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Table 2 Rankings of individual SNPs in the WHI Clinical Trial and Observational Study SHARe among African American women in the WHI (n=6704). Results from the following analyses are reported: (1) The proposed BVS approach (BVSe); (2) BVS assuming perfect tests (BVSperfect); (3) univariate (SNP by SNP) analysis assuming a Cox PH model; and (4) univariate analysis adjusting for error in self-report (icensmis). Each analysis simultaneously adjusted for the top two principal components to account for population stratification. SNPs are ordered from most (rank= 1) to least important (rank >1000) with regard to their association with time to incident type 2 diabetes. Ranks >1000 are denoted by −

From: Bayesian variable selection for high dimensional predictors and self-reported outcomes

BVSe

BVSperfect

Cox PH

icensmis

rs

Intron

Upstream

Downstream

Rank

Rank

Rank

Rank

Number

   

1

2

1

1

rs2805434

RYR2

  

2

-

15

10

rs5946729

  

SHOX, CRLF2

3

-

28

20

rs10126793

 

PDK3

SUPT20HL1

4

-

3

3

rs10054129

 

RXFP3, ADAMTS12

 

5

-

22

16

rs7523871

 

RNU5F-1

LOC101929689, LYPLAL1

6

-

-

-

rs6795523

IGSF11

  

7

-

-

-

rs149091

 

ANKRD55

LOC102467147

8

-

81

69

rs10820848

 

LOC101927847

UNQ6494

9

-

-

-

rs10950835

 

SP4

RPL23P8

10

-

-

-

rs2714365

 

CHST9

CDH2

34

-

9

9

rs17693218

 

LYZL1

C10orf126

-

-

2

2

rs2805429

RYR2

  

-

-

5

5

rs7737188

 

RXFP3, ADAMTS12

 

-

-

8

7

rs16917265

 

INIP, SNX30

 

-

-

6

6

rs4144636

ASTN2

  

-

-

7

8

rs12247963

FAM188A

  

-

-

4

4

rs15958

   

-

-

10

17

rs1959083

  

LINC00520, RPL13AP3

-

1

13

19

rs6573059

  

LINC00520, RPL13AP3