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Table 4 Thirty Drugs most highly associated with hypertension by naïve tabulation, sorted by p-value and, in the case of ties, by odds ratio

From: Monitoring prescribing patterns using regression and electronic health records

Drug name

Unadjusted OR

p-value

In MEDI?

Hydrochlorothiazide

43.1

0

T

Amlodipine

31.4

0

T

Lisinopril

29.8

0

T

Losartan

23.9

0

T

Atenolol

21.1

0

T

Valsartan

19.9

0

T

Metoprolol

14.8

0

T

Hepatitis b antigen peptide

13.0

0

F

Glipizide

12.6

0

F

Carvedilol

12.4

0

T

Simvastatin

9.90

0

F

Atorvastatin

9.76

0

T

Aspirin

9.64

0

F

Metformin

8.30

0

F

Furosemide

7.69

0

T

Insulin

7.09

0

F

Omeprazole

3.62

0

F

Multi vitamin

2.91

0

F

Chlorthalidone

69.7

2.83e-319

T

Clopidogrel

10.6

4.29e-317

F

Calcium

3.20

5.62e-298

F

Glucose

3.31

8.85e-271

F

Esomeprazole

3.23

1.88e-262

F

Rosuvastatin

7.94

2.12e-254

F

Nifedipine

17.0

9.32e-251

T

Ergocalciferol

3.23

1.32e-246

F

Alendronate

6.57

1.46e-246

F

Warfarin

4.25

1.9e-222

F

Enalapril

10.8

2.79e-222

T

Docusate

2.88

9.2e-214

F

  1. The unadjusted OR is the estimated odds ratio for use of the drug comparing those with and without hypertension. The p-value comes from Fisher’s exact test