Table 2 Clinical characteristics and outcomes by occurrence of hyperchloremia in days 1–7
Hyperchloremic | Non-hyperchloremic | All patients | ||
|---|---|---|---|---|
(n = 18181) | (n = 29893) | (n = 48074) | p value | |
Demographics | ||||
Age, median (IQR) | 66.9 (53.8–78.5) | 65.0 (52.4–77.4) | 65.7 (52.9–77.8) | < 0.001 |
Female, n (%) | 8324 (45.8) | 12684 (42.4) | 21008 (43.7) | < 0.001 |
Race, n (%) | ||||
Asian | 518 (2.8) | 603 (2.0) | 1121 (2.3) | < 0.001 |
Black | 1614 (8.9) | 3006 (10.1) | 4620 (9.6) | |
Hispanic | 598 (3.3) | 1053 (3.5) | 1651 (3.4) | |
White | 12930 (71.1) | 21477 (71.8) | 34407 (71.6) | |
Other (unreported) | 2521 (13.9) | 3754 (12.6) | 6275 (13.1) | |
Comorbid conditions, n (%) | ||||
Cancer | 1488 (8.2) | 3088 (10.3) | 4576 (9.5) | < 0.001 |
Cardiovascular | 9838 (54.1) | 16385 (54.8) | 26223 (54.5) | 0.137 |
Diabetes | 4625 (25.4) | 8436 (28.2) | 13061 (27.2) | < 0.001 |
Hepatic | 1989 (10.9) | 2960 (9.9) | 4949 (10.3) | < 0.001 |
Renal | 2589 (14.2) | 5279 (17.7) | 7868 (16.4) | < 0.001 |
Respiratory | 3434 (18.9) | 7263 (24.3) | 10697 (22.2) | < 0.001 |
Multiple comorbidities | 15304 (84.2) | 24819 (83.0) | 40123 (83.5) | 0.001 |
Outcome, n (%) | ||||
ICU mortality | 1855 (10.2) | 1703 (5.7) | 3558 (7.4) | < 0.001 |
New AKI by day 7 | 7788 (42.8) | 9445 (31.6) | 17233 (35.8) | < 0.001 |
MODS on day 7 | 1109 (6.1) | 781 (2.6) | 1890 (3.9) | < 0.001 |