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Fig. 2 | BMC Medical Informatics and Decision Making

Fig. 2

From: Expression alteration of microRNAs in Nucleus Accumbens is associated with chronic stress and antidepressant treatment in rats

Fig. 2

differential expressing analysis and downstream pathway/network analysis. a Tendency of miRNA alteration.x-axis:log2(fold change) in case vs. control; y-axis:log2(fold change) in treat vs. case. Colored dots represent miRNAs that reach criteria of significant differential expression (FDR < 0.05, absolute log2FC > 1). b top GO-BP and KEGG pathways for case vs. control DE-miRNA targets. c top GO-BP and KEGG pathways for treat vs. case DE-miRNA targets. d Network analysis for case vs. control DE-miRNA. d Network analysis for treat vs. case DE-miRNA. For (d, e), triangles represent miRNAs and circles represent transcription products of genes. A straight line means that the mRNA is predicted to be regulated by the miRNA, and the color of the line represents the context score of this prediction (see method). Red lines represent a lower score, which means the prediction is highly credible

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BMC Medical Informatics and Decision Making

ISSN: 1472-6947

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