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Table 4 Thirty Drugs most highly associated with hypertension by naïve tabulation, sorted by p-value and, in the case of ties, by odds ratio

From: Monitoring prescribing patterns using regression and electronic health records

Drug name Unadjusted OR p-value In MEDI?
Hydrochlorothiazide 43.1 0 T
Amlodipine 31.4 0 T
Lisinopril 29.8 0 T
Losartan 23.9 0 T
Atenolol 21.1 0 T
Valsartan 19.9 0 T
Metoprolol 14.8 0 T
Hepatitis b antigen peptide 13.0 0 F
Glipizide 12.6 0 F
Carvedilol 12.4 0 T
Simvastatin 9.90 0 F
Atorvastatin 9.76 0 T
Aspirin 9.64 0 F
Metformin 8.30 0 F
Furosemide 7.69 0 T
Insulin 7.09 0 F
Omeprazole 3.62 0 F
Multi vitamin 2.91 0 F
Chlorthalidone 69.7 2.83e-319 T
Clopidogrel 10.6 4.29e-317 F
Calcium 3.20 5.62e-298 F
Glucose 3.31 8.85e-271 F
Esomeprazole 3.23 1.88e-262 F
Rosuvastatin 7.94 2.12e-254 F
Nifedipine 17.0 9.32e-251 T
Ergocalciferol 3.23 1.32e-246 F
Alendronate 6.57 1.46e-246 F
Warfarin 4.25 1.9e-222 F
Enalapril 10.8 2.79e-222 T
Docusate 2.88 9.2e-214 F
  1. The unadjusted OR is the estimated odds ratio for use of the drug comparing those with and without hypertension. The p-value comes from Fisher’s exact test