Table 1 Gene-variants tested by OmniSeq Comprehensive®

Single Nucleotide Variants (SNVs), Insertions, Deletions, and Indels

Hotspot: ABL1, AKT1, ALK, AR, ARAF, BRAF, BTK, CBL, CDK4, CHEK2, CSF1R, CTNNB1, DDR2, DNMT3A, EGFR, ERBB2, ERBB3, ERBB4, ESR1, EZH2, FGFR1, FGFR2, FGFR3, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, IFITM1, IFITM3, JAK1, JAK2, JAK3, KDR, KIT, KNSTRN, KRAS, MAGOH, MAP2K1, MAP2K2, MAPK1, MAX, MED12, MET, MLH1, MPL, MTOR, MYD88, NFE2L2, NPM1, NRAS, PAX5, PDGFRA, PIK3CA, PPP2R1A, PTPN11, RAC1, RAF1, RET, RHEB, RHOA, SF3B1, SMO, SPOP, SRC, STAT3, U2AF1, XPO1

DNA-Seq

Full Coding: APC, ATM, BAP1, BRCA1, BRCA2, CDH1, CDKN2A, FBXW7, GATA3, MSH2, NF1, NF2, NOTCH1, PIK3R1, PTCH1, PTEN, RB1, SMAD4, SMARCB1, STK11, TET2, TP53, TSC1, TSC2, VHL, WT1

Copy Number Gain

ACVRL1, AKT1, APEX1, AR, ATP11B, BCL2L1, BCL9, BIRC2, BIRC3, CCND1, CCNE1, CD274, CD44, CDK4, CDK6, CSNK2A1, DCUN1D1, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GAS6, IGF1R

Copy Number Loss

APC, ATM, BAP1, BRCA1, BRCA2, CDH1, CDKN2A, FBXW7, GATA3, MSH2, NF1, NF2, NOTCH1, PIK3R1, PTCH1, PTEN, RB1, SMAD4, SMARCB1, STK11, TET2, TP53, TSC1, TSC2, VHL, WT1

Fusions

ABL1, AKT3, ALK, AXL, BRAF, EGFR, ERBB2, ERG, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, MET, NTRK1, NTRK2, NTRK3, PDGFRA, PPARG, RAF1, RET, ROS1

RNA-Seq