Towards more efficient use of intravenous lumens in multi-infusion settings: development and evaluation of a multiplex infusion scheduling algorithm

Table 1 Drug multiplexing parameters

Drug name	Multiplexing allowed	BT_1/2 (min)	Maximal interruption time (min)^a	Maximal administration rate (mg/min unless otherwise specified)^b	ICU Concentration (mg/ml unless otherwise specified)
amiodarone	yes	60	15^c	100	12
amoxicilin	yes	75	17	250	20
ceftazidime	yes	180	45	500	42
clindamycin	yes	180	45	30	38
clonidine	yes	40	20	15 μg/min	10 μg/ml
dexmedetomidine	yes	120	15	6 μg/min	8 μg/ml
dobutamine	no	2	0	N/A	5
dopamine	no	2	0	N/A	4
epinephrine/ adrenalin	no	2	0	N/A	0.1
esomeprazole	yes	120	100	4	1.6
fentanyl	yes	20	10	25 μg/min	0.05
phenylephrine	no	4	1	15 μg/min	0.1
flucloxacillin	yes	120	30	500	50
furosemide	yes	60	30	20	5.0
gentamycin	yes	120	15	33	1
heparin	yes	15	30	1500 IU/min	400 IU/ml
hydrocortisone	yes	180	90	50	4
insulin	t.b.d.^d	15	15	0.8 IU/min	1 IU/ml
potassium chloride	yes	60	30	0.3 mmol/min	1 mmol/ml
s-ketamine	yes	10	5	5	5
methylprednisolone	yes	120	90	30	60
magnesium sulfate	yes	60	60	200 mg/min	100 mg/ml
midazolam	yes	15	25	2	2
milrinone	yes	140	30	0.3	0.2
morphine	yes	20	15	4	1
nicardipine	yes	30	30	0.5	1.0
nitroglycerin	no	15	7	0.5	0.5
norepinephrine/ noradrenalin	no	2	0	N/A	0.1
paracetamol	yes	120	60	60	10
propofol	yes	15	4	200	20
sufentanil	yes	30	30	25 μg/min	10 μg/ml
tacrolimus	yes	240	60	7 μg/min	40 μg/ml
tobramycin	yes	120	15	8	6
vancomycin	yes	120	60	10	40

ICU intensive care unit, min minutes, BT_1/2 biological half-life, IU/ml International units per milliliter, N/A not applicable, since interruption is not allowed
^aAssessed by clinical experts from our local intensive care unit and hospital pharmacy
^bAssuming a body weight of > 60 kg
^cAmiodarone’s maximal interruption time may become longer after multiple days of therapy
^dTo be determined. Insulin is known to adsorb to the tubing wall, future study is required to determine suitability for drug multiplexing

ISSN: 1472-6947