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Table 7 Results obtained with the entire set of features, the FS ensemble and the individual FS algorithms for time-windows of a) 2-years, b) 3-years and c) 4-years, using CCC data. Results are averaged over the 10 × 5 stratified cross validation with subset size defined by the optimized RPT threshold (β = 10)

From: Neuropsychological predictors of conversion from mild cognitive impairment to Alzheimer’s disease: a feature selection ensemble combining stability and predictability

  

Ensemble

ReliefF

MIM

CMIM

MRMR

Chi-Squared

LL21

All features

2-years windows

AUC

0.821 ± 0.00

0.813 ± 0.01

0.806 ± 0.01

0.817 ± 0.01

0.827 ± 0.01

0.820 ± 0.01

0.809 ± 0.01

0.814 ± 0.01

Sensitivity

0.738 ± 0.02

0.744 ± 0.03

0.743 ± 0.02

0.735 ± 0.03

0.757 ± 0.02

0.742 ± 0.02

0.750 ± 0.02

0.385 ± 0.04

Specificity

0.765 ± 0.01

0.758 ± 0.01

0.762 ± 0.01

0.767 ± 0.01

0.764 ± 0.01

0.763 ± 0.01

0.746 ± 0.01

0.920 ± 0.01

Stability

0.936 ± 0.01

0.889 ± 0.03

0.928 ± 0.03

0.872 ± 0.03

0.975 ± 0.02

0.894 ± 0.02

0.986 ± 0.02

# Features

20

14

16

25

16

20

12

40

3-years windows

AUC

0.859 ± 0.00

0.860 ± 0.00

0.861 ± 0.00

0.853 ± 0.04

0.855 ± 0.00

0.861 ± 0.00

0.863 ± 0.00

0.853 ± 0.00

Sensitivity

0.778 ± 0.01

0.779 ± 0.01

0.778 ± 0.01

0.778 ± 0.01

0.762 ± 0.01

0.776 ± 0.01

0.775 ± 0.01

0.734 ± 0.01

Specificity

0.781 ± 0.01

0.778 ± 0.01

0.784 ± 0.01

0.779 ± 0.01

0.785 ± 0.01

0.786 ± 0.00

0.792 ± 0.00

0.819 ± 0.00

Stability

0.950 ± 0.02

0.922 ± 0.03

0.939 ± 0.01

0.885 ± 0.03

0.767 ± 0.03

0.992 ± 0.02

0.996 ± 0.02

# Features

20

18

18

19

35

20

18

40

4-years windows

AUC

0.868 ± 0.00

0.868 ± 0.00

0.868 ± 0.00

0.865 ± 0.00

0.850 ± 0.00

0.869 ± 0.00

0.865 ± 0.00

0.859 ± 0.00

Sensitivity

0.793 ± 0.01

0.773 ± 0.01

0.774 ± 0.01

0.795 ± 0.01

0.785 ± 0.01

0.793 ± 0.01

0.789 ± 0.01

0.729 ± 0.01

Specificity

0.788 ± 0.00

0.792 ± 0.01

0.791 ± 0.00

0.789 ± 0.01

0.782 ± 0.01

0.789 ± 0.00

0.789 ± 0.00

0.841 ± 0.01

Stability

0.955 ± 0.02

0.908 ± 0.02

0.951 ± 0.01

0.862 ± 0.3

0.802 ± 0.03

0.923 ± 0.02

0.909 ± 0.02

# Features

19

18

16

18

12

16

15

40