Skip to main content

Table 5 Performance characteristics of the risk model in the external validation when using different cut-off values

From: Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice

Performance characteristics

Cut-off-value ≥ 5

Cut-off value ≥ 6

Cut-off value ≥ 7

> 450/470 ms

> 500 ms

> 450/470 ms

> 500 ms

> 450/470 ms

> 500 ms

Sensitivity (%)

86.3

91.0

76.6

83.9

63.8

69.0

Specificity (%)

16.3

15.9

28.5

27.5

40.4

39.5

False Omission Rate (%)

37.3

5.8

36.8

6.0

38.9

7.9

Accuracy (%)

0.45

0.23

0.48

0.33

0.50

0.42

Youden’s index (%)

2.6

6.9

5.1

11.3

4.2

8.5