Modelling cancer outcomes of bone metastatic patients: combining survival data with N-Telopeptide of type I collagen (NTX) dynamics through joint models

Table 5 Coefficients and p-values of the JM

	#	Age diagnosis		Sex		ExtraMets		log(NTX)
		Value	p-value	Value	p-value	Value	p-value	Value	p-value
Omit	1	0.0185	0.0152	0.3160	0.1499	0.6655	0.0035	0.2093	0.0593
	2	0.0184	0.0160	0.3134	0.1530	0.6649	0.0035	0.2175	0.0638
	3	0.0184	0.0147	0.2655	0.2216	0.6051	0.0085	0.1095	0.0442
LOCF	4	0.0186	0.0144	0.3006	0.1672	0.6687	0.0032	0.1674	0.0755
	5	0.0186	0.0147	0.3005	0.1672	0.6673	0.0032	0.1692	0.0753
	6	0.0175	0.0242	0.2930	0.1820	0.6322	0.0053	0.1353	0.0289
OCS	7	0.0182	0.0164	0.3048	0.1612	0.6586	0.0036	0.1955	0.0430
	8	0.0181	0.0166	0.3046	0.1615	0.6575	0.0037	0.1962	0.0430
	9	0.0170	0.0233	0.3153	0.1496	0.6681	0.0032	0.1966	0.0013

In models 1 to 3 the missing values were omitted, in 4 to 6 LOCF was used to impute the missing values and in 7 to 9 OCS was used

ISSN: 1472-6947