Fig. 1

Revisitation of precision medicine. a Precision medicine moves from a genetics-centered personalization of treatment on to a dynamic risk assessment and optimization of current and future health status through immutable (e.g. genetics) and actionable factors (e.g. behavior). b Disease phenotypes are reclassified on the basis of new system-level evidence, identifying pathophysiological endotypes associated with common, known phenotypes. The logos are trademarks of their respective companies and institutions, and their uses do not represent affiliation or endorsement