CNFE-SE: a novel approach combining complex network-based feature engineering and stacked ensemble to predict the success of intrauterine insemination and ranking the features

Ranjbari, Sima; Khatibi, Toktam; Vosough Dizaji, Ahmad; Sajadi, Hesamoddin; Totonchi, Mehdi; Ghaffari, Firouzeh

doi:10.1186/s12911-020-01362-0

BMC Medical Informatics and Decision Making

Table 9 Summary statistics for the features of our dataset

From: CNFE-SE: a novel approach combining complex network-based feature engineering and stacked ensemble to predict the success of intrauterine insemination and ranking the features

Feature name	Min	First Q	Median	Third Q	Max	Mean	SD
Time diff between cycles	0	0	0	2	6.1	1.59	4.82
	0	0	0	1	6.9	1.25	3.83
Age_x	17	25	28	31	43	28.29	4.29
	16	26	29	32	47	28.97	4.68
Family demographic information (Education_x)	1	3	3	5	7	3.43	1.17
	1	3	3	5	7	3.4	1.22
Duration of marriage (years)	0.42	4	6	7	23	6	2.94
	0.25	4	6	7.5	26	6.31	3.19
Duration of infertility (Years)	0.25	2.5	4	5	15	4.36	2.62
	0.17	2.84	4.5	6	19	4.66	2.85
Menstrual HX (menarche old year)	9	13	13	14	27	13.35	1.46
	9	13	13	14	27	13.29	1.42
Current contraception duration	0	0	0	0	3	0.02	0.17
	0	0	0	0	8	0.01	0.19
Summary-Gravida	0	0	0	0	6	0.29	0.66
	0	0	0	0	6	0.26	0.61
Summary-para	0	0	0	0	3	0.08	0.31
	0	0	0	0	4	0.08	0.3
Abortion-early	0	0	0	0	4	0.17	0.48
	0	0	0	0	6	0.15	0.45
Abortion-late	0	0	0	0	3	0.02	0.16
	0	0	0	0	4	0.01	0.11
Summary-IUFD	0	0	0	0	2	0.01	0.11
	0	0	0	0	2	0	0.07
Summary-mole	0	0	0	0	1	0	0.06
	0	0	0	0	2	0	0.04
Summary-EP	0	0	0	0	1	0.01	0.11
	0	0	0	0	1	0.02	0.12
Summary-Preterm	0	0	0	0	3	0.03	0.2
	0	0	0	0	5	0.02	0.16
Summary-term	0	0	0	0	2	0.06	0.25
	0	0	0	0	4	0.06	0.26
Summary-living child	0	0	0	0	2	0.06	0.24
	0	0	0	0	4	0.06	0.25
IUI Hx-total	2	2	2	3	10	2.73	1.47
	2	2	2	3	11	2.7	1.4
Result-failed	0	0	0	0.41	6	0.39	0.78
	0	0	0	1	10	0.41	0.78
Result-pregnant	0	0	0	0	2	0.04	0.2
	0	0	0	0	2	0.02	0.14
Summary of ART cycle-IVF	0	0	0	0	2	0.01	0.13
	0	0	0	0	6	0.03	0.24
Summary of ART cycle-ZIFT	0	0	0	0	1	0	0.02
	0	0	0	0	3	0	0.06
Summary of ART cycle-E.T freeze	1	1	1	1	4	1.01	0.11
	1	1	1	1	5	1.01	0.1
Summary of ART cycle-Total	0	0	0	0	4	0.02	0.2
	0	0	0	0	9	0.04	0.31
Physical exam-height	142	158	161.05	165	187	161.61	5.74
	142	157	161.05	164	187	160.96	5.7
Physical exam-weight	40	61	67.31	74	170	68.14	12.54
	36	60	67	73	171	67.18	11.65
Physical exam-BMI	15.02	23.53	25.93	28.04	52.11	26.01	4.23
	14.19	23.34	25.93	28.01	57.09	25.92	4.22
IUI clinic-number of cycle	1	1	1	2	5	1.35	0.63
	1	1	1	2	7	1.31	0.59
