Table 2 The detection of lipid species as potential biomarkers for diagnosis of prostate cancer
From: Identification of plasma lipid species as promising diagnostic markers for prostate cancer
Group | Lipid species | P value | Fold-change | Sensitivity | Specificity | PPV | NPV | ROC Area |
|---|---|---|---|---|---|---|---|---|
Cancer vs. BPH | LPE (20:0) | 0.034 | − 1.81 | 80.0% | 44.7% | 53.3% | 73.9% | 0.543 |
PA (38:3) | 0.018 | −2.34 | 73.3% | 55.3% | 56.4% | 72.4% | 0.643 | |
PS (34:2) | 0.009 | −2.26 | 80.0% | 57.9% | 60% | 78.6% | 0.689 | |
PC (44:5) | 0.014 | −2.21 | 83.3% | 50.0% | 56.8% | 79.2% | 0.624 | |
PC (44:2) | 0.004 | −1.79 | 43.3% | 89.5% | 76.5% | 66.7% | 0.686 | |
Combination of 5 lipids | – | – | 73.3% | 81.6% | 75.9% | 79.5% | 0.800 | |
Cancer vs. Control | PE (32:2) | 0.009 | 2.29 | 43.3% | 84.8% | 65% | 69.6% | 0.653 |
PA (36:3) | 0.007 | −3.60 | 86.7% | 47.8% | 52% | 84.6% | 0.672 | |
PS (34:2) | 0.002 | 2.91 | 80% | 60.9% | 57.1% | 82.4% | 0.704 | |
PE (40:3) | 0.042 | −1.43 | 23.3% | 89.1% | 58.3% | 64.1% | 0.628 | |
PC (44:2) | 0.017 | −1.72 | 40% | 87% | 66.7% | 69.0% | 0.661 | |
Combination of 5 lipids | – | – | 76.7% | 80.4% | 71.9% | 84.1% | 0.836 | |
Cancer vs. Non-cancer | PA (36:3) | 0.011 | −3.45 | 76.7% | 44% | 32.9% | 84.1% | 0.646 |
PS (34:2) | 0.001 | −2.62 | 76.7% | 59.5% | 40.4% | 87.7% | 0.633 | |
PE (32:2) | 0.010 | 2.04 | 30% | 92.9% | 60% | 78.8% | 0.614 | |
LPE (20:0) | 0.021 | −1.79 | 70.0% | 41.7% | 30.0% | 79.5% | 0.578 | |
PC (44:5) | 0.021 | −2.19 | 86.7% | 39.3% | 33.8% | 89.2% | 0.613 | |
PC (44:2) | 0.001 | −1.75 | 3.3% | 94% | 16.7% | 78.8% | 0.661 | |
|  | Combination of 6 lipids | – | – | 73.3% | 82.1% | 59.5% | 89.6% | 0.837 |