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Table 4 Putative and validated targets for each of the more likely regulating miRNAs

From: A semantics-oriented computational approach to investigate microRNA regulation on glucocorticoid resistance in pediatric acute lymphoblastic leukemia

More likely regulating miRNAs Computationally predicted targets Biologically validated targets
hsa-miR-142-3p • ASH1L [ash1 (absent, small, or homeotic)-like (Drosophila)]
• CP [ceruloplasmin (ferroxidase)]
• MLLT1 [myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1]
• MLLT4 [myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4]
• SAG [S-antigen; retina and pineal gland (arrestin)]
• CCNT2 [cyclin T2]
• EGR2 [early growth response 2]
• HOXA10 [homeobox A10]
• HOXA7 [homeobox A7]
hsa-miR-17-5p • AGO2 [argonaute 2, RISC catalytic component]
• BCR [breakpoint cluster region]
• NPM1 [nucleophosmin (nucleolar phosphoprotein B23, nunatrin)]
• E2F1 [E2F transcription factor 1]
• RUNX1 [runt related transcription factor 1]
• TP53 [tumor protein p53]
hsa-miR-18a-3p • ARHGAP26 [Rho GTPase activating protein 26]
• IMPACT [impact RWD domain protein]
hsa-miR-128-3p • PHF6 [PHD finger protein 6] None
hsa-miR-193a-3p None • MCL1 [myeloid cell leukemia 1]