Table 6 Results obtained with the entire set of features, the FS ensemble and the individual FS algorithms for time-windows of a) 2-years, b) 3-years and c) 4-years, using ADNI data. Results are averaged over the 10 × 5 stratified cross validation with subset size defined by the optimized RPT threshold (β = 10)
Ensemble | ReliefF | MIM | CMIM | MRMR | Chi-Squared | LL21 | All features | ||
|---|---|---|---|---|---|---|---|---|---|
2-years windows | AUC | 0.882 ± 0.01 | 0.861 ± 0.01 | 0.865 ± 0.01 | 0.882 ± 0.01 | 0.859 ± 0.01 | 0.864 ± 0.0 | 0.851 ± 0.01 | 0.860 ± 0.01 |
Sensitivity | 0.727 ± 0.02 | 0.758 ± 0.02 | 0.754 ± 0.03 | 0.736 ± 0.03 | 0.749 ± 0.02 | 0.771 ± 0.01 | 0.752 ± 0.01 | 0.594 ± 0.02 | |
Specificity | 0.848 ± 0.01 | 0.826 ± 0.01 | 0.833 ± 0.02 | 0.847 ± 0.01 | 0.803 ± 0.00 | 0.815 ± 0.01 | 0.821 ± 0.01 | 0.903 ± 0.01 | |
Stability | 0.913 ± 0.02 | 0.888 ± 0.02 | 0.907 ± 0.02 | 0.892 ± 0.02 | 1.0 ± 0.0 | 1.0 ± 0.0 | 0.837 ± 0.02 | – | |
# Features | 32 | 8 | 25 | 32 | 7 | 4 | 11 | 79 | |
3-years windows | AUC | 0.872 ± 0.004 | 0.857 ± 0.00 | 0.871 ± 0.00 | 0.872 ± 0.00 | 0.863 ± 0.00 | 0.859 ± 0.01 | 0.868 ± 0.00 | 0.835 ± 0.01 |
Sensitivity | 0.775 ± 0.018 | 0.784 ± 0.01 | 0.778 ± 0.01 | 0.782 ± 0.02 | 0.728 ± 0.01 | 0.776 ± 0.02 | 0.793 ± 0.02 | 0.714 ± 0.02 | |
Specificity | 0.829 ± 0.011 | 0.817 ± 0.01 | 0.831 ± 0.01 | 0.827 ± 0.00 | 0.805 ± 0.01 | 0.841 ± 0.01 | 0.804 ± 0.01 | 0.782 ± 0.01 | |
Stability | 0.889 ± 0.013 | 0.892 ± 0.02 | 0.913 ± 0.02 | 0.941 ± 0.01 | 0.789 ± 0.02 | 0.986 ± 0.02 | 0.944 ± 0.03 | – | |
# Features | 30 | 15 | 23 | 29 | 70 | 10 | 45 | 79 | |
4-years windows | AUC | 0.886 ± 0.003 | 0.876 ± 0.00 | 0.881 ± 0.00 | 0.883 ± 0.01 | 0.867 ± 0.01 | 0.870 ± 0.01 | 0.872 ± 0.01 | 0.853 ± 0.006 |
Sensitivity | 0.789 ± 0.007 | 0.788 ± 0.01 | 0.799 ± 0.01 | 0.798 ± 0.01 | 0.732 ± 0.01 | 0.761 ± 0.01 | 0.792 ± 0.02 | 0.705 ± 0.009 | |
Specificity | 0.819 ± 0.013 | 0.817 ± 0.02 | 0.818 ± 0.01 | 0.831 ± 0.01 | 0.815 ± 0.01 | 0.837 ± 0.01 | 0.819 ± 0.01 | 0.831 ± 0.017 | |
Stability | 0.895 ± 0.023 | 0.839 ± 0.02 | 0.881 ± 0.02 | 0.899 ± 0.02 | 0.906 ± 0.05 | 0.93 ± 0.02 | 0.923 ± 0.03 | – | |
# Features | 32 | 22 | 23 | 33 | 75 | 23 | 50 | 79 |