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Table 2 Eligible online resource characteristics (n = 23)

From: Web-based online resources about adverse interactions or side effects associated with complementary and alternative medicine: a systematic review, summarization and quality assessment

Name of online resource Source eligible article(s) included in review Online resource URL Year established Availability for anyone to use? Type of developer CAM only or CAM/conventional therapies? How are CAM-specific adverse effects and side effects presented?
About Herbs Boddy et al. [25]; Molassiotis et al. [32]; Yap et al. [37] https://www.mskcc.org/cancer-care/diagnosis-treatment/symptom-management/integrative-medicine Unclear Yes, entirely free Researchers CAM only Drug summaries (Professional and consumer versions)
American Botanical Council Fitzpatrick [30]; Jackson et al. [10]; Kiefer et al. [12]; Motl et al. [11] https://abc.herbalgram.org/site/PageServer 1988 Yes, partially without subscription Council CAM only Monographs
Caremark Drug Interactions Yap et al. [37] https://cpref.goldstandard.com/inter.asp?r=8084 Unclear Yes, entirely free Company Both Drug interaction checker
Clinical Pharmacology (also known as Gold Standard) Gregory et al. [31] https://www.clinicalpharmacology.com/ Unclear Yes, but only with a subscription Company Both Drug interaction checker; monographs
Drug Information (formerly DrugDigest) Motl et al. [11] https://www.express-scripts.com/medco/consumer/ehealth/druginfo/dlmain.jsp?WC=N Unclear Yes, entirely free Company Both Drug summaries
Drug Product Database Motl et al. [11] https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html Unclear Yes, entirely free Government Both Monographs; safety update tables
Drugs.com Motl et al. [11]; Spanakis et al. [33]; Yap et al. [37] https://www.drugs.com/ 2001 Yes, entirely free Company Both Drug interaction checker; monographs (professional and consumer versions)
Electronic Medicines Compendium Motl et al. [11] https://www.medicines.org.uk/emc/ 1999 Yes, entirely free Company Both SmPC; patient leaflets; alert cards
Epocrates (plus or pro) Clauson et al. [27]; Fischer et al. [29]; Yap et al. [37] https://online.epocrates.com/ Unclear Yes, but only with a subscription Company Both Drug interaction checker; monographs
Herb-Drug Interactions, NCCIH Clinical Digest Allais et al. [8]; Boddy et al. [25]; Gregory et al. [31]; Jackson et al. [10]; Motl et al. [11] https://nccih.nih.gov/health/providers/digest/herb-drug 2015 Yes, entirely free Government CAM only Summaries provided in an herbal digest
Herbs at a Glance Boddy et al. [25]; Jackson et al. [10]; Gregory et al. [31]; Motl et al. [11] https://nccih.nih.gov/health/herbsataglance.htm Unclear Yes, entirely free Government CAM only Fact sheets
HIV drug interactions Motl et al. [11] https://www.hiv-druginteractions.org/checker 1999 Yes, entirely free Researchers Both Drug interaction checker; interaction charts
IBM Micromedex (includes DrugDex, Drug-Reax, AltMedDex) Clauson et al. [27]; Fischer et al. [29]; Jackson [9]; Jackson et al. [10]; Kiefer [12]; Meyer et al. [13]; Walker [36]; Yap et al. [37] https://www.micromedexsolutions.com/home/dispatch/ssl/true Mid-1970s Yes, but only with a subscription Company Both Drug interaction checker; monographs; patient fact sheets
Lexi-Natural (includes LexiComp) Clauson et al. [27]; Gregory et al. [31]; Fischer et al. [29]; Motl et al. [11]; Yap et al. [37] https://webstore.lexi.com/Store/Individual-Databases/Lexi-Natural-Products Unclear Yes, but only with a subscription Company Both Monographs; patient handouts
MedicinesComplete (includes Herbal Medicines; formerly known as the British National Formulary) Jackson [9]; Jackson et al. [10]; Yap et al. [37] https://about.medicinescomplete.com/publication/herbal-medicines/ Unclear Yes, but only with a subscription Company Both Monographs
Medscape Motl et al. [11]; Spanakis et al. [33] https://www.medscape.com/ 1995 Yes, entirely free Company Both Drug interaction checker; monographs
Merck Manual Motl et al. [11] https://www.merckmanuals.com/en-ca/ 1999 Yes, entirely free Company Both Drug interaction checker; monographs (professional and consumer versions)
National Cancer Institute Boddy et al. [25] https://www.cancer.gov/about-cancer/treatment/cam Unclear Yes, entirely free Government CAM only Drug summaries (professional and consumer versions)
Natural Medicines (formerly Natural Medicine Comprehensive Database (NMCD) and Natural Standard Database (NSD)) (online and mobile app) Archer et al. [24]; Boddy et al. [25]; Boehmer et al. [26]; Clauson et al. [27]; Faubert et al. [28]; Fischer et al. [29]; Fitzpatrick [30]; Gregory et al. [31]; Jackson et al. [10]; Kiefer et al. [12]; Motl et al. [11]; Sun et al. [34]; Sweet et al. [14]; Tomasulo [35]; Walker [36]; Yap et al. [37] https://naturalmedicines.therapeuticresearch.com/ Early 2000s Yes, but only with a subscription Company CAM only Drug interaction checker; monographs; patient handouts
OncoRx Database (called Onco-Rx as a website, and OncoRx-MI as a mobile app) Yap et al. [37] https://www.onco-informatics.com/oncorx/ 2007 (website), unclear (mobile app) Yes, but only with a subscription Researchers Both Drug interaction checker
PEPID Drug Information Database Clauson et al. [27]; Fischer et al. [29] https://www.pepid.com/ Unclear Yes, but only with a subscription Company Both Drug interaction checker; patient education handouts; monographs
RxList (owned by WebMD) Motl et al. [11]; Spanakis et al. [33] https://www.rxlist.com/script/main/hp.asp 1995 Yes, entirely free Company Both Monographs
RxMed Motl et al. [11] https://www.rxmed.com 1994 Yes, entirely free Company Both Monographs
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