 540.327 0.0028 6.1 +
IGKC TVAA(+ 156)PSVFIFPPSDEQLK 2–19 701.384 701.386 − 0.0018  −1.7 +
TVA(+ 156)APSVFIFPPSDEQLK 2–19 1051.582 1051.575 0.0070 7.1 + +
VYACEVTHQ(+ 158)GLSSPVTKSFNR 83–103 862.780 862.785 − 0.0044  −4.5 +
THRB TFGSGEADCGLRPLFEK(+ 156)K 328–345 1056.036 1056.046 − 0.0107  −9.6 +
TFGSGEADC(+ 140)GLRPL(+ 156)FEK 328–344 708.376 708.375 0.0009 2.1 +
  1. aCFAH, Complement factor H; HPT, Haptoglobin; IGKC, Ig kappa chain C region; THRB, Prothrombin
  2. bSite of modified peptide
  3. cAmino acid positions of the first and the last residues in peptide
  4. dObs.: observed m/z of the modified peptides
  5. eCalc.: calculated m/z of the modified peptides
  6. fdM (Obs.-Calc.): mass accuracy
  7. gModified peptide mass accuracy (ppm)