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Table 5 The top 20 candidate targets of rhizome coptidis and turmeric under the HalfTarget

From: Heterogeneous network propagation for herb target identification

Rhizoma coptidis Turmeric
Rank Candidate Target Score Rank Candidate Target Score
1 PTGS2 0.0311 1 CASP3 0.0657
2 NOS2 0.0285 2 TNF 0.0619
3 BAX 0.0259 3 BCL2 0.0518
4 CASP9 0.0252 4 JUN 0.0438
5 CDKN1A 0.0238 5 VEGFA 0.0424
6 NFKBIA 0.0220 6 BAX 0.0400
7 FOS 0.0212 7 IL6 0.0390
8 CDK2 0.0203 8 MMP9 0.0355
9 VEGFA 0.0202 9 CASP9 0.0334
10 IL4 0.0178 10 AKT1 0.0326
11 BCL2L1 0.0160 11 CCND1 0.0302
12 AKT1 0.0146 12 CDK2 0.0296
13 HERC5 0.0143 13 MAPK1 0.0282
14 CDC2 0.0135 14 CDK4 0.0269
15 EIF6 0.0132 15 XDH 0.0245
16 MMP9 0.0130 16 SOD1 0.0241
17 IL2 0.0126 17 PRKCB 0.0233
18 MPO 0.0121 18 CYP3A4 0.0213
19 EGFR 0.0120 19 VCAM1 0.0211
20 HIF1A 0.0118 20 MYC 0.0202
  1. The bold candidate targets are known targets of given herbs