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Table 3 Risk scores assigned to potential risk factors based on their Log OR

From: Development and validation of a tool to assess the risk of QT drug-drug interactions in clinical practice

 

Bazett formula

Fridericia formula

Predictors

Log OR

Score

OR (95% CI)

Log OR

Score

OR (95% CI)

Age (in years)

  ≤ 25

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 26–50

− 0.15

0

0.71 (0.07–7.79)

–

–

–

 51–75

0.20

1

1.58 (0.17–15.19)

–

–

–

  ≥ 76

0.51

2

3.20 (0.25–41.21)

–

–

–

Arrhythmia

0.55

2

3.52 (1.03–12.07)

–

–

–

Hypertension

0.54

2

3.44 (1.36–8.68)

0.77

2

5.92 (1.92–28.27)

Loop diuretics

–

–

–

0.56

2

3.65 (1.18–11.24)

  1. Abbreviations: Ref, reference value; OR, odds ratio; 95% CI, 95% confidence interval