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Table 4 The top 20 candidate targets of rhizome coptidis and turmeric under the NoTarget

From: Heterogeneous network propagation for herb target identification

Rhizoma coptidis Turmeric
Rank Candidate Target Score Rank Candidate Target Score
1 CASP3 0.4526 1 CASP3 0.2750
2 RELA 0.4109 2 RELA 0.2554
3 PTGS2 0.3834 3 PTGS2 0.2222
4 TNF 0.2988 4 TNF 0.1816
5 NOS2 0.2771 5 BCL2 0.1716
6 BCL2 0.2708 6 NOS2 0.1624
7 CYP3A4 0.2325 7 BAX 0.1403
8 SOD1 0.2132 8 TP53 0.1349
9 BAX 0.2096 9 JUN 0.1318
10 CASP9 0.1928 10 CYP3A4 0.1230
11 IL6 0.1846 11 SOD1 0.1182
12 JUN 0.1777 12 FOS 0.1165
13 CDKN1A 0.1701 13 CASP9 0.1158
14 TP53 0.1701 14 VEGFA 0.1141
15 IL1B 0.1658 15 IL6 0.1111
16 VEGFA 0.1612 16 CDKN1A 0.1106
17 FOS 0.1561 17 NFKBIA 0.0992
18 ICAM1 0.1558 18 IL1B 0.0926
19 HMOX1 0.1502 19 MMP9 0.0873
20 MAPK1 0.1358 20 ICAM1 0.0872
  1. The bold candidate targets are known targets of given herbs