Table 4 Putative and validated targets for each of the more likely regulating miRNAs
More likely regulating miRNAs | Computationally predicted targets | Biologically validated targets |
|---|---|---|
hsa-miR-142-3p | • ASH1L [ash1 (absent, small, or homeotic)-like (Drosophila)] • CP [ceruloplasmin (ferroxidase)] • MLLT1 [myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1] • MLLT4 [myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4] • SAG [S-antigen; retina and pineal gland (arrestin)] | • CCNT2 [cyclin T2] • EGR2 [early growth response 2] • HOXA10 [homeobox A10] • HOXA7 [homeobox A7] |
hsa-miR-17-5p | • AGO2 [argonaute 2, RISC catalytic component] • BCR [breakpoint cluster region] • NPM1 [nucleophosmin (nucleolar phosphoprotein B23, nunatrin)] | • E2F1 [E2F transcription factor 1] • RUNX1 [runt related transcription factor 1] • TP53 [tumor protein p53] |
hsa-miR-18a-3p | • ARHGAP26 [Rho GTPase activating protein 26] • IMPACT [impact RWD domain protein] | None |
hsa-miR-128-3p | • PHF6 [PHD finger protein 6] | None |
hsa-miR-193a-3p | None | • MCL1 [myeloid cell leukemia 1] |