Skip to main content

Table 1 Common disproportionality analysis for safety signals

From: Towards early detection of adverse drug reactions: combining pre-clinical drug structures and post-market safety reports

 

Methods

Description

Signal score computation

Frequentist statistical methods

Proportional Reporting Ratio (PRR)

Statistical method to calculate the relative risk in order to measure the association strength for a drug-ADR pair

PRR05: lower bound of the 95% confidence interval of relative risk reporting ratio distribution

 

Reporting Odds Ratio (ROR)

Statistical method to calculate the odds ratio in order to measure the association strength for a drug-ADR pair

ROR05: lower bound of the 95% confidence interval of odds ratio distribution

Bayesian-based methods

Multi-item Gamma Poisson Shrinker (MGPS)

Bayesian-based method to prevent false-positive signals from multiple comparisons. Generate an adjusted value based on Reporting Ratio (RR)

EB05: lower bound of the 95% of the posterior distribution for RR

 

Bayesian Confidence Propagation Neural Network (BCPNN)

Bayesian-based method to prevent false-positive signals from multiple comparisons. Generate an adjusted value based on Information Component (IC)

BCPNN25: lower bound of the 2.5% of the posterior distribution for IC