ThalPred: a web-based prediction tool for discriminating thalassemia trait and iron deficiency anemia

Table 3 Performance comparisons of existing discriminant formulas and indices proposed for differentiation of iron deficiency anemia from thalassemia trait

Indices/ formulas	Cut-off	Ac (%)	Sn (%)	Sp (%)	MCC	YI	AUC
BI = RDW	15	36.02	19.18	97.50	0.19	0.17	0.71
EF = MCV – 10 × RBC	15	52.15	45.89	75.00	0.17	0.21	0.70
E&F = MCV - RBC – 5Hb - 6.4	0	67.42	60.95	92.50	0.44	0.54	0.91
G&K = MCV²×RDW/100Hb	72	84.95	82.88	92.50	0.66	0.75	0.93
MI = MCV/RBC	13	54.30	47.95	77.50	0.21	0.25	0.75
RDWI = MCV ×RDW/RBC	220	67.20	60.96	90.00	0.42	0.51	0.92
RI = RDW/RBC	3.3	87.63	86.30	92.50	0.70	0.79	0.98
S&L = MCV²×MCH/100	1530	74.19	92.47	7.50	−0.01	0.00	0.31
SI = MCV – RBC - 3Hb	27	53.76	45.21	85.00	0.26	0.302	0.80
SF = MCH/RBC	3.8	37.63	26.71	77.50	0.04	0.04	0.68
SiF = 1.5Hb – 0.05MCV	14	24.73	31.51	0.00	−0.56	−0.69	0.02
KF1 = RBC/Hct + 0.5RDW	8.2	70.97	64.38	95.00	0.49	0.59	0.93
KF2 = 5RDW/RBC	16.8	89.79	89.04	92.50	0.74	0.82	0.98

Ac Accuracy; AUC Area under receiver operating curve; Hb Hemoglobin; Hct Hematocrit; IDA Iron deficiency anemia; MCC Matthew’s correlation coefficient; MCH mean corpuscular hemoglobin; MCV mean corpuscular volume; RBC red blood cell count; RDW red blood cell distribution width; Sn Sensitivity; Sp Specificity; TT Thalassemia trait; YI Youden’s index

ISSN: 1472-6947