Fig. 1

The complex evolution of anticancer treatment evidence and approvals. Adapted from the PACE CII online tool at http://scoringprogress.com. The x-axis shows time since the first approval; the y-axis shows the E-score, a measure of strength of evidence that the approved treatment increases overall survival. Vertical lines indicate the year during which the treatment was first approved for the respective cancer. Year 0 indicates the first approval of this treatment for any cancer