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Fig. 3 | BMC Medical Informatics and Decision Making

Fig. 3

From: Can statistical adjustment guided by causal inference improve the accuracy of effect estimation? A simulation and empirical research based on meta-analyses of case–control studies

Fig. 3

Mean square error of effect estimations under different adjustment strategies. Mean square error was presented according to different a ORAY, b ORUA, c ORUY, and d rUU in the target population; e number of cases and f matching approach in the original case–control studies; and g number of studies and h pooling method in the meta-analyses. The y-axis limits differ between plots. OR, odds ratio; A, exposure; Y, outcome; U, covariate. For all scenarios, pooled full-adjusted ORs showed the least mean square error. With insufficient or improper adjustment of covariates in original studies, the pooled effect estimations were away from the true value

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