| Methods | Description | Signal score computation |
---|---|---|---|
Frequentist statistical methods | Proportional Reporting Ratio (PRR) | Statistical method to calculate the relative risk in order to measure the association strength for a drug-ADR pair | PRR05: lower bound of the 95% confidence interval of relative risk reporting ratio distribution |
 | Reporting Odds Ratio (ROR) | Statistical method to calculate the odds ratio in order to measure the association strength for a drug-ADR pair | ROR05: lower bound of the 95% confidence interval of odds ratio distribution |
Bayesian-based methods | Multi-item Gamma Poisson Shrinker (MGPS) | Bayesian-based method to prevent false-positive signals from multiple comparisons. Generate an adjusted value based on Reporting Ratio (RR) | EB05: lower bound of the 95% of the posterior distribution for RR |
 | Bayesian Confidence Propagation Neural Network (BCPNN) | Bayesian-based method to prevent false-positive signals from multiple comparisons. Generate an adjusted value based on Information Component (IC) | BCPNN25: lower bound of the 2.5% of the posterior distribution for IC |