Infertility medical treatment-Starting day of Stimulation (menstrual day)	1	3	3	3.42	8	3.39	0.73
	1	3	3	3.42	14	3.42	0.82
Letrosol dose (mg/day)	0	0	0	1.12	7.5	1.28	2.04
	0	0	0	1.12	7.5	1.1	1.9
Letrosol duration	0	0	0	1.19	12	1.34	2.17
	0	0	0	1.19	15	1.16	2.05
Letrosol start day of stimulation	0	0	0	0.77	5	0.86	1.41
	0	0	0	0.77	17	0.76	1.38
Clomiphen dose (mg/day)	0	0	59.87	100	150	57.97	45.82
	0	0	100	100	150	60.19	45.54
Clomiphen duration	0	0	3	5	12	2.94	2.33
	0	0	5	5	15	3.07	2.36
Clomiphen Start day of stimulation	0	0	2.08	3	6	2	1.66
	0	0	2.08	3	18	2.09	1.7
Summary of foliculogenesis-duration of stimulation	1	9	10.23	11	25	10.41	2.59
	1	9	10.23	11	31	10.2	2.63
Fostimon dose IU	0	0	0	77.03	337.5	91.4	23.39
	0	0	0	77.03	247.5	74.61	18.54
Gonal.F dose IU	0	0	0	0	3750	60.96	26.71
	0	0	0	0	6847	60.2	23.93
Menopour Dose IU	0	0	0	0	2700	10.65	125.74
	0	0	0	0	3300	9.74	104.92
HMG dose IU	0	0	0	150	2625	116.59	221.67
	0	0	0	150	3300	125.45	230.94
Merional dose IU	0	0	0	0	3900	66.25	295.78
	0	0	0	0	9075	44.76	202.57
Hemogon dose IU	0	0	0	0	1200	3.09	44.01
	0	0	0	0	3000	4.95	55.65
Menogan dose IU	0	0	0	0	3450	46.63	195.23
	0	0	0	0	3600	44.2	163.25
Bravelle dose IU	0	0	0	0	1050	7.93	57.94
	0	0	0	0	2100	9.55	77.96
Gonadotropin total dose	0	225	375	450	4500	453.57	502.6
	0	225	375	450	4424	411.52	410.99
Esteradiol dose	0	0	0	0	6	0.33	0.99
	0	0	0	0	8	0.42	1.16
Esteradiol duration	0	0	0	0	15	0.25	0.95
	0	0	0	0	14	0.3	0.96
No of dominate follicle at HCG day_17	0	1	1.65	2	10	1.81	1.46
	0	1	1.65	2	11	1.61	1.38
No of dominate follicle at HCG day_18	0	0	0.95	1	7	0.97	0.95
	0	0	0.94	1	9	0.92	0.87
HCG day endometrium (endometrial thickness)	4.3	8	8.51	9	19	8.67	1.47
	1	8	8.52	9	18	8.48	1.51
Age_y	20	30	33	35	72	32.82	4.7
	20	30	33	36	80	33.35	4.88
Family demographic information (Education_y)	1	2	3	4	7	3.38	1.23
	1	2	3	4	7	3.31	1.25
Specimen characteristics-abstinence	0.41	3	4	4.59	20	4.42	1.79
	0.41	3	4	4.59	20	4.43	1.89
Specimen characteristics-volume (normal range 2.7 mL)	0.1	2	3.2	4	9.5	3.29	1.56
	0.1	2	3	4	10.5	3.23	1.54
Specimen characteristics-PH	6	7.8	7.8	7.8	8.5	7.8	0.11
	6	7.8	7.8	7.8	85	7.8	0.10
Specimen characteristics liquefaction time (normal range15-30 min)	20	20	20	30	60	26.10	8.60
	15	20	20	25.53	60	25.34	8.48
Sperm concentration- total sperm count	10	104	170.1	202.72	399	165.46	84.57
	10	92.5	168	204	400	163.60	88.18
Sperm motility-total motility (normal range 50)	10	40	57.3	72.22	98.8	55.94	19.87
	10	37.6	55.9	72.22	100	54.51	21.10
Total motile sperm count	1.14	41.06	86.70	132.90	354.88	95.29	64.21
	1	35.52	81.55	132.90	370.11	93.71	69.08
Sperm motility-shaking grade	0	0	0	0	5	0.03	0.36
	0	0	0	0	15	0.03	0.48
Sperm motility-grade I-	0	0	0	0	19	0.12	1.14
	0	0	0	0	34.3	0.12	1.16
Sperm motility-grade I (grade d)	0	0	3.6	8.2	37.3	5.3	5.92
	0	0	3.6	8.2	46.4	5.40	6.18
Sperm motility Grade II-	0	0	0	0	50.3	0.27	3.04
	0	0	0	0	57.6	0.21	2.57
Sperm motility Grade II (grade c)	0	10.27	26.7	36.8	64.7	24.11	16.26
	0	11.9	26.4	36.7	70.0	24.25	15.97
Sperm motility Grade II +	0	0	0	0	23.2	0.01	0.58
	0	0	0	0	37.3	0	0.38
Sperm motility Grade III (a + b)	0	2.7	9.8	18.6	48.9	11.96	10.76
	0	3.3	9.8	17.8	49.8	11.96	10.82
Sperm morphology-normal morphology (normal range 30)	0	4	5.62	7	20	5.72	2.99
	0	4	5.62	7	28	5.6	3.1
Sperm morphology-abnormal morphology (normal range 70)	80	93	94.38	96	100	94.27	2.99
	72	93	94.38	96	133	94.4	3.13
Sperm morphology-amorph	0	69	76	80	92	68.59	22.61
	0	68.66	75	80	96	68.68	21.7
Sperm morphology-double head	0	0	0	1.02	8	0.85	1.20
	0	0	1	2	11	1.02	1.36
Sperm morphology-giant head	0	1	2	4	20	2.40	2.51
	0	1	2	4	25	2.53	2.61
Sperm morphology-pin head	0	1	2	4	30	2.95	3.47
	0	1	2	4	30	3.14	3.37
Sperm morphology-round head	0	1	2	4	20	2.85	2.92
	0	1	2	4	20	2.66	2.69
Sperm morphology-double tail	0	0	0	0	4	0.14	0.47
	0	0	0	0	10	0.19	0.63
Sperm morphology-coiled tail	0	1	3	5	25	3.79	3.48
	0	2	3	6	28	4.17	3.84
Sperm morphology-short tail	0	1	1	2.31	24	1.90	2.37
	0	1	1	3	28	2.20	2.75
Sperm morphology-cytoplasmic droplet	1	4	7	14	20	8.08	4.94
	1	4	7	12	30	8.12	4.85
Other tests-germinal cell	0	1	2	3	15	2.14	1.87
	0	1	2	3	21	2.20	1.79
Therapeutic duration of liquefaction (min)	5	15	16.13	16.13	145	16.16	5.70
	5	15	16.13	16.13	200	16.15	5.22
Therapeutic volume	0.5	2.5	3.59	4	13	3.6	1.64
	0.01	2.5	3.5	4	13	3.54	1.66
Therapeutic PH	5	7.76	7.8	7.8	7.9	7.77	0.09
	0.33	7.76	7.8	7.8	10	7.76	0.19
Before processing motility	0.04	0.3	0.37	0.45	0.92	0.38	0.14
	0.01	0.28	0.37	0.45	0.98	0.37	0.14
Before processing sperm concentration	4	45	54.62	68	110	55.57	18.7
	1	42	54.62	68	110	54.15	20.23
After processing motility	0.2	0.96	0.98	1	1	0.97	0.06
	0.02	0.96	0.98	1	1	0.96	0.09
Post wash total motile sperm count	1	127.4	209.88	264.87	460	213.81	27.49
	0.16	102.9	195	252	450	198.81	35.09
After processing sperm concentration	2	50	60.7	72	120	60.82	21.94
	1	42	60.7	72	120	57.23	24.87

^*Statistical description of numeric variables: Each row is divided into two parts in which the top row is related to the positive class and the bottom row represents the negative class

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